Bi250c Topics in Systems Neuroscience

Apr 3

Week 1: Introduction

Optional Reading

• Cole and Curtis (1939), Electric impedance of the squid giant axon during activity
• Hodgkin et al. (1952), Measurement of current-voltage relations in the membrane of the giant axon of Loligo
• Hodgkin et al. (1952), Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo
• Hodgkin et al. (1952), The components of membrane conductance in the giant axon of Loligo
• Hodgkin et al. (1952), The dual effect of membrane potential on sodium conductance in the giant axon of Loligo
• Hodgkin et al. (1952), A quantitative description of membrane current and its application to conduction and excitation in nerve
• Huxley (2002), From overshoot to voltage clamp
• Squid and giant nerve fiber videos

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Apr 10

Week 2: Optical Imaging

Guest Lecturer: Dr. Laurent Moreaux

Part 1: Introduction to optical imaging

Part 2: Optical Imaging Techniques

• (A) Yaksi & Friedrich (2006), Reconstruction of firing rate changes across neuronal populations by temporally deconvolved Ca2+ imaging, supplementary 1, 2, 3, 4, 5, 6
• (B) Jia et al. (2010), Dendritic organization of sensory input to cortical neurons in vivo, supplementary 1

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Apr 17

Week 3: Electrophysiology and Optogenetics

Part 1: Introduction to electrophysiology

Part 2: Optogenetics

• (A) Adamantidis et al. (2007), Neural substrates of awakening probed with optogenetic control of hypocretin neurons
  
• (B) TBD
• Optional review: Fenno et al. (2011), The Development and Application of Optogenetics

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Apr 24

Week 4: Spike Time Dependent Plasticity

• (A) Markram et al. (1997), Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
• (B) Cassenaer & Laurent. (2007), Hebbian STDP in mushroom bodies facilitates the synchronous flow of olfactory information in locusts, supplementary
• (C) Jacob et al. (2007), Spike Timing-Dependent Synaptic Depression in the In Vivo Barrel Cortex of the Rat, supplementary 1, 2, 3, 4
• Optional reading: Markram et al. (2011), A history of spike-timing-dependent plasticity

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May 1

Week 5: Maps of Space

• (A) O'Keefe & Recce (1993), Phase Relationship Between Hippocampal Place Units and the EEG Theta Rhythm
• (B) Harvey et al. (2009), Intracellular dynamics of hippocampal place cells during virtual navigation, supplementary 1
• (C) Epsztein et al. (2011), Intracellular Determinants of Hippocampal CA1 Place and Silent Cell Activity in a Novel Environment, supplementary 1

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May 8

Week 6: Oscillations and Traveling Waves

• (A) Ermentrout & Kleinfeld (2001), Traveling Electrical Waves in Cortex: Insights from Phase Dynamics and Speculation on a Computational Role
• (B) Lubenov & Siapas (2009), Hippocampal Theta Oscillations are Traveling Waves, supplementary 1
• (C) Watt et al. (2009), Traveling Waves in Developing Cerebellar Cortex Mediated by Asymmetrical Purkinje Cell Connectivity, supplementary 1, 2, 3, 4

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May 15

Week 7: Evolution of Cortex

Guest Lecturer: Dr. Paul Rhodes, EvolvedMachines

• (C) Ulinski (1990), The Cerebral Cortex of Reptiles
• (B) Reiner & Northcutt (2000), Succinic Dehydrogenase Histochemistry Reveals the Location of the Putative Primary Visual and Auditory Areas within the Dorsal Ventricular Ridge of Sphenodon punctatus
• (A) Literature search, presentation and discussion on the following questions:
  1. Did the 6-layer neocortex evolve from the 3-layer pallium?
  2. What functional advantages might have driven evolution from 3-layer to 6-layer cortex?

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May 22

Week 8: Sleep and Plasticity

• (B) Dave et al. (2000), Song Replay During Sleep and Computational Rules for Sensorimotor Vocal Learning, supplementary 1
• (C) Vyazovskiy et al. (2009), Cortical Firing and Sleep Homeostasis, supplementary 1
• (A) Aton et al. (2009), Mechanisms of Sleep-Dependent Consolidation of Cortical Plasticity, supplementary 1

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May 29

Week 9: Network Anatomy vs Function

• (C) Rancz et al. (2011), Transfection via whole-cell recording in vivo: bridging single-cell physiology, genetics and connectomics, supplementary
• (A) Briggman et al. (2011), Wiring specificity in the direction-selectivity circuit of the retina, supplementary, image data
• (B) Jiang et al. (2013), The organization of two new cortical interneuronal circuits, supplemtary1, movie 1, movie 2

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June 5

Week 10: Final Projects

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