Cell Type Specific Log10 QPCR Expression Values

Synonym	Cell Type	QPCR Expression	Normalized To	Data From
IL7Ra	CD4	-0.66	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7Ra	CD4	-0.92	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7Ra	CD4_24-	-1.28	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7Ra	CD4_69-	-0.96	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7Ra	CD8	-1.01	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7Ra	CD8	-1.07	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7Ra	CD8_24-	-1.48	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7Ra	CD8_69-	-1.32	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7Ra	DN1	-1.72	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7Ra	DN1	-2.2	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7Ra	DN2	-0.89	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7Ra	DN2	-0.92	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7Ra	DN2	-0.7	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7Ra	DN2a	-0.85	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7Ra	DN2a	-0.96	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7Ra	DN3a	-0.77	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7Ra	DN3a	-0.92	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7Ra	DN3a	-0.82	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7Ra	DN3a	-0.74	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7Ra	DN3b	-1.1	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7Ra	DN3b	-1.29	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7Ra	DN3b	-1.15	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7Ra	DN3b	-0.89	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7Ra	DP	-1.92	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7Ra	DP69-	-1.42	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7Ra	DP69-	-1.96	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
.
IL7Ra	GDT	-1.29	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)
IL7Ra	GDT	-1.14	bActin	Intrathymic T Cell Precursors vs. Myeloid Progenitors (Rothenberg, Moore, and Yui 2008, Nat. Rev. Immunology)

Effect of Key Gene Perturbations

Synonym	Perturbation	QPCR Expression	Relative To	Data From
IL7Ra	BM	-0.9	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
IL7Ra	Mast	-0.23	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
IL7Ra	Fthymus	-0.46	Thymus	GATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
IL7Ra	LZ_DL	0	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
IL7Ra	LZ_noDL	-0.15	LZ,DL	Notch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
IL7Ra	LZ_DL	0	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
IL7Ra	G3_DL	-0.48	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
IL7Ra	KRRm_DL	-0.3	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
IL7Ra	LZ_noDL	-0.15	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
IL7Ra	G3_noDL	-0.54	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
IL7Ra	KRRm_noDL	-0.62	LZ,DL	Over Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
.
IL7Ra	Prmtv_LZ	-0.2	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7Ra	Prmtv_LZ	-0.19	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7Ra	Prmtv_PU1	-0.04	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7Ra	Prmtv_PU1	-0.67	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7Ra	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7Ra	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7Ra	ProT_LZ	0	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7Ra	ProT_PU1	-0.32	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7Ra	ProT_PU1	-0.51	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7Ra	ProT_PU1	-0.14	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7Ra	PreT_LZ	-0.04	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7Ra	PreT_LZ	-0.32	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7Ra	PreT_LZ	-0.13	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7Ra	PreT_PU1	-0.54	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7Ra	PreT_PU1	-0.31	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)
IL7Ra	PreT_PU1	-0.1	Pro-T,LZ	PU.1 Effects per stage data (Franco et al. 2006 PNAS)

Evidence for Interactions

Upstream Node	Interaction Type	Target Node	Literature Evidence
GATA-3	REPRESSES	IL-7RAlpha	Taghon, Yui, Rothenberg 2007 Nat. Immunol.
PU1 activity	PROMOTES	IL-7RAlpha	DeKoter, R. P.et al.: Singh Immunity. 2002 Feb;16(2):297-309.
pre-TCR signal	REPRESSES	IL-7RAlpha	Taghon et al 2006 Immunity
High-level GATA-3	REPRESSES	IL-7RAlpha	Taghon, Yui, Rothenberg 2007 Nat. Immunol.; Hernandez-Hoyos et al. 2003 Immunity; Anderson, M. K. et al 2002 Devel. Biol.
PU1 activity	REPRESSES	IL-7RAlpha	Franco et al PNAS 2006
IL-7RAlpha	PROMOTES	IL-7.IL-7R	by definition