Vijay S Chickarmane
External Affiliate - Caltech
Research Specialist - Howard Hughes Medical Institute
Division of Biology,
California Institute of Technology
Ph: (626)-395-8438, (626)-395-8937
I am interested in applying quantitative methods to understanding biological processes in plants and animals. These methods use non-linear dynamics, stochastic processes, optimization and data analysis to model signaling and genetic networks, growth and proliferation of multicellular tissues. Some of the current topics I am pursuing are,
· Computational approaches to studying plant development. Development of mathematical models and validation based on confocal microscopy and gene expression data to study: Perception of hormones (cytokinin) by plant two-component signaling networks, Homeostasis of stem cell numbers in the shoot apical meristem, Regeneration of shoots/roots due to relative hormonal levels (auxin/cytokinin), Patterning of giant cells in the sepal due to endo-reduplication (multiple copies of DNA).
· Transcriptional dynamics of hematopoietic and embryonic stem cells. Development of mathematical models based upon ChIP-chip and microarray data to understand the transcriptional dynamics of stem cells, with a view to understanding stem cell commitment, and how differentiated cells are re-programmed to become stem cells. Understanding the role of stochastic fluctuations in stem cell lineage determination.