Bi250c Topics in Systems Neuroscience
Spring 2012
Instructor: Thanos Siapas
TA: Andreas Hoenselaar
Class Time: Wed 2:00-4:55pm in 101 Kerckhoff
Apr 4
Week 1: Introduction
Optional Reading
- Cole and Curtis (1939), Electric impedance of the squid giant axon during activity
- Hodgkin et al. (1952), Measurement of current-voltage relations in the membrane of the giant axon of Loligo
- Hodgkin et al. (1952), Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo
- Hodgkin et al. (1952), The components of membrane conductance in the giant axon of Loligo
- Hodgkin et al. (1952), The dual effect of membrane potential on sodium conductance in the giant axon of Loligo
- Hodgkin et al. (1952), A quantitative description of membrane current and its application to conduction and excitation in nerve
- Huxley (2002), From overshoot to voltage clamp
- Squid and giant nerve fiber videos
Apr 11
Week 2: Optical Imaging
Part 1: Introduction to optical imaging (Laurent Moreaux)
Part 2: Optical Imaging Techniques
Apr 18
Week 3: Electrophysiology and Optogenetics
Part 1: Introduction to electrophysiology (Thanos Siapas)
Part 2: Optogenetics
-
(A) Adamantidis et al. (2007),
Neural substrates of awakening probed with optogenetic control of hypocretin neurons
- (B) Cardin et al. (2009), Driving fast-spiking cells induces gamma rhythm and controls sensory responses
- Optional review: Fenno et al. (2011), The Development and Application of Optogenetics
Apr 25
Week 4: Spike Time Dependent Plasticity
- (A) Markram et al. (1997), Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
- (B) Cassenaer & Laurent. (2012), Conditional modulation of STDP for olfactory learning, supplementary 1
- (C) Lubenov & Siapas. (2008), Decoupling through synchrony in neuronal circuits with propagation delays, supplementary 1
- Optional reading: Markram et al. (2011), A history of spike-timing-dependent plasticity
May 2
Week 5: Maps of Space
- (A) O'Keefe & Recce (1993), Phase Relationship Between Hippocampal Place Units and the EEG Theta Rhythm
- (B) Harvey et al. (2009), Intracellular dynamics of hippocampal place cells during virtual navigation, supplementary 1
- (C) Hafting et al. (2005), Microstructure of a spatial map in the entorhinal cortex, supplementary 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
May 9
Week 6: Oscillations and Traveling Waves
- (A) Ermentrout & Kleinfeld (2001), Traveling Electrical Waves in Cortex: Insights from Phase Dynamics and Speculation on a Computational Role
- (B) Lubenov & Siapas (2009), Hippocampal Theta Oscillations are Traveling Waves, supplementary 1
- (C) Watt et al. (2009), Traveling Waves in Developing Cerebellar Cortex Mediated by Asymmetrical Purkinje Cell Connectivity, supplementary 1, 2, 3, 4
May 16
Week 7: Evolution of Cortex
Guest Lecturer: Paul Rhodes, EvolvedMachines
- (A) Ulinski (1990), The Cerebral Cortex of Reptiles
- (B) Reiner & Northcutt (2000), Succinic Dehydrogenase Histochemistry Reveals the Location of the Putative Primary Visual and Auditory Areas within the Dorsal Ventricular Ridge of Sphenodon punctatus
- (C) Literature search, presentation and discussion on the following questions:
- Did the 6-layer neocortex evolve from the 3-layer pallium?
- What functional advantages might have driven evolution from 3-layer to 6-layer cortex?
May 30
Week 9: Network Anatomy vs Function
- (A) Rancz et al. (2011), Transfection via whole-cell recording in vivo: bridging single-cell physiology, genetics and connectomics, supplementary
- (B) Briggman et al. (2011), Wiring specificity in the direction-selectivity circuit of the retina, supplementary, image data
- (C) Bargmann (2012), Beyond the connectome: How neuromodulators shape neural circuits
Contact
Mailing list
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caltech.eduInstructor Thanos Siapas: thanos
caltech.edu