Readings in Hille

Additional Required Reading

Staley K, Smith R, Schaack J, Wilcox C, Jentsch TJ. 1996. Alteration of GABA_A receptor function following gene transfer of the  CLC-2 chloride channel.  Neuron 1996 17:543-51
An introduction to viral vectors, gene therapy, and the possibility of manipulating excitability
 online article    local reprint

Pusch M, Jordt SE, Stein V, Jentsch TJ (1999).  Chloride dependence of hyperpolarization-activated chloride channel gates.  J Physiol ,515: 341-53
Analysis of gating in a Cl channel
 online article    local reprint

Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA, Harrison NL (1997).  Sites of alcohol and volatile anaesthetic action on GABA_A and glycine receptors.Nature  389:385-9
Mapping the binding site for a blocker.
 online article    local reprint

Inward Rectifier K channels

Kofuji P, Hofer M, Millen KJ, James H. Millonig JM, Davidson N, Lester HA, and Hatten ME (1996) Functional analysis of the mutant weaver GIRK2 potassium channel and rescue of weaver granule cells. Neuron 16:941-952.
Continuing the theme of pathophysiological principles in ion channel disease
 online article    local reprint

Baukrowitz T, Tucker SJ, Schulte U, Benndorf K, Ruppersberg JP, Fakler B (1998).  Inward rectification in KATP channels: a pH switch in the pore.  EMBO J 18:847-53
Analysis of K channel block by iunteacellular cations
   online article  local reprint

Makhina EN, and Nichols CG (1998) Independent trafficking of K_ATP channel subunits to the plasma membrane. J Biol Chem 273:3369-74.
This channel is a heteromultimer of a Kir family member and an ABC transporter member!
 online article    local reprint