We request that you acknowledge both the PEC and the Beckman Institute in your publications by entering a sentence like this in the Acknowledgements section of your paper: "We thank Dr. Jost Vielmetter, ..., and ... at the Caltech Protein Expression Center in the Beckman Institute for x-y-z services."
The following papers acknowledge the PEC.
2026
Cohen, AA, Keeffe, JR, Manasyan, L, Madireddy, I, Priso Fils, A-CI, Dam, K-MA, Stober, HE, Hills, RA, Moon, WJ, Lin, PJC, Howarth, MR, Hoffmann, MAG, Bjorkman, PJ (2026) mRNA delivery of mosaic-8 pan-sarbecovirus RBD vaccines elicits distinct antibody epitope signatures. bioRxiv 2025.10.21.683747. doi:10.1101/2025.10.21.683747
2025
Anaya MA, Wang ML, Gonzalez E, Lam AW, Vasnarungruengkul P, Vielmetter J, Wojtowicz WM, Zinn K (2025) A multiplex extracellular interactome screening method employing high-avidity nanoparticles. bioRxiv [Preprint]. Jul 14:2025.07.09.663943. doi:10.1101/2025.07.09.663943. PMCID: PMC12338595 Free PMC article.
Brott BK, Raissi AJ, Micheva KD, Vielmetter J, Mendes MS, Baccus CJ, Huang J, Shatz, CJ (2025) C4d, a high-affinity LilrB2 ligand, is elevated in Alzheimer's disease and mediates synapse pruning. Proc Natl Acad Sci U S A. 2025 Sep 23;122(38):e2519253122. doi:10.1073/pnas.2519253122. Epub 2025 Sep 18.PMID: 40966293
Catanzaro, NJ*, Wu, Z*, Fan, C, Jefferson, V, Abdelgadir, A, Schäfer, A, Yount, BL, Bjorkman, PJ, Baric, R, Letko, M (2025) ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses. Nat Commun 16 4932. PMCID: PMC12119886 doi:10.1038/s41467-025-60286-3 *Equal contributions.
This paper was discussed on TWiV https://podcasts.apple.com/us/podcast/this-week-in-virology/id300973784?i=1000710720688
Cohen, AA, Keeffe, JR, Rorick, AV, Rho, S, Priso Fils, A-CI, Manasyan, L, Gao, H, Gnanapragasam, PNP, Funke, HH, Randolph, TW, Garcea, RL, Bjorkman, PJ (2025) Broad anti-sarbecovirus responses elicited by a single administration of mosaic-8 RBD-nanoparticle vaccine prepared using atomic layer deposition. iScience, 113649. doi:10.1016/j.isci.2025.113649
Dam, K-MA, Gristick, HB, Li, YE, Yang, Z, Gnanapragasam, PNP, West AP Jr, Seaman, MS, Bjorkman, PJ (2025) Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design. Cell Reports. 44: 115713. PMCID: PMC12117015 doi:10.1016/j.celrep.2025.115713.
Fan, C, Cohen, AA, Dam, K-MA, Rorick, AV, Priso Fils, A-CI, Yang, Z, Gnanapragasam, PNP, Segovia, LN, Huey-Tubman, KE, Moon, WJ, Lin, PJC, Bjorkman, PJ, Hoffmann, MAG (2025) Bivalent mRNA booster encoding virus-like particles elicits potent polyclass RBD antibodies in pre-vaccinated mice. eLife 14:RP108959. doi:10.7554/eLife.108959.1
Fan, C*, Keeffe, JR*, Malecek, KE, Cohen, AA, West, AP, Baharani, BA , Rorick, AV, Gao, H, Gnanapragasam, PNP, Rho, S, Alvarez, J, Segovia, LN, Hatziioannou, T, Bieniasz, PD, Bjorkman, PJ (2025) Cross-reactive sarbecovirus antibodies induced by mosaic RBD-nanoparticles. Proc. Natl. Acad. Sci. U.S.A. 122 (21) e2501637122. PMCID: PMC12130868 doi:10.1073/pnas.2501637122 *Equal contributions.
Gieselmann, L*, DeLaitsch, AT*, Rohde, M, Gruell, H, Kreer, C, Ercanoglu, MS, Gristick, HB, Schommers, P, Ahmadov, E, Radford, C, Mazzolini, A, Zhang, L, West, AP Jr, Worczinski, J, Momot, A, Reichwein, ML, Knüfer, J, Stumpf, R, Mkhize, NN, Kaldine, H, Bhebhe, S, Deshpande, S, Giovannoni, F, Stefanutti, E, Benigni, F, Havenar-Daughton, C, Corti, D, Kroidl, A, Adhikari, A, Nanfack, AJ, Ambada, GE, Duerr, R, Maganga, L, William, W, Ntinginya, NE, Wolf, T, Geldmacher, C, Hoelscher, M, Lehmann, C, Moore, PL, Mora, T, Walczak, AM, Gilbert, PB, Doria-Rose, NA, Huang, Y, Bloom, JD, Seaman, MS, Bjorkman, PJ, Klein, F (2025) Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy. Nat Immunol doi:10.1038/s41590-025-*Equal contributions.
Gieselmann, L*, DeLaitsch, AT*, Rohde, M*, Radford, C, Worczinski, J, Momot, A, Ahmadov, E, Burger, JA, Havenar-Daughton, C, Deshpande, S, Giovannoni, F, Corti, D, Kreer, C, Ercanoglu, MS, Schommers, P, Georgiev, I, West, AP, Knuefer, J, Stumpf, R, Kroidl, A, Geldmacher, C, Maganga, L, William, W, Ntinginya, NE, Hoelscher, M, Yang, Z, Wei, Q, Renfrow, M, Green, TJ, Novak, J, van Gils, M, Gristick, HB, Gruell, H, Bloom, JD, Seaman, MS, Bjorkman, P, Klein, F (2025) Identification of a broad and potent V3 glycan site bNAb targeting an N332gp120 glycan-independent epitope. bioRxiv 2025.09.05.674437; Nat Immunol, ms. accepted.i:10.1101/2025.09.05.674437 *Equal contributions.
Gristick, HB, Hartweger, H, Nishimura, Y, Gavor, E, Nagashima, K, Koranda, NS, Gnanapragasam, PNP, Kakutani, LM, Segovia, L, Donau, OK, Keeffe, JR, West, AP Jr, Martin, MA, Nussenzweig, MC, Bjorkman, PJ (2025) Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes. J Exp Med 222: e20250693. PMCID: PMC12341506 doi:10.1084/jem.20250693
Jiang J, Chen S, Tsou T, McGinnis CS, Khazaei T, Zhu Q, Park JH, Strazhnik IM, Vielmetter J, Gong Y, Hanna J, Chow ED, Sivak DA, Gartner ZJ, Thomson. M (2025) D-SPIN constructs gene regulatory network models from multiplexed scRNA-seq data revealing organizing principles of cellular perturbation response. bioRxiv [Preprint]. 2025 May 23:2023.04.19.537364. doi:10.1101/2023.04.19.537364.PMID: 37131803 Free PMC article. Preprint.
Munro, J, Melnyk, D, Afzal, M, Schimanski, L, Cohen, AA, Keeffe, JR, Bjorkman, PJ, James, WS, Townsend, AR, Tan, TK. (2025) Development of a Recombinant Single-Cycle Influenza Viral Vector as an Intranasal Vaccine against SARS-CoV-2 and SARS-like Betacoronaviruses. bioRxiv 2025.11.28.691177. doi:10.1101/2025.11.28.691177. PMCID: PMC12694603.
Olson, BA, Huey-Tubman, KE, Mao, Z, Hoffmann, MAG, Bjorkman, PJ, Murray, RM, Mayo, SL (2025) Recruiting ESCRT to single-chain heterotrimer peptide MHCI releases antigen-presenting vesicles that stimulate T cells selectively, Proc. Natl. Acad. Sci. U.S.A. 122 (51) e2501046122, doi:10.1073/pnas.2501046122
Skelly, AN*, Gristick, HB*, Li, H*, Gavor, E*, Connell, AJ, Kreider, EF, Marchitto, L, Hogarty, MP, Newby, ML, Allen, JD, Liu, W, West, AP Jr., Ayyanathan, K, Campion, MS, Winters, K, Gordon, CG, Osbaldeston, RA, Akeley, MJ, Li, Y, Singh, A, Cruickshank, K, Park, Y, Zhao, C, Li, X, Amereh, K, Itallie, EV, Carey, JW, Albertus, A, DeLaitsch, AT, Keeffe, JR, Lituchy, MG, Walsh, AA, Morris, DJ, Habib, R, Bibollet-Ruche, F, Mishra, N, Avillion, G, Koranda, NS, Plante, SJ, Martella, CL, Lora, J, Wang, EJD, Lewis, MG, Martin, MA, Nussenzweig, MC, Seaman, MS, Irvine, DJ, Wiehe, KJ, Haynes, BF, Wagh, K, Korber, BT, Andrabi, R, Crispin, M, Weissman, D, Bjorkman, PJ, Hahn, BH, Shaw, GM (2025) Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design. bioRxiv 2025.10.06.680687. doi:10.1101/2025.10.06.680687 *Equal contributions.
Tsoleridis, T, Fan, C, Park, EJ, Duncan, JD, Sharma, P, Wartnaby, S, Chappell, JG, Kipar, A, Bentley, EG, Kirby, A, Han, X, Coleman, CM, Santos IA, Bailey D, Flyak, AI, McClure, CP, Rho, S, Johansson, DX, Persson MAA, Tarr, AW, Haig, D, Stewart, JP, Bjorkman, PJ, Urbanowicz, RA, Ball, JK (2025) An ultra-long heavy chain bovine antibody neutralizes SARS-CoV-2 and reacts broadly with sarbecoviruses. bioRxiv PMCID: PMC12338560 doi:10.1101/2025.01.03.631215
Vasnarungruengkul P, Anaya MA, Lam AW, Gonzalez E, Zhang A, Wang ML, Wojtowicz WM, Zinn K, Vielmetter J (2025) An Automated End-to-End Workflow for Production of Secreted Proteins in Transfected Mammalian Cells. bioRxiv [Preprint]. Jul 13:2025.07.13.664612. doi:10.1101/2025.07.13.664612 PMID: 40672302 Free PMC article. Preprint.
Wang, E*, Cohen, AA*, Caldera, LF*, Keeffe, JR, Rorick, AV, Aida, YM, Gnanapragasam, PNP, Bjorkman, PJ, Chakraborty, AK (2025) Designed mosaic nanoparticles enhance cross-reactive immune responses in mice. Cell 188: 1036-1050.e11. PMCID: PMC11845252 doi:10.1016/j.cell.2024.12.015 *Equal contributions.
Youssef, N, Gurev, S, Ghantous, F, Brock, KP, Jaimes, JA, Thadani, NN, Dauphin, A, Sherman, AC, Yurkovetskiy, L, Soto, D, Estanboulieh, R, Kotzen, B, Notin, P, Kollasch, AW, Cohen, AA, Dross, SE, Erasmus, J, Fuller, DH, Bjorkman, PJ, Lemieux, JE, Luban, J, Seaman, MS, Marks, DS (2025) Computationally designed proteins mimic antibody immune evasion in viral evolution. Immunity. 58: 1411-1421.e6. doi:10.1016/j.immuni.2025.04.015
2024
Agrawal, P, Knudsen, ML, MacCamy, A, Hurlburt, NK, Khechaduri, A, Salladay, KR, Kher, GM, Kallur Siddaramaiah, L, Stuart, AB, Bontjer, I, Shen, X, Montefiori, D, Gristick, HB, Bjorkman, PJ, Sanders, RW, Pancera, M, Stamatatos, L (2024) Short CDRL1 in intermediate VRC01-like mAbs is not sufficient to overcome key glycan barriers on HIV-1 Env. J Virol 98: e00744240. PMCID: PMC11495006 doi:10.1128/jvi.00744-24
*Cohen, AA, *Keeffe, JR, Schiepers, A, Dross, SE, Greaney, AJ, Rorick, AV, Gao, H, Gnanapragasam, PNP, Fan, C, West, AP, Ramsingh, AI, Erasmus, JH, Pata, JD, Muramatsu, H, Pardi, N, Lin, PJC, Baxter, S, Cruz, R, Quintanar-Audelo, M, Robb, E, Serrano-Amatriain, C, Magneschi, L, Fotheringham, IG, Fuller, DH, Victora, GD, Bjorkman PJ (2024) Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals. Cell 187: 1–18. PMCID: PMC11460329 doi:10.1016/j.cell.2024.07.052. *Co-first authors.
Free-access pdf: https://www.sciencedirect.com/science/article/pii/S0092867424008468
DeLaitsch, AT, Keeffe, JR, Gristick, HB, Lee, JA, Ding, W, Liu, W, Skelly, AN, Shaw, GM, Hahn, BH, Bjorkman, PJ (2024) Neutralizing antibodies elicited in macaques recognize V3 residues on altered conformations of HIV-1 Env trimer. npj Vaccines 9: 240. PMCID: PMC11621127 doi:10.1038/s41541-024-01038-0
Free-access pdf: https://rdcu.be/d2vxq
Hills, RA, Tan, TK, Cohen, AA, Keeffe, JR, Keeble, AH, Gnanapragasam, PNP, Storm, KN, Rorick, AV, West, AP Jr., Hill, ML, Liu, S, Gilbert-Jaramillo, J, Afzal, M, Napier, A, Adams, G, James, WS, Bjorkman, PJ, Townsend, AR, Howarth, M (2024) Proactive vaccination using multiviral Quartet Nanocages to elicit broad anti-coronavirus responses. Nat. Nanotechnol 19: 1216-1223. PMCID: PMC11329374 doi:10.1038/s41565-024-01655-9.
Full-text access to view-only version: https://rdcu.be/dG35Ai:10.1128/jvi.01432-2
Rapp PB, Baccile JA, Galimidi RP, Vielmetter J (2024) Engineering Antigen-Specific Tolerance to an Artificial Protein Hydrogel. ACS Biomater Sci Eng. 2024 Apr 8;10(4):2188-2199. doi:10.1021/acsbiomaterials.3c01430. Epub 2024 Mar 13.PMID: 38479351
2023
Shay TF, Sullivan EE, Ding X, Chen X, Ravindra Kumar S, Goertsen D, Brown D, Crosby A, Vielmetter J, Borsos M, Wolfe DA, Lam AW, Gradinaru V. (2023) Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors. Sci Adv. 2023 Apr 21;9(16):eadg6618. doi:10.1126/sciadv.adg6618. Epub 2023 Apr 19. PMID: 37075114.
Braet, SM, Buckley, TSC, Venkatakrishnan, V, Dam, K-MA, Bjorkman, PJ, Anand, GS (2023) Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics eLife 12: e82584. PMCID: PMC10049203 doi:10.7554/eLife.82584
Dam K-MA, Fan, C, Yang, Z, Bjorkman, PJ (2023) Structural characterization of HIV-1 Env heterotrimers bound to one or two CD4 receptors reveals intermediate Env conformations. bioRxiv 2023.01.27.525985 doi:10.1101/2023.01.27.525985
Dam K-MA, Fan, C, Yang, Z, Bjorkman, PJ (2023) Intermediate conformations of CD4-bound HIV-1 Env heterotrimers. Nature 623: 1017–1025. PMCID: PMC10686819 doi:10.1038/s4dcu.be/dwp88
Gristick, HB, Hartweger, H, Loewe, M, van Schooten, J, Ramos, V, Oliviera, TY, Nishimura, Y, Koranda, NS, Wall, A, Yao, K-H, Poston, D, Gazumyan, A, Wiatr, M, Horning, M, Keeffe, JR, Hoffmann, MAG, Yang, Z, Abernathy, ME, Dam, KA, Gao, H, Gnanapragasam, PNP, Kakutani, LM, Pavlovitch-Bedzyk, AJ, Seaman, MS, Howarth, M, McGuire, AT, Stamatatos, L, Martin, MA, West, AP, Nussenzweig, MC, Bjorkman, PJ (2023) CD4 binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wild-type animals. Sci Immunol doi:10.1126/sciimmunol.ade6364.
Hoffmann, MAG, Yang, Z, Huey-Tubman, KE, Cohen, AA, Gnanapragasam, PNP, Nakatomi, LM, Storm, KN, Moon, WJ, Lin, PJC, West Jr AP, Bjorkman, PJ (2023) ESCRT recruitment to SARS-CoV-2 spike induces virus-like particles that improve mRNA vaccines, Cell 186: 2380-2391.e9. doi:10.1016/j.cell.2023.04.024 (open access link). See preview: Zost, SJ, Carnahan, RH. A budding new approach strengthens an important message (2023) Cell 186: 2283-2285. doi:10.1016/j.cell.2023.04.034.
Brehove M, Rogers C, Menon R, Minor P, Allington J, Lam A, Vielmetter J, Menon N. (2023) Cell monitoring with optical coherence tomography. Cytotherapy. 2023 Feb;25(2):120-124. doi:10.1016/j.jcyt.2022.09.008. Epub 2022 Oct21. PMID: 36274007doi:10.1016/j.cell.2023.04.024.
2022
Barnes, CO, Schoofs, T, Gnanapragasam PNP, Golijanin, J, Huey-Tubman, KE, Gruell, H, Schommers. P, Suh-Toma, N, Lee, YE, Lorenzi, JCC, Piechocka-Trocha, A, Scheid, JF, West Jr, AP, Walker, BD, Seaman, MS, Klein, F, Nussenzweig, MC, Bjorkman, PJ (2022) A naturally arising broad and potent CD4-binding site antibody with low somatic mutation. bioRxiv 2022.03.16.484662. doi:10.1101/2022.03.16.484662
Cohen, AA*, van Doremalen, N*, Greaney, AJ, Andersen, H, Sharma, A, Starr, TN, Keeffe, JR, Fan, C, Schulz, JE, Gnanapragasam, PNP, Kakutani, LM, West Jr., AP, Saturday, G, Lee YE, Gao, H, Jette, CA, Lewis, MG, Tan, TK, Townsend, AR, Bloom, JD, Munster, VJ, Bjorkman, PJ (2022) Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models. bioRxiv 2022.03.25.485875. *Co-first authors. doi:10.1101/2022.03.25.485875
Dam, K-MA, Barnes, CO, Gristick, HB, Schoofs, T, Nussenzweig, MC, Bjorkman, PJ (2022) HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design. bioRxiv 2022.03.25.485873. doi:10.1101/2022.03.25.485873
Dam, K-MA, Mutia, PS, Bjorkman, PJ (2022) Comparing methods for immobilizing HIV-1 SOSIPs in ELISAs that evaluate antibody binding. Sci Rep 12: 11172. PMCID: PMC9247892 doi:10.1038/s41598-022-15506-x
Fan, C, Cohen, AA, Park, M, Hung, AF-H., Keeffe, JR, Gnanapragasam, PNP, Lee, YE, Gao, H, Kakutani, LM, Wu, Z, Kleanthous, H, Malecek, KE, Williams, JC, Bjorkman, PJ (2022) Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bindconserved sarbecovirus epitopes. Immunity 55(12):2419-2435.e10 PMCID: PMC9606073 doi:10.1016/j.immuni.2022.10.019. Immune Epitope Database and Analysis Resource (IEDB), Reference ID 1041591: http://www.iedb.org/refId/1041591
Yang, Z, Dam K-MA, Bridges, MD, Hoffmann, MAG, DeLaitsch, AT, Gristick, HB, Escolano, A, Gautam, R, Martin, MA, Nussenzweig, MC, Hubbell, WL, Bjorkman, PJ (2022) Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer. Nat Commun 13: 732. PMCID: PMC8826976 doi:10.1038/s41467-022-28424-3
Tanaka, S, Olson, CA, Barnes, CO, Higashide, W, Gonzalez, M, Taft, J, Richardson, A, Martin-Fernandez, M, Bogunovic, D, Gnanapragasam, PNP, Bjorkman PJ, Spilman, P, Niazi, K, Rabizadeh, S, Soon-Shiong, P (2022) Rapid Identification of Neutralizing Antibodies against SARS-CoV-2 Variants by mRNA Display, Cell Reports 38: 110348. PMCID: PMC8769934 doi:10.1016/j.celrep.2022.110348
Vanshylla, K, Fan, C, Wunsch, M, Poopalasingam, N, Meijers, M, Kreer, C, Kleipass, F, Ruchnewitz, D, Ercanoglu, MS, Gruell, H, Münn, F, Pohl, K, Janicki, H, Nolden, T, Bartl, S, Stein, SC, Augustin, M, Dewald, F, Gieselmann, L, Schommers, P, Schulz, TF, Sander, LE, Koch, M, Luksza, M, Lässig, M, Bjorkman, PJ, Klein, F (2022) Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers, Cell Host & Microbe 30: 69-82. PMCID: PMC8683262 doi:10.1016/j.chom.2021.12.010
Weber, T, Potthoff, J, Bizu, S, Labuhn, M, Dold, L, Schoofs, T, Horning, M, Ercanoglu, MS, Kreer, C, Gieselmann, L, Vanshylla, K, Langhans, B, Janicki, H, Ströh, LJ, Knops, E, Nierhoff, D, Spengler, U, Kaiser, R, Bjorkman, PJ, Krey, T, Bankwitz, D, Pfeifer, N, Pietschmann, T, Flyak, AI, Klein, F (2022) Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization, Immunity 55: 341-355. doi:10.1016/j.immuni.2021.12.00
Yang, Z, Dam, K-MA, Gershoni, JM, Zolla-Pazner, S, Bjorkman, PJ (2022) Antibody recognition of CD4-induced open HIV-1 Env trimers. J Virology e01082-22. PMCID: PMC9769388 doi:10.1128/jvi.01082-22
2021
Agudelo, M, Martin Palus, M, Keeffe, JR, Bianchini, F, Svoboda, P, Salát, J, Peace, A, Gazumyan, A, Cipolla, M, Kapoor, T, Guidetti, F, Yao, K-H, Elsterová, J, Teislerová, D, Chrdle, A, Hönig, V, Oliviera, T, West, AP, Lee, YE, Rice, CM, MacDonald, MR, Bjorkman, PJ, Růžek, D, Robbiani, DF, Nussenzweig, MC (2021) Broad and Potent Neutralizing Human Antibodies to Tick-borne Flaviviruses Protect Mice from Disease. J Exp Med. 218: e20210236. PMCID: PMC8040517 doi:10.1084/jem.20210236
Abernathy, ME, Gristick, HB, Vielmetter, J, Keeffe, JR, Gnanapragasam, PNP, Lee, YE, Escolano, A, Gautam, R, Seaman, MS, Martin, MA, Nussenzweig, MC, Bjorkman, PJ (2021) Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope. npj Vaccines 6:126. PMCID: PMC8545924 doi:10.1038/s41541-021-00387-4
Cohen, AA, Gnanapragasam, PNP, Lee, YE, Hoffman, PR, Ou, S, Kakutani, LM, Keeffe, JR, Wu, H-J, Howarth, M, West, AP, Barnes, CO, Nussenzweig, MC, Bjorkman, PJ (2021) Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice. Science 371: 735-741. PMCID: PMC7928838 doi:10.1126/science.abf6840
Cohen, AA, Yang, Z, Gnanapragasam, P, Ou, S, Dam, K-M, Wang, H, Bjorkman, PJ (2021) Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers. PLoS One 16: e0247963. PMCID: PMC7932532 doi:10.1371/journal.pone.0247963
Escolano, A*, Gristick, HB*, Gautam, R*, DeLaitsch, AT*, Abernathy, ME, Yang, Z, Wang, H, Hoffmann, MAG, Nishimura, Y, Wang, Z, Koranda, N, Kakutani, LM, Gao, H, Gnanapragasam, PNP, Raina, H, Gazumyan, A, Cipolla, M, Oliveria, TY, Ramos, V, Irvine, DJ, Silva, M, West, AP, Keeffe, JR, Barnes, CO, Seaman, MS, Nussenzweig, MC, Martin, MA, Bjorkman, PJ (2021) Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env. Science Transl Med. 13: eabk1533. PMC8932345 (available on 2022-05-24) doi:10.1126/scitranslmed.abk1533. *Co-first authors.
Gaebler, C, Wang, Z, Lorenzi, JCC, Muecksch, F, Finkin, S, Tokuyama, M, Cho, A, Jankovic, M, Schaefer-Babajew, D, Oliveira, TY, Cipolla, M, Viant, C, Barnes, CO, Bram, Y, Breton, G, Hägglöf, T, Mendoza, P, Hurley, A, Turroja, M, Gordon, K, Millard, KG, Ramos, V, Schmidt, F, Weisblum, Y, Jha, D, Tankelevich, M, Martinez-Delgado, G, Yee, J, Patel, R, Dizon, J, Unson-O’Brien, C, Shimeliovich, I, Robbiani, DF, Zhao, Z, Gazumyan, A, Schwartz, RE, Hatziioannou, T, Bjorkman, PJ, Mehandru, S, Bieniasz, PD, Caskey, M, Nussenzweig, MC (2021) Evolution of Antibody Immunity to SARS-CoV-2. Nature 591: 639-644. PMCID: PMC7654855 doi:10.1038/s41586-021-03207-w
Greaney, AJ, Starr, TN, Barnes, CO, Weisblum, Y, Schmidt, F, Caskey, M, Gaebler, C, Cho, A, Agudelo, M, Finkin, S, Wang, Z, Poston, D, Muecksch, F, Hatziioannou, T, Bieniasz, PD, Robbiani, DF, Nussenzweig, MC, Bjorkman, PJ, Bloom, JD (2021) Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies. Nat Commun 12: 4196. PMCID: PMC8263750 doi:10.1038/s41467-021-24435-8
Jette, CA, Cohen, AA, Gnanapragasam, PNP, Muecksch, F, Lee, YE, Huey-Tubman, KE, Schmidt, F, Hatziioannou, T, Bieniasz, PD, Nussenzweig, MC, West, AP, Jr., Keeffe, JR, Bjorkman, PJ, Barnes, CO (2021) Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies. Cell Reports 36: 109760. PMCID: PMC8423902 doi:10.1016/j.celrep.2021.109760
Jette, CA, Barnes, CO, Kirk, SM, Melillo, B, Smith, III AB, Bjorkman, PJ (2021) Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation. Nat Commun 12: 1950. PMCID: PMC8007822 doi:10.1038/s41467-021-21816-x
Muecksch, F, Weisblum, Y, Barnes, CO, Schmidt, F, Schaefer-Babajew, D, Wang, Z, Lorenzi, JCC, Flyak, AI, DeLaitsch, AT, Huey-Tubman, KE, Hou, S, Schiffer, CA, Gaebler, C, Da Silva, J, Poston, D, Finkin, S, Cho, A, Cipolla, M, Oliveira, TY, Millard, KG, Ramos, V, Gazumyan, A, Rutkowska, M, Caskey, M, Nussenzweig, MC, Bjorkman, PJ, Hatziioannou, T, Bieniasz, PD (2021) Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations. Immunity 54: 1853-1868.e7. PMCID: PMC8323339 doi:10.1016/j.immuni.2021.07.008
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park S, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier R. (2021) B-cell genomics behind cross-neutralizing response against SARS-CoV-2 variants and SARS-CoV. Cell 184: P3205-3221.e24. PMCID: PMC8064835 doi:10.1016/j.cell.2021.04.032
Wang, Z, Schmidt, F, Weisblum, Y, Muecksch, F, Barnes, CO, Finkin, S, Schaefer-Babajew, D, Cipolla, M, Gaebler, C, Lieberman, JA, Yang, Z, Abernathy, ME, Huey-Tubman, KE, Hurley, A, Turroja, M, West, KA, Gordon, K, Millard, KG, Ramos, V, Da Silva, J, Xu, J, Colbert, RA, Patel, R, Dizon, J, Unson-O’Brien, C, Shimeliovich, I, Gazumyan, A, Caskey, M, Bjorkman, PJ, Casellas, R, Hatziioannou, T, Bieniasz, PD, Nussenzweig, MC (2021) mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants. Nature 592: 616–622. PMCID: PMC7836122 doi:10.1038/s41586-021-03324-6
2020
Barnes, C.O., West Jr., A.P., Huey-Tubman, K.E., Hoffmann, M.A.G., Sharaf, N.G., Hoffman, P.R., Koranda, N., Gristick, H.B., Gaebler, C., Muecksch, F., Cetrulo Lorenzi, J.C., Finkin, S., Hägglöf, T., Hurley, A., Millard, K.G., Weisblum, Y., Schmidt, F., Hatziioannou, T., Bieniasz, P.D., Caskey, M., Robbiani, D.F., Nussenzweig, M.C., Bjorkman, P.J (2020) Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies, Cell (2020), doi:10.1016/j.cell.2020.06.025
Cohen, AA, Yang, Z, Gnanapragasam, P, Ou, S, Dam, K-M, Wang, H, Bjorkman, PJ (2020) Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers. bioRxiv. doi:10.1101/2020.01.18.911388
Esswein, SR, Gristick, HB, Jurado, A, Peace, A, Keeffe, JR, Lee, YE, Voll, AV, MacDonald, MR, Rice, CM, Nussenzweig, MC, Robbiani, DF, Bjorkman, PJ (2020) Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody. Proc Natl Acad Sci USA, 117: 9865-9875 doi:10.1073/pnas.1919269117
Flyak, AI, Ruiz, SE, Salas, J, Rho, S, Bailey, JR, Bjorkman, PJ (2020) An ultralong CDRH2 in an HCV neutralizing antibody demonstrates structural plasticity of antibodies against the E2 glycoprotein. eLife 9: e53169 PMCID: PMC7064334 doi:10.7554/eLife.53169
Hoffmann MAG, Bar-On Y, Yang Z, Gristick HB, Gnanapragasam PNP, Vielmetter J, Nussenzweig MC, Bjorkman PJ. (2020) Nanoparticles presenting clusters of CD4 expose a universal vulnerability of HIV-1 by mimicking target cells. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18719-18728. doi:10.1073/pnas.2010320117. Epub 2020 Jul 20.PMID: 32690692
Ladinsky, MS, Gnanapragasam, PNP, Yang, Z, West Jr., AP, Kay, MS, Bjorkman PJ (2020) Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate. eLife 9: e58411. PMCID: PMC7394545 doi:10.7554/eLife.58411
Robbiani, DF, Gaebler, C, Muecksch, F, Lorenzi, JCC, Wang, Z, Cho, A, Agudelo, M, Barnes, CO, Gazumyan, A, Finkin, S, Hagglof, T, Oliveira, TY, Viant, C, Hurley, A, Hoffmann H-H, Millard, KG, Kost, RG, Cipolla, M, Gordon, K, Bianchini, F, Chen, ST, Ramos, V, Patel, R, Dizon, J, Shimeliovich, I, Mendoza, P, Hartweger, H, Nogueira, L, Pack, M, Horowitz, J, Schmidt, F, Weisblum, Y, Michailidis, E, Ashbrook, AW, Waltari, E, Pak, JE, Huey-Tubman, KE, Koranda, N, Hoffman, PR, West, Jr., AP, Rice, CM, Hatziioannou, T, Bjorkman, PJ, Bieniasz, PD, Caskey, M, Nussenzweig, MC (2020) Convergent antibody responses to SARS-CoV-2 in convalescent individuals. Nature, doi:10.1038/s41586-020-2456-9
*Schommers, P, *Gruell, H, *Abernathy, ME, Tran, M-K, Dingens, AS, Gristick, HB, Barnes, CO, Schoofs, T, Schlotz, M. Vanshylla, K, Kreer, C, Weiland, D, Holtick U, Scheid, C, Valter, MM, van Gils, MJ, Sanders RW, Vehreschild, JJ, Cornely, OA, Lehmann, C, Fatkenheuer, G, Seaman, MS, Bloom, JD, Bjorkman PJ, Klein, F. (2020) Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody. Cell 180: 471-489 *co-first authors. PMCID: PMC7042716 doi:10.1016/j.cell.2020.01.010
Van Rompay, KKA, Coffey, LL, Kapoor, T, Gazumyan, A, Keesler, RI, Jurado, A, Peace, A, Agudelo, M, Watanabe, J, Usachenko, J, Singapuri, A, Immareddy, R, Ardeshir, A, Stuart, JB, Bournazos, S, Ravetch, JV, Balderes, PJ, Lorenz, IC, Esswein, SR, Keeffe, JR, Bjorkman, PJ, Wang, Q, Rice, CM, MacDonald, MR, Nussenzweig, MC, Robbiani, DF (2020) A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques. Proc Natl Acad Sci USA, 117: 7981-7989 PMCID PMC7149495 doi:10.1073/pnas.2000414117
Wojtowicz WM, Vielmetter J, Fernandes RA, Siepe DH, Eastman CL, Chisholm GB, Cox S, Klock H, Anderson PW, Miller JJ, Glaser SM, Bragstad ML, Vance J, Lam AW, Lesley SA, Zinn K, Garcia KC. (2020) A Human IgSF Cell-Surface Interactome Screen Reveals a Complex Network of Protein-Protein Interactions. Cell 2020 Aug 20;182(4):1027-1043.e17. doi:10.1016/j.cell.2020.07.025. PMID: 32822567
> For General Inquiries-- pec@caltech.edu