Welcome to the Roukes Group
We are working to explore new physics at the nanoscale, and to apply this knowledge to realizing advanced tools for the biomedical and life sciences. Our group's current focus is on (a) next-gen methods for neuroscience enabled by very-large-scale integration of nanoelectronic and nanophotonic devices, (b) single-molecule mass spectrometry and molecular analysis enabled by arrays of nanoelectromechanical systems (NEMS), and (c) on the fundamental physics of NEMS.

The most exciting frontiers in nanoscience and nanotechnology, in our opinion, are highly cross-disciplinary and can only be explored by forging strong ties with other laboratories. We are privileged to be working with excellent collaborators around the world.

We are closely collaborating in research at the interface between neuroscience and nanoscience with the groups of Professors Thanos Siapas (Caltech), Andreas Tolias (Baylor College of Medicine), Ken Shepard (Columbia), and Andrei Faraon (Caltech). We also have long-standing collaborative interactions with the groups of Profs. Gilles Laurent and Erin Schuman, Directors of the Max Planck Institute for Brain Research, in Frankfurt, Germany, and the group of Prof. Francois Berger, M.D., Director of CEA/Clinatec in Grenoble.

We are collaborating in research on single-molecule analysis enabled by nanomechanical systems with Dr. Alexander Makarov and his team at Thermo Fisher Scientific in Bremen, as well as with the groups of Professors Selim Hanay (Bilkent U., Ankara) and Guillermo Villanueva (EPFL, Lausanne). Very-large-scale integration of NEMS pixel arrays for this work is being pursued in collaboration with CEA/LETI in Grenoble, France...

...In 2006 we formed the Alliance for Nanosystems VLSI (very-large-scale integration), a close partnership with scientists and engineers at CEA/LETI-MINATEC and CEA/LETI-CLINATEC in Grenoble, France. Together we have demonstrated the first examples of very-large-scale integration (VLSI) of nanoelectromechanical systems, and these have led to a first start-up, Analytical Pixels, based in Grenoble. Our current efforts are focused on highly-multiplexed nanosystems -- for single-molecule analysis and for complex, local, and massively-parallel neurophysiological recording, stimulation, and chemical analysis in vivo. All of our efforts are founded on approaches that are readily producible en masse to enable both large-scale fundamental explorations at the frontiers of the life sciences, and commercializable technology.

In the News

Professor Roukes delivers a Neils Bohr Lecture at the University of Copenhagen entitled "Integrated Neurophotonics: A Vision for Massively-Parallel Interrogation of Brain Activity". 11-12-14

Congratulations to Heather! Our paper "Vapor Sensing Characteristics of Nanoelectromechanical Chemical Sensors Functionalized Using Surface-Initiated Polymerization" by H.C. McCaig et al., is published in Nano Letters. 06-12-14

Congratulations to Matt! Our paper "Synchronization of two anharmonic nanomechanical oscillators" by M.H. Matheny et al., is published in Physical Review Letters. 01-10-14 Supplementary Information

Congratulations to Caryn! Our paper "Dynamic Similarity of Oscillatory Flows Induced by Nanomechanical Resonators" by E.C. Bullard et al., is published in Physical Review Letters. 01-10-14 Supplementary Information

Caltech Engineering & Science Magazine profiles local efforts and history behind the quest for brain activity mapping, and the evolution of Obama's BRAIN Initiative.  Fall 2013 Issue.

5-year MURI grant awarded for collaborative research on "Predicting and Controlling Systems of Interdependent Networks: Exploiting Interdependence for Control" 07-03-2013

Physics World identified Professor Roukes' talk at the 2013 American Physical Society March Meeting (~10,000 attendees) one of its "five best". 03-22-13

In 2011, 2012 and 2013 Professor Roukes collaborated with five other scientists to advocate for a large-scale U.S. national effort to pursue "Brain Activity Mapping". This has led to the launching of the Obama BRAIN Initiative. 2011-2013

Single-Protein Nanomechanical Mass Spectrometry-- a new technique developed over more than a decade of effort by Michael L. Roukes, Professor of Physics, Applied Physics, and Bioengineering at Caltech, and his colleagues, simplifies and miniaturizes analyses through use of very tiny nanoelectromechanical system (NEMS) resonators. Read more... 08-26-2012

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