Bi250b
Topics in Systems Neuroscience
Winter, 2010

Class Time
Wed 2:00-4:30pm in 101 Kerckhoff
Instructor
Thanos Siapas : thanoscaltech.edu
TA
Julie Cho: julieccaltech.edu

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Group lists



Jan 6: Introduction

  1. Cole and Curtis (1939), Electric impedance of the squid giant axon during activity
  2. Hogkin et al. (1952), Measurement of current-voltage relations in the membrane of the giant axon of Loligo
  3. Hogkin et al. (1952), Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo
  4. Hogkin et al. (1952), The components of membrane conductance in the giant axon of Loligo
  5. Hogkin et al. (1952), The dual effect of membrane potential on sodium conductance in the giant axon of Loligo
  6. Hogkin et al. (1952), A quatitative description of membrane current and its application to conduction and excitation in nerve
  7. Huxley (2002), From overshoot to voltage clamp
  8. Squid and giant nerve fiber videos


Jan 13: Methods 1

Part 1. Introduction to electrophysiological techniques (Thanos)
Part 2. Optogenetics

  1. (A) Adamantidis et al. (2007), Neural substrates of awakening probed with optogenetic control of hypocretin neurons
  2. (B) Cardin et al. (2009), Driving fast-spiking cells induces gamma rhythm and controls sensory responses

Jan 20: Methods 2

Part 1. Guest lecture, Laurent Moreaux
Part 2.
  1. (A) Yaksi & Friedrich (2006), Reconstruction of firing rate changes across neuronal populations by temporally deconvolved Ca2+ imaging
  2. (B) Bradley et al. (2009), Submillisecond optical reporting of membrane potential in situ using a neuronal tracer dye


Jan 27: Spike Time Dependent Plasticity

  1. (A) Markram et al. (1997), Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
  2. (B) Cassenaer & Laurent. (2007), Hebbian STDP in mushroom bodies facilitates the synchronous flow of olfactory information in locusts
  3. (C) Lubenov & Siapas. (2008), Decoupling through synchrony in neuronal circuits with propagation delays


Feb 3:Brain maps

  1. (A) Luo and Flanagan (2007), Development of Continuous and Discrete Neural Maps
  2. (B) Kohonen and Hari (1999), Where the abstract feature maps of the brain might come from
  3. (C) Durbin and Mitchison (1990), A dimension reduction framework for understanding cortical maps


Feb 10: Maps of Space

  1. (A)Fyhn et al. (2004), Spatial representation in the entorhinal cortex
    [supplementary material]
  2. (B) Hafting et al. (2005), Microstructure of a spatial map in the entorhinal cortex
    [supplementary material 1] [2] [3] [4] [5] [6] [7] [8] [9] [10]
  3. (C) Burgess et al. (2007), An Oscillatory Interference Model of Grid Cell Firing


Feb 17: REM Sleep

  1. (A) Crick and Mitchison (1983), The function of dream sleep
  2. (B) Siegel (2001), The REM Sleep-Memory Consolidation Hypothesis
  3. (C) Louie and Wilson (2001), Temporally Structured Replay of Awake Hippocampal Ensemble Activity during Rapid Eye Movement Sleep


Feb 24: Cerebral Cortex

Part 1. Guest lecture by Paul Rhodes (Evolved Machines)
Part 2.

  1. (A) Ulinski, "The Cerebral Cortex of Reptiles"
  2. (B) Reiner & Northcutt, "Succinic Dehydrogenase Histochemistry Reveals the Location of the Putative Primary Visual and Auditory Areas within the Dorsal VentricularRidge of Sphenodon punctatus"
  3. (C) Literature search and will present and lead discussion on: (1) Did the 6-layer neocortex evolve from the 3-layer pallium? (2) What functional advantages might have driven evolution from 3 to 6-layer cortex?


Mar 3: Neural Oscillations

  1. (A) Ermentrout and Kleinfeld (2001), Traveling Electrical Waves in Cortex: Insights from Phase Dynamics and Speculation on a Computational Role
  2. (B) Lubenov and Siapas (2009), Hippocampal Theta Oscillations are Travelling Waves
  3. (C) Watt et al. (2009), Traveling Waves in Developing Cerebellar Cortex Mediated by Asymmetrical Purkinje Cell Connectivity


Mar 10: Final Project

Group A Alice, Jean Luc, Say Tar, Marissa, Niranjan
Group B Russell, Ned, Britton, Rell
Group C Andrew, Yunji, Boris, Alma, Rod


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