Bi250c Topics in Systems Neuroscience
Spring 2014
Instructor: Thanos Siapas
TA: Britton Sauerbrei
Class Time: Wed 2:00-4:55pm in 101 Kerckhoff
Apr 2
Week 1: Introduction
Optional Reading
- Cole and Curtis (1939), Electric impedance of the squid giant axon during activity
- Hodgkin et al. (1952), Measurement of current-voltage relations in the membrane of the giant axon of Loligo
- Hodgkin et al. (1952), Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo
- Hodgkin et al. (1952), The components of membrane conductance in the giant axon of Loligo
- Hodgkin et al. (1952), The dual effect of membrane potential on sodium conductance in the giant axon of Loligo
- Hodgkin et al. (1952), A quantitative description of membrane current and its application to conduction and excitation in nerve
- Huxley (2002), From overshoot to voltage clamp
- Squid and giant nerve fiber videos
Apr 9
Week 2: Imaging
Guest Lecturer: Dr. Laurent Moreaux
Part 1: Introduction to Imaging
Part 2: Optical Imaging Techniques
Apr 16
Week 3: Spike-Timing-Dependent Plasticity
- (A)
Markram et al. (1997),
Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
- (B) Cassenaer & Laurent (2007), Hebbian STDP in mushroom bodies facilitates the synchronous flow of olfactory information in locusts, supplementary 1
- (C) Pawlak et al. (2013), Changing the responses of cortical neurons from sub- to suprathreshold using single spikes in vivo
Apr 23
Week 4: The Hippocampus and Space
- (A) O'Keefe & Recce (1993), Phase Relationship Between Hippocampal Place Units and the EEG Theta Rhythm
- (B) Epsztein, Brecht, & Lee (2011), Intracellular Determinants of Hippocampal CA1 Place and Silent Cell Activity in a Novel Environment, supplementary 1
- (C) Foster & Wilson (2011), Reverse replay of behavioural sequences in hippocampal place cells during the awake state , supplementary 1 , supplementary 2
Apr 30
Week 5: Structure-Function Relationships
- (C) Rancz et al. (2011), Transfection via whole-cell recording in vivo: bridging single-cell physiology, genetics and connectomics, supplementary 1
- (A) Brigmann, Helmstaedter & Denk (2011), Wiring specificity in the direction-selectivity circuit of the retina, supplementary 1
- (B) Burgalossi et al. (2011), Microcircuits of functionally identified neurons in the rat medial entorhinal cortex., supplementary 1
May 7
Week 6: Neuronal Oscillations
- (B) Amzica & Steriade (1995), Short- and Long-Range Neuronal Synchronization of the Slow Cortical Oscillation,
- (A) Lubenov & Siapas (2009), Hippocampal Theta Oscillations are Travelling Waves, supplementary 1, supplementary 2, supplementary 3, supplementary 4
- (C) Mathy et al. (2009), Encoding of Oscillations by Axonal Bursts in Inferior Olive Neurons, supplementary 1,
May 14
Week 7: The Cerebellum
- (B) Loewenstein et al. (2005), Bistability of cerebellar Purkinje cells modulated by sensory stimulation, supplementary 1, supplementary 2, supplementary 3, comment
- (C) Medina & Lisberger (2008), Links from complex spikes to local plasticity and motor learning in the cerebellum of awake-behaving monkeys., supplementary 1
- (A) Arenz et al. (2008), The contribution of single synapses to sensory representation in vivo., supplementary 1 supplementary 2
May 21
Week 8: Evolution of Cortex
Guest Lecturer: Dr. Paul Rhodes, EvolvedMachines
- (Background reading) Ulinski (1990), The Cerebral Cortex of Reptiles,
- (A) Reiner & Northcutt (2000), Succinic Dehydrogenase Histochemistry Reveals the Location of the Putative Primary Visual and Auditory Areas within the Dorsal Ventricular Ridge of Sphenodon punctatus,
- (B) Marin-Padila (2014), The mammalian neocortex new pyramidal neuron: a new conception,
May 28
Week 9: Sleep
June 4
Week 10: Final Projects
Contact
Mailing list
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caltech.eduInstructor Thanos Siapas: thanos
caltech.edu