Caltech Bi 211 Fall 1999

Revised 11/28/99
Course announcement
Tentative Schedule
Requirements

Session 10
Tuesday
11/30/99
7:00 PM

Mechanosensitive Channels

George Shaovalov
Andy Yeh

Readings in Hille

None

Additional Required Reading

MscL
Sukharev SI, Blount P, Martinac B, Blattner FR, Kung C. A. 1994. Llarge-conductance mechanosensitive channel in E. coli encoded by mscL alone. Nature 368:265-8.
Available on the filing cabinet outside 328 Kerckhoff

Sukharev SI, Sigurdson WJ, Kung C, Sachs F. 1999. Energetic and spatial parameters for gating of the bacterial large conductance mechanosensitive channel, MscL. J Gen Physiol 113:525-40.
online paper local reprint

Chang G, Spencer RH, Lee AT, Barclay MT, Rees DC. 1998. Structure of the
MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive
ion channel. Science 282:2220-6.
online paper local reprint

Hair Cells
Corey DP, Hudspeth AJ. 1983. Analysis of the microphonic potential of the bullfrog's sacculus. J Neurosci 3:942-961
Available on the filing cabinet outside 328 Kerckhoff

Corey DP, Hudspeth AJ. 1983. Kinetics of the receptor current in bullfrog saccular hair cells. J Neurosci 3:962-976
Available on the filing cabinet outside 328 Kerckhoff