Bi250c Topics in Systems Neuroscience
Spring 2017
Instructor: Thanos Siapas
TA: Koichiro Kajikawa
Class Time: Wed 2:00-4:55pm in 101 Kerckhoff
Apr 5
Week 1: Introduction
Optional Reading
- Cole and Curtis (1939), Electric impedance of the squid giant axon during activity
- Hodgkin et al. (1952), Measurement of current-voltage relations in the membrane of the giant axon of Loligo
- Hodgkin et al. (1952), Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo
- Hodgkin et al. (1952), The components of membrane conductance in the giant axon of Loligo
- Hodgkin et al. (1952), The dual effect of membrane potential on sodium conductance in the giant axon of Loligo
- Hodgkin et al. (1952), A quantitative description of membrane current and its application to conduction and excitation in nerve
- Huxley (2002), From overshoot to voltage clamp
- Squid and giant nerve fiber videos
Apr 12
Week 2: Plasticity
- (A) Markram et al. (1997), Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
- (B) Cassenaer & Laurent (2007), Hebbian STDP in mushroom bodies facilitates the synchronous flow of olfactory information in locusts, supplementary
- (C) Cassenaer & Laurent (2012), Conditional modulation of spike-timing-dependent plasticity for olfactory learning, supplementary
Apr 19
Week 3: Hippocampus and space
- (C) O'Keefe & Recce (1993), Phase Relationship Between Hippocampal Place Units and the EEG Theta Rhythm
- (A) Rich et al. (2014), Large environments reveal the statistical structure governing hippocampal representations, supplementary
- (B) Aronov et al. (2017), Mapping of a non-spatial dimension by the hippocampal–entorhinal circuit
Apr 26
Week 4: Associative Memory
- (B) Hopfield (1982), Neural networks and physical systems with emergent collective computational abilities
- (C) Nakazawa et al., (2002), Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall
- (A) Guzman et al. (2016), Synaptic mechanisms of pattern completion in the hippocampal CA3 network
May 3
Week 5: Oscillation
- (C) Watt et al. (2009), Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity, supplementary, movie 1, 2
- (B) Lubenov & Siapas (2009), Hippocampal theta oscillations are travelling waves, supplementary, movie
- (A) Agarwal et al., (2014), Spatially Distributed Local Fields in the Hippocampus Encode Rat Position, supplementary
May 10
Week 6: REM sleep
May 17
Week 7: Ripples
- (A) Foster & Wilson (2006), Reverse replay of behavioural sequences in hippocampal place cells during the awake state, supplementary
- (C) Roux et al., (2017), Sharp wave ripples during learning stabilize the hippocampal spatial map
- (B) Hinton et al., (1995), The "Wake-Sleep" Algorithm for Unsupervised Neural Networks
May 24
Week 8: Cerebellum
- (B) Dean et al., (2010), The cerebellar microcircuit as an adaptive filter: experimental and computational evidence
- (C) Wagner et al., (2017), Cerebellar granule cells encode the expectation of reward
- (A) Giovannucci et al., (2017), Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning
May 31
Week 9: Structure/function
- (C) Rancz et al. (2011), Transfection via whole-cell recording in vivo: bridging single-cell physiology, genetics and connectomics, supplementary
- (B) Brigmann, Helmstaedter & Denk (2011), Wiring specificity in the direction-selectivity circuit of the retina, supplementary, image data
- (A) Bargmann & Marder (2013), From the connectome to brain function
June 7
Week 10: Final Projects
Contact
Mailing list
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caltech.eduInstructor Thanos Siapas: thanos
caltech.edu