Pamela J. Bjorkman Lab
Bil Clemons Lab
Andre Hoelz Lab
Grant Jensen Lab
Stephen L. Mayo Lab
Douglas C. Rees Lab

Molecular Observatory for Structural Molecular Biology
Sequence and Structure Analysis Facility
SSRL beamtime/Crystal trays
Protein Expression Facility
History of Women in Crystallography

History of Structural Biology at Caltech

The modern field of Structural Biology essentially originated at Caltech in the 1940's with Linus Pauling. Pauling pioneered the structure -based approach to the study of biological systems that has formed the basis for most subsequent advances in understanding the molecular mechanisms of biological systems. The objective of the present Structural Biology group at Caltech is to continue in the tradition established by Pauling to use the information obtained from high resolution structures to understand the molecular basis of biological processes. Current protein crystallographic efforts focus upon cell surface proteins involved in the immune response, nervous system and signal transduction pathways, integral membrane proteins, metalloproteins, and hyper- thermostable proteins. The Center for Macromolecular Crystallography at Caltech includes modern equipment for the collection and analysis of x-ray diffraction data derived from crystals of macromolecules. X-ray data collection hardware includes two x-ray generators, and two phosphor imaging plate detectors. Computational analysis is done using Silicon Graphics and Digital Equipment alpha workstations. NMR facilities include a 600 MHz NMR.

Structural Biology Groups Around the World

Crystallography Resources

Brookhaven National Laboratory

Protein Data Bank

High Flux Beam Reactor

National Synchrotron Light Source

CHESS, Cornell High Energy Synchrotron Source

International Union of Crystallography

The Salk Institute, Structural Biology Laboratory

World-Wide Web Virtual Library: Crystallography

UCLA, DOE Structural Biology Groups

Synchrotron beamline information from Biosync

California Institute of Technology
1200 E. California Blvd.
Pasadena, CA 91125