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Applying Chemical Physics to Biological Problems

Heath Group news

4/16/2015
Congratulations to Liz for receiving an NSF fellowship!

4/13/2015
Kaycie's paper on epitope targeting the E17K point mutation was just published in Nature Chemistry and featured on the Caltech homepage!

3/19/2015
Min's paper on quantifying metabolites from single cells was just published in JACS.

10/01/2014
The Heath lab welcomes our newest members Amy McCarthy and Liz Holman, both graduate students in Chemistry.

Research

Predictive Cancer Therapy

Engineered T Cell Immunotherapy

Department of Defense Capture Agents

Cancer Capture Agents

Developing World Diagnostics


Our group works on applications of chemical physics to fundamental biology and translational medicine - with a clear focus on oncology. We are comprised of a diverse, talented, and highly motivated group of graduate students and postdoctoral researchers. Our graduate students come from the physical, organic, and inorganic areas of Chemistry, Chemical Engineering, and from Physics, the Caltech/UCLA joint M.D./Ph.D. program, Bioengineering, Biology, and Materials Science. Our postdoctoral researchers have similarly diverse backgrounds.

Furthermore, we collaborate extensively with groups at Caltech, groups within the UCLA medical school, and groups in Seattle, Europe, Israel, and South Korea. Our labs occupy about 60% of the basement level of the Noyes Laboratory of Chemical Physics, as well as a small laboratory at UCLA devoted to translational medicine.

One thing that draws our research projects together is that we focus on the fundamental scientific bottlenecks that, if solved, can provide keys toward solving much larger problems. Those problems can be in energy conversion technologies, translational medicine, or basic oncology studies. We believe in working hard, playing hard, and that our science should be fun.

The Heath group is always looking for talented and passionate scientists interested in investigating the interface between chemical physics and biology.

Email us!

Members


Recent Publications

Epitope-targeting a Single Amino Acid Point Mutation in Akt1

Kaycie M. Deyle, Blake Farrow, Ying Qiao Hee, Jeremy Work, Michelle Wong, Bert Lai, Aiko Umeda, Steven Millward, Arundhati Nag, Samir Das, James R. Heath
Protein-targeting strategy develops a selective inhibitor of the E17K mutation in the PH Domain of Akt1
Nature Chemistry, 2015, 10.1038/nchem.2223
Highlighted by Caltech News, GenomeWeb, Indi Molecular.

Simultaneously Quantifying Metabolites and Proteins from Single Cells

Min Xue, Wei Wei, Yapeng Su, JungWoo Kim, Young Shik Shin, Wilson X. Mai, David A. Nathanson and James R. Heath
Chemical Methods for the Simultaneous Quantitation of Metabolites and Proteins from Single Cells
Journal of the American Chemical Society, 2015, 10.1021/jacs.5b00944


Click here to see all publications.

Contact Us

California Institute of Technology
1200 E California Blvd
Pasadena, CA 91125
M/C 127-72
Lab Phone: 626-395-8919
Professor Heath: heath@caltech.edu
Administrative Assistant: Elyse Garlock - egarlock@caltech.edu
Webmasters: asutherl@caltech.edu, jingxin.liang@caltech.edu