Caltech Bi 211 Fall 1999

Revised 11/9/99
Course announcement
Tentative Schedule
Requirements
Session 8
Thursday
11/16
7:00 PM
234 Kerckhoff
Gating by Intracellular Messengers 
Yen Bui
Wen Chen
Jack Horne 

Readings in Hille

Chapter  8, pp220-35

Additional Required Reading

1. Cyclic nucleotide-gated channels
Sunderman, E. R. and W. N. Zagotta 1999. Mechanism of allosteric modulation of rod cyclic nucleotide-gated channels. J Gen Physiol. 113:601-20.
 Paper  Local copy

Sunderman, E. R. and W. N. Zagotta 1999. Sequence of events underlying the allosteric transition of rod cyclic nucleotide-gated channels. J Gen Physiol. 113:621-40.2.
 Paper  Local copy

2.  The IP3  and ryanodine receptors
Michikawa, T., J. Hirota, S. Kawano, M. Hiraoka, M. Yamada, T. Furuichi and K. Mikoshiba 1999. Calmodulin mediates calcium-dependent inactivation of the cerebellar type 1 inositol 1,4,5-trisphosphate receptor. Neuron. 23:799-808.
Introducing bilayer measurments on the channels of intracellular organelles
 Paper   Local copy

L. M. John, Lechleiter, J. D.,  and P. Camacho 1998. Differential modulation of SERCA2 isoforms by calreticulin. J. Cell Biol. 142:963-973
 PaperLocal copy
Intracellular Ca2+ often appears in propagated waves.

3.  I(crac), capacitive Ca entry
Niemeyer BA, Suzuki E, Scott K, Jalink K, and Zuker CS (1996) The Drosophila light-activated conductance is composed of the two channels TRP and TRPL. Cell 85:651-9.
 Paper  Local copy

Xu, X. Z., H. S. Li, W. B. Guggino and C. Montell 1997. Coassembly of TRP and TRPL produces a distinct store-operated conductance. Cell. 89:1155-64.
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The concept of capactitative Ca2+ entry that refills intracellular stores.

Chyb, S., P. Raghu and R. C. Hardie 1999. Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. Nature. 397:255-9.
 Abstract
 

Reviews

Takahashi, A., P. Camacho, J. D. Lechleiter and B. Herman 1999. Measurement of intracellular calcium. Physiol Rev. 79:1089-1125.
 Paper

Lewis RS.  Store-operated calcium channels.  Adv Second Messenger Phosphoprotein Res 1999;33:279-307

Li J, Zagotta WN, and Lester HA (1997) Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation. Q Rev Biophys 30:177-93.

Mikoshiba K (1997) The InsP3 receptor and intracellular Ca2+ signaling. Curr Opin Neurobiol 7:339-45.

Berridge, M. J. 1998. Neuronal calcium signaling. Neuron. 21:13-26.
 Paper