Recent Publications

Koshnan A, Ko J, Tescu S, Brundin P, Patterson PH (2008). IkB kinase complex regulates DNA damage-induced cleavage of huntingtin protein. Submitted.

Khoshnan A, Southwell A, Bugg CW, Ko J, Patterson PH (2008) Recombinant antibodies as molecular tools and potential therapeutics for Huntington's disease. In, "New Therapeutics in Huntington's Disease", Eds. RE Hughes and DC Lo. Taylor & Francis Group.

Patterson PH, Xu W, Smith SEP, Deverman BE (2008) Maternal immune activation, cytokines and autism. In "Autism: Current Theories and Evidence", ed. Zimmerman, AW, Humana Press, Totowa, NJ.

Shi L, Smith SEP, Malkova N, Tse D, Patterson PH (2008). Activation of the maternal immune response alters cerebellar development in the offspring. Brain Behav Immun, in press.

Smith SEP, Patterson PH. (2008) Immune challenge, neurodevelopment and behavior. In “The Neuroimmunological Basis of Behavior and Mental Disorders”, eds. Siegel A and Zalcman SS, Springer, Norwell, MA.

Southwell A, Khoshnan A, Dunn D, Bugg C, Lo D, Patterson PH (2008) Intrabodies binding the proline-rich domain of mutant huntingtin increase its turnover and reduce neurotoxicity. J Neurosci, in press.

Bauer S, Kerr B, Patterson PH (2007) The neuropoietic cytokine family in development, plasticity, disease and injury. Nature Rev Neurosci 8:221-32.

Gardberg AS, Dice LT, Ou S, Rich RL, Helmbrecht E, Ko J, Wetzel R, Myszka DG, Patterson PH, Dealwis C (2007) Molecular basis for passive immunotherapy of Alzheimer's disease. Proc Natl Acad Sci USA 104:15659-64.

Greger B, Kateb B, Gruen P, Patterson PH (2007) A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals. J Neurosci Meth 163:321-5.

Patterson, PH (2007) Maternal effects on schizophrenia risk. Science 318:576-7.

Smith SEP, Li J, Garbett K, Mirnics K, Patterson PH (2007) Maternal immune activation alters fetal brain development through interleukin-6. J Neurosci 27:10695-702.

Bauer S and Patterson PH (2006) Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain. J Neurosci 26:12089-99.

Holmberg KH and Patterson PH (2006) Leukemia inhibitory factor is a key regulator of astrocytic, microglial and neuronal responses to seizure. Brain Res1075:26-35.

Montgomery JP, Patterson PH (2006) Behavioral stress and tumor progression. Anticancer Res 26:1189-92.

Patterson PH (2006) Modeling features of autism in animals, In “Understanding Autism: From Basic Neuroscience to Treatment”, Moldin, SO and Rubenstein, JLR, Eds., Taylor & Francis, Boca Raton, FL, pp. 277-302.

Patterson PH (2006) Pregnancy, immunity, schizophrenia and autism. Engineering and Science 69:10-21.

Bauer, S and Patterson, PH (2005) The cell cycle-apoptosis connection revisited in the adult brain, J. Cell Biol. 171:641-50.

Kerr, BK and Patterson, PH (2005) Leukemia inhibitory factor (LIF) promotes oligodendrocyte survival after spinal cord injury. Glia 51:73-79.

Patterson, PH (2005) Maternal infection causes altered behavior in the offspring. In “Neuropsychiatric Disorders and Infection”, SH Fatemi ed., Taylor & Francis, London, pp. 83-90.

Patterson, PH (2005) Modeling features of autism in animals, In, “Neurobiology of Autism in the Post-Genomic Era”, Moldin, SO and Rubenstein, JLR, Eds., Taylor & Francis, Boca Raton, FL, in press.

Schmitz C, van Kooten IAJ, Hof PR, van Engeland H, Patterson PH, Steinbusch HWM (2005) Autism: Neuropathology, alterations of the GABAergic system, and animal models. Internl Rev Neurobiol 71:1-26.

Shi, L, Tu, N and Patterson, PH (2005) Maternal influenza infection is likely to alter fetal brain development indirectly: the virus is not detected in the fetus. Intl. J. Develop. Neurosci. 23: 299-305.

Berry, MF, Pirolli, TJ, Jayasankar, V, Moriine, KJ, Moise, MA, Fisher, O, Gardner, TJ, Patterson, PH and Woo, YJ (2004) Targeted overexpression of leukemia inhibitory factor to preserve myocardium in a rat model of postinfarction heart failure. J. Thoracic Cardiovasc. Surg. 128: 866-875.

Kerr, BJ and Patterson, PH (2004) Potent pro-inflammatory actions of leukemia inhibitory factor in the spinal cord of the adult mouse. Exper. Neurol. 188: 391-407.

Khoshnan, A, Ko, J, Watkin, EE, Paige, LA, Reinhart, PH and Patterson, PH (2004) Activation of the Ik-B kinase complex and NF-kB contributes to mutant huntingtin neurotoxicity. J. Neurosci. 24: 7999-8008.

Khoshnan, A, Ou, S, Ko, J and Patterson, PH (2004) Antibodies against huntingtin: Production and screening of monoclonal and single chain recombinant forms. In, “Methods in Molecular Biology”, vol. 277: Triplet Repeat Protocols, Kohwi, Y., Ed., Human Press, Totowa, NJ, pp. 87-102.

Lahav, R, Suva, M-L, Rimoldi, D, Patterson, PH and Stamenkovic, I (2004) Endothelin B inhibition triggers apoptosis and enhances angiogenesis in melanomas. Cancer Res. 64: 8945-8953.

Patterson, PH (2004) Maternal infection yields offspring with altered behavior. In, “Neuropsychiatric Disorders and Infection”, Fatemi, SH, Ed., Taylor & Francis Ltd., London, pp. 83-90.

Watanabe, Y, Hashimoto, S, Kakita, A, Takahashi, H, Ko, J, Mizuno, M, Someya, T, Patterson, PH and Nawa, H (2004) Neonatal impact of leukemia inhibitory factor on neurobehavioral development in rats. Neurosci. Res. 48: 345-353.

Armstrong, BD, Hu, Z, Abad, C, Yamamoto, M, Rodriguez, WI, Cheng, J, Tam, J, Gomariz, RP, Patterson, PH, and Waschek, J (2003) Lymphocyte regulation of neuropeptide gene expression after neuronal injury. J. Neurosci. Res. 74:240-247.

Bauer, S, Han, J, Rasika, S, Mauduit, C, Jourdan, F, Benahmed, M, Moyse, E and Patterson, PH (2003) Leukemia inhibitory factor induction is a key signal of lesion-triggered neurogenesis in the adult mouse olfactory epithelium. J. Neurosci. 23:1792-1803.

Pichel, JG, Fernandez-Moreno, C, Vicario-Abejon, C, Testillano, PS, Patterson, PH and de Pablo, F (2003) Developmental cooperation of leukemia inhibitory factor and insulin-like growth factor I in mice is tissue-specific and essential for lung maturation involving the transcription factors Sp3 and TTF-1. Mech. Develop. 120:349-361.

Shi, L, Fatemi, SH, Sidwell, RW and Patterson, PH (2003) A mouse model of mental illness: maternal influenza infection causes behavioral and pharmacological abnormalities in the offspring. J. Neurosci. 23:297-302.

Fatemi SH, Earle J, Kanodia R, Kist D, Emamian ES, Patterson PH, Shi L, Sidwell, R. (2002) Prenatal viral infection leads to pyramidal cell atrophy and macrocephaly in adulthood: implications for genesis of autism and schizophrenia. Cell Mol. Neurobiol. 22: 25-33

Khoshnan, A, Ko, J and Patterson, PH (2002) Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity. Proc. Natl. Acad. Sci. U.S.A. 99: 1002-1007.

Patterson, PH (2002) Maternal infection: Window on neuroimmune interactions in fetal brain development and mental illness. Curr. Opin. Neurobiol. 12: 115-118.

Tofaris, GK, Patterson, PH, Jessen, KR and Mirsky, R (2002) Denervated Schwann cells attract macrophages by secretion of LIF and MCPö1 in a process regulated by IL-6 and LIF. J. Neurosci., 22:6696-6703.

Jankowsky, JL and Patterson, PH (2001) The role of cytokines in seizure and its sequelae. Progr. Neurobiol. 63:125-149.

Ko, J, Ou, S and Patterson, PH (2001) New anti-huntingtin monoclonal antibodies: Implications for huntingtin conformation and its binding proteins. Brain Res. Bull. 56: 319-329.

Zhu, M, Oishi, K, Lee, SC and Patterson, PH (2001) Studies using LIF knockout mice and a LIF adenoviral vector demonstrate a key anti-inflammatory role for this cytokine in cutaneous inflammation. J. Immunol. 166: 2049-2054.

Jankowsky, JL and Patterson, PH (2000) Cytokine and growth factor involvement in long-term potentiation. Molec. Cell. Neurosci. 14: 529-543.

Jankowsky, JL, Derrick, BE and Patterson, PH (2000) Cytokine responses to hippocampal slice preparation, in vivo electrode insertion, and LTP induction. Learning and Memory 7: 400-412.

Nawa, H, Takahashi, M and Patterson, PH (2000) Cytokine and growth factor involvement in schizophrenia - support for the developmental model. Molec. Psychiat. 5: 594-603.

Sugiura, S, Lahav, R, Han, J, Kou, S-Y, Banner, LR, de Pablo, F and Patterson, PH (2000) Leukemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems and is chemotactic for macrophages in vitro. Europ. J. Neurosci. 12: 457-466.

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This page last updated August 5, 2008 by C. Patterson.