PUBLICATIONS:
Ma, D., Herndon,, N., Quynh Le, J., Abruzzi, K.C., Zinn, K., and Rosbash, M. (2023)
Neural connectivity molecules best identify the heterogeneous clock and dopaminergic cell types in the Drosophila adult brain.
Science Advances 9, eade8500.
Lee, H-K., Anaya, M., Ladinsky, M.S., Reitsma, J. M., and Zinn, K. (2023)
An extracellular vesicle targeting ligand that binds to Arc proteins and facilitates Arc transport in vivo.
eLife, https://doi.org/10.7554/eLife.82874
Siepe, D.H., Henneberg, L.T., Wilson, S.C., Hess, G.T., Bassik, M.C., Zinn, K., and Garcia, K.C. (2022)
Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform.
eLife 11: e81398 DOI: https://doi.org/10.7554/eLife.81398
Xu, S., Sergeeva, A. P., Katsamba, P.S., Mannepalli, S., Bahna, F., Bimela, J., Zipursky, S.L., Shapiro, L., Honig, B., and Zinn, K. (2022)
Affinity requirements for control of synaptic targeting and neuronal cell survival by heterophilic IgSF cell adhesion molecules.
Cell Reports 39, 110618; https://doi.org/10.1016/j.celrep.2022
Bali, N., Lee, H-K., and Zinn, K. (2022)
Sticks and Stones, a conserved cell surface ligand for the Type IIa RPTP Lar, regulates neural circuit wiring in Drosophila.
eLife 11:e71469 DOI: 10.7554/eLife.71469
Brovero, S.G., Fortier, J.C., Hu, H., Lovejoy, P.C., Newell, N.R., Palmateer, C.M., Tzeng, R-Y., Lee, P-T., Zinn, K., and Arbeitman, M.N. (2021)
Investigation of Drosophila fruitless neurons that express Dpr/DIP cell adhesion molecules.
eLife 10:e6301. doi: 10.7554/eLife.63101
Wojtowicz, W.M., Vielmetter, J., Fernandes, R.A. Siepe, D.H., Eastman, C.L., Chisholm, G.B., Cox, S., Klock, H., Anderson, P.W.,
Rue, S.M., Miller, J.J., Glaser, S.M., Bragstad, M.L., Vance, J., Lam, A.W., Lesley, S.,A., Zinn, K., and Garcia, K.C. (2020)
A Human IgSF Interactome Network Reveals a Complex Network of Protein-Protein Interactions.
Cell 182, 1027-1043
Bali, N., and Zinn, K. (2019)
Visualization of binding patterns for five leucine-rich repeat proteins in the Drosophila embryo.
microPublication Biology. 10.17912/micropub.biology.000199
Menon, K.P., Kulkarni, V., Takemura, S-Y., Anaya, M., and Zinn, K. (2019)
Interactions between Dpr11 and DIP-γ control selection of amacrine neurons in Drosophila color vision circuits.
eLife 8:e48935. DOI: https://doi.org/10.7554/eLife.48935
Bali, N., and Zinn, K (2019)
Visualization of binding patterns for five Leucine-rich repeat proteins in the Drosophila embryo.
microPublication Biology
Bali, N., Lee, H., and Zinn, K (2019)
Identification of four Drosophila Toll-related proteins as ligands for the PTP69D receptor tyrosine phosphatase.
microPublication Biology. 10.17912/micropub.biology.000159
Tsarouhas, V., Liu, D., Tsikala, G., Fedoseienko, A., Zinn, K., Matsuda, R., Billadeau, D.D., and Samakovlis, C. (2019).
WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis.
Nature Communications 10, DOI: 10.1038/s41467-019-10229-6.
Cheng, C., Park, Y., Kurleto, J.D., Jeon, M., Zinn, K., Thornton, J.W., and Özkan, E. (2019)
A new family of neural wiring receptors across bilaterians defined by phylogenetic, biochemical and structural evidence.
Proc. Natl. Acad. Sci., 116 (20) 9837-9842. DOI: 10.1073/pnas.1818631116
Ashley, J. Sorrentino, V., Nagarkar-Jaiswal, S., Tan, L., Xu, S., Xiao, Q., Zinn, K., and Carrillo, R.A. (2019)
Transsynaptic interactions between IgSF proteins DIP-α and Dpr10 are required for motor neuron targeting specificity in Drosophila.
eLife 8:e42690, DOI: 10.7554/eLife.42690
Al-Anzi, B., and Zinn, K. (2018)
Identification and characterization of mushroom body neurons that regulate fat storage in Drosophila.
Neural Development 13, DOI: 10.1186/s13064-018-0116-7.
Hanqing Li, Ash Watson, Agnieszka Olechwier, Michael Anaya, Siamak K Sorooshyari, Dermott P Harnett, Hyung-Kook (Peter) Lee,
Jost Vielmetter, Mario A Fares, K Christopher Garcia, Engin Özkan, Juan-Pablo Labrador, Kai Zinn (2017)
Deconstruction of the Beaten Path-Sidestep interaction network provides insights into neuromuscular system development.
eLife 2017;6:e28111
Zinn, K., and Özkan, E. (2017)
Neural immunoglobulin superfamily interaction networks.
Current Opinion in Neurobiology 45, 99-105 (Review).
Al-Anzi, B., Gerges, S., Olsman, N., Ormerod, C., Piliouras, G., Ormerod, J., and Zinn, K. (2017)
Modeling and analysis of modular structure in diverse biological networks.
Journal of Theoretical Biology 422, 18-30.
Zinn, K. (2016) Building a ladder to Hershey Heaven.
eLife, pii: e15591. doi:10.7554/
eLife.15591. (Review)
Bali, N., Lee, H-K., and Zinn, K. (2016)
Live staining of Drosophila embryos to detect and characterize expression of cell-surface RPTP ligands. In Methods in Molecular Biology, vol. 1447, Rafael Pulido (Eds.):
Protein Tyrosine Phosphatases, 978-1-4939- 3744-8, Springer.
Carrillo, R.A., Özkan, E., Menon, K.P., Nagarkar-Jaiswal, S., Lee, P-T., Jeon, M., Birnbaum, M.E., Bellen, H.J., Garcia, K.C., and Zinn, K. (2015)
Control of synaptic connectivity by a network of Drosophila IgSF cell surface proteins.
Cell 163, 1770-1782.
Tan, L., Zhang, K.X., Pecot, M.Y., Nagarkar-Jaiswal, S., Lee, P-T., Takemura, S., McEwen, J.M., Nern, A., Xu, S., Tadros, W., Chen, Z., Zinn, K.,
Bellen, H.J., Morey, M., and Zipursky, S.L. (2015)
Ig superfamily ligand and receptor pairs expressed in synaptic partners in Drosophila.
Cell 163, 1756-1769.
Menon, K.P., Carrillo, R.A., and Zinn, K. (2015)
The translational regulator Cup controls NMJ presynaptic terminal morphology.
Molecular and Cellular Neuroscience 67, 126-136.
Al-Anzi, B., Arpp. P. Gerges, S., Ormerod, C, Olsman, N., and Zinn, K. (2015)
Experimental and computational analysis of a large protein network that controls fat storage reveals the design principles of a signaling network.
PLoS Computational Biology, e1004264.
Jeon, M., and Zinn, K. (2015)
R3 receptor tyrosine phosphatases: conserved regulators of receptor tyrosine kinase signaling and tubular organ development.
Seminars in Cell and Developmental Biology 37, 119-126 (Review).
Bower, D.V., Jesudason, E. C., Lee, H-K., Lansford, R., Zinn, K., and Fraser, S.E. (2014)
Airway branching has conserved needs for local innervation but not neurotransmission.
BMC Biology 12, article #92.
Ozkan, E., Carrillo, R.A., Eastman, C.L., Weiszmann, R., Waghray, D., Johnson, K.G., Zinn, K., Celniker, S.E., and Garcia, K.C. (2013)
An extracellular interactome of cell surface Immunoglobulin and Leucine-rich repeat proteins reveals novel receptor-ligand networks.
Cell 154, 228-239.
Lee, H-K., Cording, A., Vielmetter, J., and Zinn, K. (2013)
Interactions between a receptor tyrosine phosphatase and a cell surface ligand regulate axon guidance and glial-neuronal communication.
Neuron 78, 813-826.
Carrillo, R.A., Menon, K., and Zinn, K. (2013)
Is instability good for the brain?
Neuron, 77, 599-600 (Review).
Menon, K.P., Carrillo, R.A., and Zinn, K. (2013)
Development and plasticity of the Drosophila larval neuromuscular junction.
WIREs Developmental Biology, doi: 10.1002/wdev.108 (Review).
Kurusu, M., Katsuki, T., Zinn, K., and Suzuki, E. (2012)
Developmental changes in expression, subcellular distribution, and function of Drosophila N-cadherin are guided by cell-intrinsic programs during neuronal differentiation.
Developmental Biology 366, 204-217.
Jeon, M., Scott, M.P., and Zinn, K. (2012)
Interactions between Type III receptor tyrosine phosphatases and growth factor receptor tyrosine kinases regulate tracheal tube formation in Drosophila.
Biology Open 1, 548-558.
Al-Anzi, B., and Zinn, K. (2011)
Genetics of fat storage in flies and worms: What went wrong? (Review)
Frontiers in Genetics 2, 87.
Sztul, T., Burgess, J., Jeon, M., Zinn, K., Marques, G., Brill, J., and Sztul, E. (2011)
The Garz Sec7 domain guanine nucleotide exchange factor for ARF regulates salivary gland development in Drosophila.
Cellular Logistics 1, 69-76.
Wright, A.P., Fox, A.N., Johnson, K.G., and Zinn, K. (2010)
Systematic screening of Drosophila deficiency mutations for embryonic phenotypes and orphan receptor ligands.
PLoS ONE 5(8):e12288.
Al-Anzi, B., Armand, E., Nagamei, P., Olszewski, M., Sapin, V., Waters, C., Zinn, K., Wyman, R.J., and Benzer, S. (2010)
The leucokinin pathway and its neurons regulate meal size in fruit flies.
Current Biology 20, 969-978.
Al-Anzi, B., and Zinn, K. (2010)
Colorimetric measurement of triglycerides cannot provide an accurate measure of stored fat content in Drosophila.
PLoS ONE 5(8):e12353.
Salazar, A.M., Silverman, E.J., Menon, K.P, and Zinn, K. (2010)
Regulation of synaptic Pumilio function by an aggregation-prone domain.
Journal of Neuroscience30, 515-522.
Lee, H-K., Wright, A.P., and Zinn, K. (2009)
Live dissection of Drosophila embryos: streamlined methods for screening mutant collections by antibody staining.
Journal of Visualized Experiments 29;(34), pii: 1647. doi: 10.3791/1647.
Hong, W., Zhu, H., Potter, C.J., Barsh, G., Kurusu, M., Zinn, K., and Luo, L. (2009)
Leucine-rich repeat transmembrane protein Capricious instructs discrete dendritic targeting in an olfactory map.
Nature Neuroscience, 12, 1542-1550.
Wright, A.P., and Zinn, K. (2009)
Guidance receptors find their places in the axonal order (Review).
Neuron 64, 150-152.
Al-Anzi, B., Sapin, V., Waters, C., Zinn, K., Wyman, R.J., and Benzer, S. (2009)
Obesity-blocking neurons in Drosophila.
Neuron 63, 329-341.
Jeon, M., and Zinn, K. (2009).
Receptor tyrosine phosphatases control tracheal tube geometries through negative regulation of Egfr signaling.
Development 136, 3121-3129.
Zinn, K. (2009)
Choosing the road less traveled by: a ligand-receptor system that controls target recognition by Drosophila motor axons. (Review).
Genes and Development23, 1042-1045.
Bugga, L, Ratnaparkhi, A., and Zinn, K. (2009).
The cell surface receptor Tartan is a potential in vivo substrate for the receptor tyrosine phosphatase Ptp52F.
Molecular and Cellular Biology 29, 3390-3400.
Menon, K.P., Andrews, S., Murthy, M., Gavis, E.R., and Zinn, K. (2009).
The translational repressors Nanos and Pumilio have divergent effects on presynaptic terminal growth and postsynaptic glutamate receptor composition.
Journal of Neuroscience 29, 5558-5572.
Kurusu, M., Cording, A., Taniguchi, M., Menon, K.P., Suzuki, E., and Zinn, K. (2008)
A screen of cell-surface molecules identifies leucine-rich repeat proteins as key mediators of synaptic target selection in the Drosophila neuromuscular system.
Neuron59, 972-985.(plus an online supplement)
Jeon, M., Nguyen, H., Bahri, S., and Zinn, K. (2008).
Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily.
Neural Development 3, 3.
Kurusu, M., and Zinn, K. (2008)
Receptor tyrosine phosphatases regulate birth order-dependent axonal fasciculation and midline repulsion during development of the Drosophila mushroom body.
Molecular and Cellular Neuroscience 38, 5 3-65.
Ratnaparkhi,
A., and Zinn, K. (2007)
The secreted cell signal Folded
Gastrulation regulates glial morphogenesis and axon guidance
in Drosophila.
Developmental
Biology 308, 158–168
Fox,
A.N., and Zinn, K. (2005)
The transmembrane heparan sulfate
proteoglycan Syndecan is an in
vivo ligand for the DLAR receptor tyrosine
phosphatase.
Current
Biology 15, 1701-1711. (plus an online supplement).
Sherwood,
N.T., Sun, Q., Xue, M., Zhang, B., and Zinn, K. (2004)
Drosophila Spastin regulates synaptic microtubule networks and is
required for normal motor function.
PLOS
Biology 2, 2094-2111.
42. Menon,
K., Sanyal, S. Habara, Y., Sanchez, R., Wharton, R.P.,
Ramaswami, M., and Zinn, K. (2004)
The translational repressor
Pumilio regulates presynaptic morphology and controls
postsynaptic accumulation of translation factor eIF-4E.
Neuron 44, 663-676.
Zinn,
K. (2004)
Dendritic tiling: new insights from genetics.
Neuron 44, 211-213.
Kraut,
R., and Zinn, K. (2004)
Roundabout 2 regulates migration
of sensory neurons by signaling in trans.
Current
Biology 14, 319-329.
Cepko,
C.L., and Zinn, K. (2002)
Development: an editorial overview.
Current
Opinion in Neurobiology 12, 11-13.
Schmid,
A., Schindelholz, B., and Zinn, K. (2002)
Combinatorial
RNAi: a method for evaluating the functions of gene families
in Drosophila.
Trends
in Neuroscience 25, 71-74.
Dubuque,
S.H., Schachtner, J., Nighorn, A.J., Menon, K., Zinn,
K., and Tolbert, L.P. (2001)
Immunolocalization of synaptotagmin
for the study of synapses in the developing antennal lobe
of Manduca sexta. J. Comp.
Neurol. 441, 277-287.
Schindelholz,
B., Knirr, M., Warrior, R., and Zinn, K. (2001)
Regulation
of CNS and motor axon guidance in Drosophila by the receptor tyrosine phosphatase DPTP52F.
Development 128, 4371-4382.
Kraut,
R., Menon, K., and Zinn, K. (2001)
A gain-of-function
screen for genes controlling motor axon guidance and synaptogenesis
in Drosophila.
Current
Biology 11, 417-430. (plus an online supplement,
pp. S1-S24).
Sun,
Q., Schindelholz, B., Knirr, M., Schmid, A., and Zinn,
K. (2001)
Complex genetic interactions among four receptor
tyrosine phosphatases regulate axon guidance in Drosophila.
Molectular
and Cellular Neuroscience17, 274-291.
Sun,
Q., Bahri, S., Schmid, A., Chia, W., and Zinn, K. (2000)
Receptor tyrosine phosphatases regulate axon guidance
across the midline of the Drosophila embryo.
Development 127, 801-812.
Zinn,
K., and Schmid, A. (1999).
Derailed axons get on track.
(Review)
Nature 402, 475-476.
Garrity,
P.A., Lee, C-H., Salecker, I., Robertson, H., Desai, C.J.,
Zinn, K., and Zipursky, S.L. (1999)
The Drosophila receptor
protein tyrosine phosphatase DPTP69D is required for target
selection by retinal axons.
Neuron 22, 707-717.
Zinn,
K., and Sun, Q. (1999)
Slit branches out: a secreted protein
mediates both attractive and repulsive axon guidance (Review).
Cell 97, 1-4.
Desai,
C.J., Garrity, P.A., Keshishian, H., Zipursky, S.L., and
Zinn, K. (1999)
The Drosophila SH2-SH3 adapter protein
Dock is expressed in embryonic axons and facilitates synapse
formation by the RP3 motoneuron.
Development 126, 1527-1535.
Wills,
Z., Marr, L., Zinn, K., Goodman, C.S., and Van Vactor,
D. (1999)
Profilin and the Abl tyrosine kinase are required
for motor axon outgrowth in the Drosophila embryo.
Neuron 22, 291-299.
Zinn,
K. (1998)
Receptor tyrosine phosphatases: the worm clears
the picture (Review).
Current
Biology 8, 725-726.
Menon,
K.P., and Zinn, K. (1998).
Tyrosine kinase inhibition
produces specific alterations in axon guidance in the
grasshopper embryo.
Development 125, 4121-4131.
Gindhart,
J.G., Desai, C.J., Beushausen, S., Zinn, K., and Goldstein,
L.S.B. (1998)
Kinesin light chains are essential for axonal
transport in Drosophila. J.
Cell Biol. 141, 443-454.
Fashena,
S.J., and Zinn, K. (1997)
The transmembrane glycoprotein
gp150 is a substrate for the receptor tyrosine phosphatase
DPTP10D in Drosophila cells. Mol.
Cell. Biol. 17, 6859-6867.
Zhang,
Y., Chou, J.H., Bradley, J., Bargmann, C.I., and Zinn,
K. (1997)
The C. elegans 7-transmembrane protein ODR-10
functions as an odorant receptor in mammalian cells.
Proc.
Natl. Acad. Sci. USA 94, 12162-12167.
Condron,
B.G., and Zinn, K. (1997)
Regulated neurite tension as
a mechanism for determination of neuronal arbor geometries
in vivo.
Current
Biology 7, 813-816.
Desai,
C.J., Krueger, N.X., Saito, H., and Zinn, K. (1997)
Competition
and cooperation among receptor tyrosine phosphatases control
motoneuron growth cone guidance in Drosophila.
Development 124, 1941-1952.
Bradley,
J., Zhang, Y., Bakin, R., Lester, H.A., Ronnett, G.V.,
and Zinn, K. (1997)
Functional expression of the heteromeric
"olfactory" cyclic nucletotide-gated channel in the hippocampus:
a potential effector of synaptic plasticity in brain neurons.
J.
Neurosci. 17, 1993-2005.
Desai,
C.J., Sun, Q., and Zinn, K. (1997)
Tyrosine phosphorylation
and axon guidance: of flies and mice (Review).
Current
Opinion in Neurobiology 7, 70-74.
Desai,
C.J., Gindhart, J.G., Goldstein, L.S.B., and Zinn, K.
(1996)
Receptor tyrosine phosphatases are required for
motor axon guidance in the Drosophila embryo.
Cell 84, 599-609.
Tongiorgi,
E., Bernhardt, R.R., Zinn, K., and Schachner, M. (1995)
Tenascin-C messenger RNA is expressed in cranial neural
crest cells, in some placodal derivatives, and in discrete
domains of the embryonic zebrafish brain. J.
Neurobiol. 28, 391-407.
Fashena,
S.J., and Zinn, K. (1995)
The ins and outs of receptor
tyrosine phosphatases (Review).
Current
Biology 5, 1367-1369.
Condron,
B.G., and Zinn, K. (1995)
Activation of cAMP-dependent
protein kinase triggers a glial-to-neuronal cell fate
switch in an insect neuroblast lineage.
Current
Biology 5, 51-61.
Hamilton,
B.A., Ho, A., and Zinn, K. (1995)
Targeted mutagenesis
and genetic analysis of a Drosophila receptor-linked
protein tyrosine phosphatase gene.
Roux's Arch. Dev. Biol.
204, 187-192.
Desai,
C.J., Popova, E., and Zinn, K. (1994)
A Drosophila receptor tyrosine phosphatase expressed in the embryonic
CNS and larval optic lobes is a member of the set of proteins
bearing the 'HRP' carbohydrate epitope. J.
Neurosci. 14, 7272-7283.
Tian,
S-S., and Zinn, K. (1994)
An adhesion molecule-like protein
that interacts with and is a substrate for a Drosophila receptor-linked protein tyrosine phosphatase. J.
Biol. Chem.269, 28478-28486.
Condron,
B.G., and Zinn, K. (1994)
The grasshopper median neuroblast
is a multipotent progenitor cell that generates glia and
neurons in distinct temporal phases. J.
Neurosci. 14, 5766-5777.
Condron,
B.G., Patel, N.H., and Zinn, K. (1994)
engrailed controls
glial/neuronal cell fate decisions at the midline of the
central nervous system.
Neuron 13, 541-554.
Bradley,
J., Li, J., Davidson, N., Lester, H.A., and Zinn, K. (1994)
Heteromeric olfactory cyclic nucleotide-gated channels:
a subunit that confers increased sensitivity to cAMP.
Proc. Natl. Acad. Sci. USA 91, 8890-8894.
Patel,
N.H., Condron, B.G., and Zinn, K. (1994)
Pair-rule expression
patterns of even-skipped are found in both short and long
germ beetles.
Nature 367, 429-434.
Hamilton,
B.A., and Zinn, K. (1994)
From clone to mutant gene. in:
Drosophila melanogaster: practical uses in cell and molecular
biology. Edited by L.S.B. Goldstein and E.A. Fyrberg;
Academic Press, Orlando, FL; pp. 81-94.
Zinn,
K., and Condron, B.G. (1994)
Cell fate decisions in the
grasshopper central nervous system (Review).
Current Opinion
in Cell Biology 6, 783-787.
Uezono,
Y., Bradley, J., Min, C., McCarty, N., Quick, M., Riordan,
J.R., Chavkin, C., Zinn, K., Lester, H.A., and Davidson,
N. (1993)
Receptors that couple to two classes of G proteins
increase cAMP and activate CFTR expressed in Xenopus oocytes.
Receptors and Channels 1, 233-241.
Wang,
W-C., Zinn, K., and Bjorkman, P.J. (1993)
Expression and
structural studies of fasciclin I, an insect cell adhesion
molecule. J.
Biol. Chem. 268, 1448-1455.
McAllister,
L., Rehm, E.J., Goodman, C.S., and Zinn, K. (1992)
Alternative
splicing of micro-exons creates multiple forms of the
insect cell adhesion molecule fasciclin I. J.
Neurosci. 12, 895-905.
McAllister,
L., Goodman, C.S., and Zinn, K. (1992)
Dynamic expression
of the cell adhesion molecule fasciclin I during embryonic
development in
Drosophila. Development 115, 267-276.
Tian,
S-S., Tsoulfas, P., and Zinn, K. (1991)
Three receptor-linked
protein-tyrosine phosphatases are selectively expressed
on central nervous system axons in the Drosophila embryo.
Cell 67, 675-685. |