My lab is developing tools for carrying out three-dimensional electrophysiological measurements
on cubic millimeter scale regions, with single cell and spike time precision. We have built and
tested the first generation of high-density microelectrodes consisting of dual-side and multilayer
arrays. We have employed electron-beam lithography to construct nanoscale metallic
interconnects as a means of minimizing tissue damage during probe insertion. Currently we are
involved in an effort to scale up the complexity of our 3D neural probes to accommodate over 100
channels, and we eventually envision devices containing up to 1000 channels.

We are grateful for the generous support of the Broad Foundations in funding this work under the
Broad Fellowship Program in Brain Circuitry.