Caltech Bi 211 Fall 1999

Revised 9/28/99
Course announcement
Tentative Schedule
Requirements

Session 4
Tuesday
10/19
7:00 PM

Glutamate and P2X Receptor
Superfamilies

1. Karli Watson
2. W. Bryan Smith

Readings in Hille

Chapter 15

Additional Required Readings

Zuo, J., P. L. De Jager, K. A. Takahashi, W. Jiang, D. J. Linden and N. Heintz 1997. Neurodegeneration in Lurcher mice caused by mutation in d2 glutamate receptor gene. Nature. 388:769-773.
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Continuing the theme of inherited neuroscience diseases caused by excitability proteins: a model for excitoxicity and a useful proof of function.

Armstrong, N., Y. Sun, G. Q. Chen and E. Gouaux 1998. Structure of a glutamate-receptor ligand-binding core in complex with kainate. Nature. 395:913-7.
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Our introduction to the crytstallogrpahic analysis of ion channels.

Washburn, M. S., M. Numberger, S. Zhang and R. Dingledine 1997. Differential dependence on GluR2 expression of three characteristic features of AMPA receptors. J Neurosci. 17:9393-406.
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A good example of the problems and opportunities in correlating rectification, block, and Ca permeability between real neurons and heterologous expression systems.

Kupper, J., P. Ascher and J. Neyton 1998. Internal Mg2+ block of recombinant NMDA channels mutated within the selectivity filter and expressed in Xenopus oocytes. J Physiol (Lond). 507:1-12.
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The state of the art in biophysical analysis of Mg bloakce at NMDA receptors

Khakh, B. S., X. R. Bao, C. Labarca and H. A. Lester 1999. Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nature Neurosci. 2:322-330.
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Lewis, C., S. Neidhart, C. Holy, R. A. North, G. Buell and A. Surprenant 1995. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP- gated currents in sensory neurons. Nature. 377:432-5.
More on the problem of knowing when one has the correct subunit
(Reprints available from HAL)