Cell Type Specific Log10 QPCR Expression Values

SynonymCell TypeQPCR ExpressionNormalized ToData From
IL7RaCD4-0.66bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7RaCD4-0.92bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7RaCD4_24--1.28bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7RaCD4_69--0.96bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7RaCD8-1.01bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7RaCD8-1.07bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7RaCD8_24--1.48bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7RaCD8_69--1.32bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7RaDN1-1.72bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7RaDN1-2.2bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7RaDN2-0.89bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7RaDN2-0.92bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7RaDN2-0.7bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7RaDN2a-0.85bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7RaDN2a-0.96bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7RaDN3a-0.77bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7RaDN3a-0.92bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7RaDN3a-0.82bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7RaDN3a-0.74bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7RaDN3b-1.1bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7RaDN3b-1.29bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7RaDN3b-1.15bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7RaDN3b-0.89bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7RaDP-1.92bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7RaDP69--1.42bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7RaDP69--1.96bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7RaGDT-1.29bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7RaGDT-1.14bActinIntrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)

Effect of Key Gene Perturbations

SynonymPerturbationQPCR ExpressionRelative ToData From
IL7RaBM-0.9ThymusGATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
IL7RaMast-0.23ThymusGATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
IL7RaFthymus-0.46ThymusGATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
IL7RaLZ_DL0LZ,DLNotch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
IL7RaLZ_noDL-0.15LZ,DLNotch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
IL7RaLZ_DL0LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
IL7RaG3_DL-0.48LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
IL7RaKRRm_DL-0.3LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
IL7RaLZ_noDL-0.15LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
IL7RaG3_noDL -0.54LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
IL7RaKRRm_noDL-0.62LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
.
IL7RaPrmtv_LZ-0.2Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7RaPrmtv_LZ-0.19Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7RaPrmtv_PU1-0.04Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7RaPrmtv_PU1-0.67Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7RaProT_LZ0Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7RaProT_LZ0Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7RaProT_LZ0Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7RaProT_PU1-0.32Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7RaProT_PU1-0.51Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7RaProT_PU1-0.14Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7RaPreT_LZ-0.04Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7RaPreT_LZ-0.32Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7RaPreT_LZ-0.13Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7RaPreT_PU1-0.54Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7RaPreT_PU1-0.31Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7RaPreT_PU1-0.1Pro-T,LZPU.1 Effects per stage data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream NodeInteraction TypeTarget NodeLiterature Evidence
GATA-3REPRESSESIL-7RAlphaTaghon, Yui, Rothenberg 2007 Nat. Immunol.
PU1 activityPROMOTESIL-7RAlphaDeKoter, R. P.et al.: Singh Immunity. 2002 Feb;16(2):297-309.
pre-TCR signalREPRESSESIL-7RAlphaTaghon et al 2006 Immunity
High-level GATA-3REPRESSESIL-7RAlphaTaghon, Yui, Rothenberg 2007 Nat. Immunol.; Hernandez-Hoyos et al. 2003 Immunity; Anderson, M. K. et al 2002 Devel. Biol.
PU1 activityREPRESSESIL-7RAlphaFranco et al PNAS 2006
IL-7RAlphaPROMOTESIL-7.IL-7R by definition