Jay Nadeau's web page

Education : Ph.D., physics, University of Minnesota (1996)
published in Physical Review D here

  Research and Publications

A publications list is here
Postdoc: Caltech
Burroughs-Wellcome program for physics and biology, 1997-200

This is an invited talk I gave at Rush University in January, 2001
Topics are ion channel biosensors, quantum dots, and high-Q
resonators
Download Powerpoint

Currently (since 12/00): Staff scientist
Jet Propulsion Laboratory Center for Life Detection
Visiting associate, Mathematics and Physics, Caltech

(working with the NEMS group)
This is a presentation on bio-NEMS given at the first international
school on nanoscale molecular mechanics, Maui, May 2002
Download Powerpoint



Contact information: Jay L. Nadeau, JPL 183-301
4800 Oak Grove Dr. Pasadena, CA 91109
nadeau@mail2.jpl.nasa.gov
(818) 354-0522 / (818) 393-4445 (FAX)  
 

Postdoctoral Research


As a postdoc in the Lester/Davidson lab at Caltech, I used
lentivirus to label neurons and mouse brain
My CV is here          or you may download .pdf



The goal was to silence targeted neurons by increasing potassium
conductance by expressing a constitutively open K channel,
ROMK1 (for text of a talk explaining the project, go here )
or decreasing sodium conductance by suppressing Na channel
expression using NRSF  (neuron restrictive silencer factor)

                                                                                                     

Group members



Here are some results of injection of ROMK1 and NRSF
into mouse embryos

Jeremiah Kloepfer, postdoc since 4/1/02
Jeremy is working on CdSe and CdSe/ZnS quantum dots (QDs),
elucidating their photophysical properties in aqueous solutions and
investigating their use as biological labels

Diane Engler, senior technician, astrobiology
Diane is a protein chemist with several years of industrial experience.
She works on protein purification of ion channels, molecular cloning,
and fluorescent tagging of proteins.

Here are some pictures of multielectrode arrays ( MEA s) infected
with lentivirus.  Work done in collaboration with Steve Potter
of the Pine Lab .

JPL Collaborators and Co-Is

Victor White, Microdevices Laboratory (MDL)
Victor does all of the microprocessing for the Ion Channel Biosensor

Susanne Douglas, Center for Life Detection
Susanne is a biogeochemist who will perform field and laboratory work
for the Robotic Chemistry Lab.

Heny Sun, Center for Life Detection
Henry is a microbiologist involved with the Robotic Chem Lab


Current Research

Ion Channel Biosensors

In a collaboration with Dennis Dougherty of Caltech, we are making a
MEMS-based ion channel sensor

Quantum Dots for Biological Labeling


Robotic Chemistry Lab for Martian Life Detection
Starsys Research has created a flight-ready Robotic Chemistry Lab.
We are using this tool to define wet chemistry experiments for
life detection, which we will propose for future Mars missions.