Bi250b
Topics in Systems Neuroscience
Spring, 2011

Class Time
Wed 2:00-4:55pm in 101 Kerckhoff
Instructor
Thanos Siapas : thanoscaltech.edu
TA
Julie Cho: julieccaltech.edu

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Group lists



Mar 30: Introduction

Apr 6: Methods 1: Optical Imaging

Part 1. Introduction to optical imaging, Laurent Moreaux
Part 2.

  1. (A) Yaksi & Friedrich (2006), Reconstruction of firing rate changes across neuronal populations by temporally deconvolved Ca2+ imaging, supplementary 1, 2, 3, 4, 5, 6
  2. (B) Bradley et al. (2009), Submillisecond optical reporting of membrane potential in situ using a neuronal tracer dye

Apr 13: Methods 2

Part 1. Introduction to electrophysiological techniques (Thanos)
Part 2. Optogenetics

  1. (A) Adamantidis et al. (2007), Neural substrates of awakening probed with optogenetic control of hypocretin neurons
  2. (B) Cardin et al. (2009), Driving fast-spiking cells induces gamma rhythm and controls sensory responses

Apr 20: Spike Time Dependent Plasticity
  1. (A) Markram et al. (1997), Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
  2. (B) Cassenaer & Laurent. (2007), Hebbian STDP in mushroom bodies facilitates the synchronous flow of olfactory information in locusts
  3. (C) Lubenov & Siapas. (2008), Decoupling through synchrony in neuronal circuits with propagation delays


Apr 27:The evolution of cortex (Paul Rhodes)

  1. (A) Ulinski, �The Cerebral Cortex of Reptiles�
  2. (B) Reiner & Northcutt, �Succinic Dehydrogenase Histochemistry Reveals the Location of the Putative Primary Visual and Auditory Areas within the Dorsal VentricularRidge of Sphenodon punctatus�
  3. (C) Literature search and will present and lead discussion on: (1) Did the 6-layer neocortex evolve from the 3-layer pallium? (2) What functional advantages might have driven evolution from 3 to 6-layer cortex?


May 4: Sleep and Model Organisms

  1. (A) Nitz et al. (2002), Electrophysiological Correlates of Rest and Activity in Drosophila melanogaster
  2. (B) Prober et al. (2006) Hypocretin/Orexin Overexpression Induces Insomnia-Like Phenotype in Zebrafish
  3. (C) Raizen et al. (2008) Lethargus is a Caenorhabditis elegans Sleep-like State


May 11: REM Sleep

  1. (A) Crick and Mitchison (1983), The function of dream sleep
  2. (B) Siegel (2001), The REM Sleep-Memory Consolidation Hypothesis
  3. (C) Louie and Wilson (2001), Temporally Structured Replay of Awake Hippocampal Ensemble Activity during Rapid Eye Movement Sleep


May 18: Traveling Waves

  1. (A) Ermentrout and Kleinfeld (2001), Traveling Electrical Waves in Cortex: Insights from Phase Dynamics and Speculation on a Computational Role
  2. (B) Lubenov and Siapas (2009), Hippocampal Theta Oscillations are Travelling Waves
  3. (C) Watt et al. (2009), Traveling Waves in Developing Cerebellar Cortex Mediated by Asymmetrical Purkinje Cell Connectivity


May 25: Maps of Space

  1. (A) Epsztein et. al (2011), Intracellular Determinants of Hippocampal CA1 Place and Silent Cell Activity in a Novel Environment
  2. (B) Hafting et al. (2005), Microstructure of a spatial map in the entorhinal cortex
    [supplementary material 1] [2] [3] [4] [5] [6] [7] [8] [9] [10]
  3. (C) Burgess et al. (2007), An Oscillatory Interference Model of Grid Cell Firing


June 1: Final Project

Group C Tim M., Alysia
Group B Brad, Jessica, Rachel
Group A Rebecca, Ruzbeh, Jeremy


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