Normal Unperturbed Immature Thymocyte Gene Expression

Sets 4&5" adult DN thymocyte subsets, analyzed summer 2005

Data published in: E.-S. David-Fung, M. A. Yui, M. Morales, H. Wang, T. Taghon, R. A. Diamond, and E. V. Rothenberg,Immunological Reviews 2006; 209:212-236 (exception Runx2 not published yet)

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Efects of forced PU.1 expression in fetal thymocytes in the presence or absence of Notch signals

Data from C.B. Franco, D. D. Scripture-Adams, I. Proekt, T. Taghon, A. H. Weiss, M. A. Yui, S. L. Adams, R. A. Diamond, and E. V. Rothenberg, Proc Natl Acad Sci USA 2006; 103:11993-11998

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PU.1 effect per stage

 Data from C.B. Franco, D. D. Scripture-Adams, I. Proekt, T. Taghon, A. H. Weiss, M. A. Yui, S. L. Adams, R. A. Diamond, and E. V. Rothenberg, Proc Natl Acad Sci USA 2006; 103:11993-11998

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• Link to Tab Separated Values text format file: PU.1 vs Control Averaged Data
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Data on the short-term effects of removing fetal thymocytes from Notch-Delta interactions

Data compiled from two published studies, Franco et al. 2006 PNAS ("Chris data") and Taghon et al. 2007 Nat. Immunol. ("Mary data")

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Data for effects of overexpression of GATA-3 wildtype and the partial agonist "GATA3-KRR" mutant in fetal thymocytes.

Data from Taghon et al. 2007 Nat. Immunol.

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• Link to Tab Separated Values Text Format File: Overexpressed Gata3 and KRR mutant
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Gene Expression Pattern Comparison:

"LSK" (progenitor-like bone marrow cells) versus Pro-T, Pro-B, and pre-myeloid cells

Data from Tydell et al. 2007, The Journal of Immunology

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Gene Expression Pattern Comparison:

"LSK" (progenitor-like bone marrow cells) versus Cells of five DN Stages

Data from Tydell et al. 2007, The Journal of Immunology

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Gene Expression Pattern Comparison:

Intrathymic T Cell Precursors vs. Myeloid Progenitors

Data from Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology

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• Link to Tab Separated Values Text Format Files: All Data and High Quality QPCR Selection