Matthew
J. Nelson
Graduate student-
Computation & Neural Systems
Department, California
Institute of Technology
Visiting graduate student-
Schall lab, Vanderbilt University
CV
nelsonmj@caltech.edu
I am a neuroscience graduate student in the
CNS
department
at Caltech, presently completing the research for my doctoral
thesis in
the
lab
of Jeffrey Schall in the Psychology Department at Vanderbilt
University. I have
also worked in the lab of Richard Andersen previously at Caltech. For
my
undergraduate education I attended the University of Michigan where I
received
a B.S.E. in Chemical Engineering as well as a B.S. in Biopsychology
with Honors.
Research Projects
My thesis will focus on improving our
understanding of how
competing saccade plans are represented in the brain and how they
develop
during the reaction time period before a subject makes an eye movement.
To study
this, we use multiple electrode recordings in the Frontal Eye Fields in
a
search-step paradigm in which a subject has to respond to an unexpected
step in
the target position of an eye movement just before an eye movement is
made. By
varying the time delay between the appearance and unexpected step of
the target,
we can systematically affect the probability of whether or not a
subject will correctly
compensate for the target step with their impending eye movement. We do
this while
simultaneously observing the activity of neurons involved in responding
to both
the initial and final target locations. I am also studying the effects
of
repeated stimuli and eye movements on consecutive trials, and
characterizing
the adverse effects that unavoidable behavioral nonstationarities and
low
frequency fluctuations have on these and other analyses within this and
other paradigms.
In previous work I have also reviewed and
experimentally
demonstrated the electrical circuit properties of metal microelectrode
recordings, and quantified distortions of recorded signals that can
occur but
may be frequently overlooked by many neurophysiologists. In my earlier
work in
the Andersen lab, I helped find a novel frame of reference that exists
for
neural activity of single units in the dorsal pre-motor cortex, which
we showed
encode all the relative positions between the eye, hand and the target
of an
impending reach movement. Other work I did in the lab demonstrated a
significant, persistent coherence between spikes and local field
potentials in
the connected brain regions of dorsal premotor cortex and the parietal
reach region.
We found this coherence is more prevalent when monkeys are freely
choosing
where to reach, as opposed to merely following instructions as to where
to
reach.
Research
Interests
I am particularly fond of interdisciplinary
approaches to
studying the brain that can be described as the intersections of
neuroscience,
cognitive psychology and other engineering fields. General research
interests
of mine include studying cognition and decision making with a
particular
emphasis on how these functions can arise from networks of interacting
single
units. More specifically, I believe understanding how stimulus-response
mappings are carried out in the human and non-human primate brain will
be
important towards that broader research goal. Finally, I am interested
in improving our understanding of how electrical voltage
and currents propagate within the brain.