Proteome Exploration Laboratory

Shu-ou Shan, PI
Spiros Garbis, Director

The Proteome Exploration Laboratory provides both scientific and technical expertise and state-of-the-art high performance and ultrahigh performance liquid chromatography and tandem mass spectrometric instrumentation.

The lab is currently equipped with an Agilent 1100 MSD instrument, two Thermo EASY-nLC Orbitrap instruments (Classic and Elite), and an Thermo EASY-nLC LTQFT linear ion trap with electron capture dissociation (ECD) and infrared multiple photon dissociation (IRMPD) capabilities and an AB Sciex nanoLC QTRAP. Ancillary instrumentation includes a Nanomate direct infusion device, additional HPLC systems, capillary puller etc. Our bioinformatics suite contains a Mascot server, MaxQuant, the TransProteomics Pipeline, Scaffold, Sequest, ROCCIT and other in-house developed software tools that are constantly being developed.

A major research focus within the laboratory is method development for comparative quantitative proteome analysis, including the comprehensive analysis of posttranslational modifications.

We collaborate with California Institute of Technology scientists from various backgrounds. By nature, the level of collaboration varies from project to project. To achieve best results, we encourage investigators to contact us before a project is started.

For more information, visit our website: Proteome Exploration Laboratory


Dr. Spiros Garbis, Director
Room 211 - Beckman Institute
Mail Code 139-74
Tel: (626) 395-2339

Prof. Shu-ou Shan, PI
Room 109 - Braun Lab
Mail Code 147-75
Tel: (626) 395-3879

Dr. Annie Moradian
Room 224 - Beckman Institute
Mail Code 139-74
Tel: (626) 395-2890
Dr. Michael Sweredoski
Room 201 - Beckman Institute
Mail Code 139-74
Tel: (626) 395-2792