Welcome to Pine lab at Caltech, led by Prof Jerry Pine
We are interested in learning, memory, and synaptic plasticity in cultured neural networks. Professor Jerry Pine and his collaborators have developed a number of new technologies for studying neural systems. Examples include an x-ray microscope for living cells, multi-electrode cell culture chambers, fiber-optic photodiode arrays and high-speed CCD cameras for imaging of neural activity, and silicon probes for long-term interfacing of neural tissue with external electronics.
Currently, in collaboration with Prof. Yu-Chong Tai of Caltech's Electrical Engineering department, we are developing a "neurochip." The neurochip is a MEMS device that will support long-term growth of cultured neural networks (embryonic rat hippocampal cells), enabling simultaneous recording and selective stimulation of networked neurons . It will provide an unprecedented ability to monitor and influence the synaptic activity of a small network of neurons, and to discover the effects of neural activity on synaptic plasticity.
Another angle of attack involves the use of a multi-electrode array (MEA) to study the properties of dissociated, relatively large-scale cultures of cortical neurons. With these cortical neuron-MEA cultures, the influence of electrical stimulation and the resulting network activity on the formation, maintenance and modification of connections can be examined and elucidated.
Questions? Comments? send mail to erickson at caltech dot edu
This page last updated on 01/11/2006