Effect of Key Gene Perturbations

SynonymPerturbationQPCR ExpressionRelative ToData From
EBFBM1.81ThymusGATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
EBFMast0.24ThymusGATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
EBFFthymus1.51ThymusGATA-3 Expression, Other Tissues (Taghon et al. 2007 Nat. Immunol)
.
EBFLZ_DL0LZ,DLNotch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
EBFLZ_noDL0.18LZ,DLNotch-Delta interaction data (Taghon et al. 2007 Nat. Immunol)
.
EBFLZ_DL0LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
EBFG3_DL0.06LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
EBFKRRm_DL-0.11LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
EBFLZ_noDL0.18LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
EBFG3_noDL -0.15LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)
EBFKRRm_noDL0.02LZ,DLOver Expressed GATA-3 (Taghon et al. 2007 Nat. Immunol)

Evidence for Interactions

Upstream NodeInteraction TypeTarget NodeLiterature Evidence
Pax5PROMOTESEBFRoessler, S.,et al.: Grosschedl, Mol Cell Biol. 2007 Jan;27(2):579-94
E2A.E2APROMOTESEBFHagman, J., & Lukin, K. Curr Opin Immunol. 2006 Apr;18(2):127-34
Notch.CSLREPRESSESEBFTaghon et al. 2005 Genes Dev; only demonstrated before EBF upregulation (see Smith, E.M.et al.: Sigvardsson, Blood. 2005 Sep 15;106(6):1995-2001 for alt. mechanism)
IL7R.STAT signalPROMOTESEBFRoessler, S.,et al.: Grosschedl, Mol Cell Biol. 2007 Jan;27(2):579-94
EBFPROMOTESEBF antagonized by Notch signaling (Net EBF)Bubble = net EBF escaping Notch inhibition