The Bjorkman Lab at Caltech


Fire Updates and Recovery Resources COVID-19 information and policies at Caltech BJÖRKPeople BJÖRKLab Information BJÖRKTeaching BJ Ö RKPublications BJÖRKStructures BJÖRKCommunity Development BJÖRK Protocols Paper Guidelines HIV Language Guide Plasmid requests (Addgene) Lab mAbs & other reagents Safety \| Lab stuff Instrument sign-up calendar Bjorklab ordering STRUCTURAL BIOLOGY RELATED GROUPS Chen Lab \| Clemons Lab Hoelz Lab \| Mayo Lab Rees Lab \| Voorhees Lab Protein Expression Center Molecular Observatory Cryo-EM Facility SSRL beamtime/Crystal trays WEBSITES OF INTEREST Caltech Biological Imaging Center Rosen Bioengineering Center External fellowships for grad student Fellowships Resources for postdocs Integrated structural biology platforms History of Crystallography WebofScience \| CITLibrary \| PubMed CITdirectory \| CITaccess \| BBE Seminars CRYSTALLOGRAPHY RESOURCES California Institute of Technology Division of Biology and Biological Engineering MC 114-96 \| 1200 E. California Blvd., Pasadena, CA 91125 (626) 395-8351 phone murphym [at] caltech dot edu	Our laboratory is interested in immune recognition of viral pathogens. We are investigating the immune responses against HIV-1 and other viruses, most recently SARS-CoV-2, in order to develop improved therapeutics and/or vaccines. We use X-ray crystallography, electron microscopy, and biochemistry to study pathogen glycoproteins and host immune proteins. Using structural information and alternate antibody architectures, we are engineering antibody-based reagents with increased potency and breadth. We are also investigating the structural correlates of potent antibody-mediated neutralization of HIV-1, SARS-CoV-2, and hepatitis C virus to better understand what leads to naturally-occurring potent neutralizing antibodies. Anthony West has developed Variant Database, a SARS-CoV-2 mutation pattern query tool, 06/2021 HIVRADP01 2024 Project: Developing Immunogens to Elicit Broadly Neutralizing anti-HIV-1Antibodies -Animation, Visualizing HIV-1: Andy DeLaitsch, 2025 -Wolf Prize: Pamela Bjorkman, 2025 -Pearl Meister Greengard Prize: Pamela Bjorkman, 2021 - Webinar: Pamela Bjorkman: Viruses, Antiviral and Vaccines, 04/2020 -The HIV Life Cycle -Donate in memory of Will Lange, 2016 –Watson Lecture, Pamela Bjorkman, 2015 –TEDxCaltech: New Anti-HIV Agents, 2013 –Traveling with Purpose - Volunteering in India, 2012 –World AIDS Day - News Conf on KNBC-TV, 2012 –LA Theatre Works: Rosalind Franklin, 2011 –Magnus Hoffmann wins Clauser Doctoral Prize, 2022 –Rachel Galimidi wins Clauser Doctoral Prize, 2016 –Gwen Owens, Crystals in space, 2013