Applying Chemical Physics to Biological Problems

Heath Group news

Wei's work on single-cell phosphoproteomics and targeted combination therapy in glioblastoma was published in Cancer Cell and featured in the current issue! Nataly's paper on the identification of tumor-specific unbalanced processes has also been published in Journal of Physical Chemistry B!

Ryan's paper on the degradation of Akt has been published! Min's paper on supramolecular probes for assessing glutamine uptake at the single cell level is now in JACS! Congratulations!

A big congratulations to our high school students John Heath, Joseph (Jun Hyuk) Oh, and Emma Winson, who have advanced as Regional Finalists in the 2015 Siemens Competition! John, Joseph, and Emma spent their summer researching KRAS under the mentorship of Ryan Henning. We're rooting for you!

Dr. William Dichtel (a former postdoc who is an Associate Professor at Cornell University) has been selected for the prestigious MacArthur Fellowship! CONGRATULATIONS!

Samir and Arundhati's paper on the general epitope targeting strategy with macrocyclic peptides has been published in Angewandte Chemie Int. Ed.. Congrats to them and the rest of the capture agents subgroup!

Jake and Young Shik's paper was accepted to Technology!

Congratulations to alumni Dr. Nataly Kravchenko-Balasha who is a new assistant professor at The Hebrew University of Jerusalem!

Congratulations to Alex and Kaycie! Alex is graduating and starting an Insight Data Science Fellowship next week, and Kaycie is starting her post-doctoral position at EPFL in Switzerland next week. Good luck with everything guys, we'll miss you!

Blake's paper on using the tertiary structure of Botulinum toxin to assemble an inhibitor was just published in Angewandte Chemie.

Congratulations to Liz for receiving an NSF fellowship!

Kaycie's paper on epitope targeting the E17K point mutation was just published in Nature Chemistry and featured on the Caltech homepage!

Min's paper on quantifying metabolites from single cells was just published in JACS.

The Heath lab welcomes our newest members Amy McCarthy and Liz Holman, both graduate students in Chemistry.


Predictive Cancer Therapy

Engineered T Cell Immunotherapy

Department of Defense Capture Agents

Cancer Capture Agents

Developing World Diagnostics

Our group works on applications of chemical physics to fundamental biology and translational medicine - with a clear focus on oncology. We are comprised of a diverse, talented, and highly motivated group of graduate students and postdoctoral researchers. Our graduate students come from the physical, organic, and inorganic areas of Chemistry, Chemical Engineering, and from Physics, the Caltech/UCLA joint M.D./Ph.D. program, Bioengineering, Biology, and Materials Science. Our postdoctoral researchers have similarly diverse backgrounds.

Furthermore, we collaborate extensively with groups at Caltech, groups within the UCLA medical school, and groups in Seattle, Europe, Israel, and South Korea. Our labs occupy about 60% of the basement level of the Noyes Laboratory of Chemical Physics, as well as a small laboratory at UCLA devoted to translational medicine.

One thing that draws our research projects together is that we focus on the fundamental scientific bottlenecks that, if solved, can provide keys toward solving much larger problems. Those problems can be in energy conversion technologies, translational medicine, or basic oncology studies. We believe in working hard, playing hard, and that our science should be fun.

The Heath group is always looking for talented and passionate scientists interested in investigating the interface between chemical physics and biology.

Email us!


Recent Publications

Epitope-targeting a Single Amino Acid Point Mutation in Akt1

Kaycie M. Deyle, Blake Farrow, Ying Qiao Hee, Jeremy Work, Michelle Wong, Bert Lai, Aiko Umeda, Steven Millward, Arundhati Nag, Samir Das, James R. Heath
Protein-targeting strategy develops a selective inhibitor of the E17K mutation in the PH Domain of Akt1
Nature Chemistry, 2015, 10.1038/nchem.2223
Highlighted by Caltech News, GenomeWeb, Indi Molecular.

Simultaneously Quantifying Metabolites and Proteins from Single Cells

Min Xue, Wei Wei, Yapeng Su, JungWoo Kim, Young Shik Shin, Wilson X. Mai, David A. Nathanson and James R. Heath
Chemical Methods for the Simultaneous Quantitation of Metabolites and Proteins from Single Cells
Journal of the American Chemical Society, 2015, 10.1021/jacs.5b00944

Contact Us

California Institute of Technology
1200 E California Blvd
Pasadena, CA 91125
M/C 127-72
Lab Phone: 626-395-8919
Professor Heath: heath@caltech.edu
Administrative Assistant: Elyse Garlock - egarlock@caltech.edu
Webmaster: jingxin.liang@caltech.edu