Publications

2015
  • Vectored antibody gene delivery mediates long-term contraception. Juan Li, Alejandra I. Olvera,Omar S. Akbari, Annie Moradian, Michael J. Sweredoski, Sonja Hess, and Bruce A. Hay. Current Biology 25, R811–R826, October 5, 2015.
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2014
  • Identification of germline transcriptional regulatory elements in Aedes aegypti. Akbari OS, Papathanos PA, Sandler JE, Kennedy K, Hay BA. Sci Rep. 2014 Feb 4;4:3954.
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2013
  • Transcriptome profiling of nasonia vitripennis testis reveals novel transcripts expressed from the selfish b chromosome, paternal sex ratio. Akbari OS, Antoshechkin I, Hay BA, Ferree PM. G3 (Bethesda). 2013; 3: 1597–1605.
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  • The Developmental Transcriptome of the Mosquito Aedes aegypti, an invasive species and major arbovirus vector. Akbari OS, Antoshechkin I, Amrhein H, Williams B, Diloreto R, Sandler J, Hay BA. G3 (Bethesda) 2013; 3: 1493–1509.
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  • A synthetic gene drive system for local, reversible modification and suppression of insect populations. Akbari OS, Matzen KD, Marshall JM, Huang H, Ward CM, Hay BA. Curr Biol. 2013 Apr 22; 23(8):671-7.
    • Comment: Insect biotechnology: controllable replacement of disease vectors. Wimmer EA. Curr Biol. 2013 May 20;23(10):R453-6.
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Comment
2012
  • Novel Synthetic Medea Selfish Genetic Elements Drive Population Replacement in Drosophila; a Theoretical Exploration of Medea-Dependent Population Suppression. Akbari OS, Chen CH, Marshall JM, Huang H, Antoshechkin I, Hay BA. ACS Synth Biol. 2012

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  • General principles of single-construct chromosomal gene drive. Marshall JM, Hay BA. Evolution. 2012 Jul; 66(7):2150-66
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  • Molecular Insights into Parkinson's Disease. Rochet JC, Hay BA, Guo M. Progress in Molecular Biology and Translational Science. 2012;107:125-88.

  • Confinement of gene drive systems to local populations: A comparative analysis. Marshall JM, Hay BA. J Theor Biol. 2012 Feb 7;294:153-71.
2011
  • The toxin and antidote puzzle: New ways to control insect pest populations through manipulating inheritance. Marshall JM. Bioeng Bugs. 2011 Sep 1;2(5). (Funded by a Directors Pioneer Award to Bruce Hay)

  • Inverse Medea as a novel gene drive system for local population replacement: a theoretical analysis. Marshall JM, Hay BA. J Hered. 2011 May-Jun;102(3):336-41.

  • Medea selfish genetic elements as tools for altering traits of wild populations: a theoretical analysis. Ward CM, Su JT, Huang Y, Lloyd AL, Gould F, Hay BA. Evolution. 2011 Apr;65(4):1149-62.

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  • Semele: a killer-male, rescue-female system for suppression and replacement of insect disease vector populations. Marshall JM, Pittman GW, Buchman AB, Hay BA. Genetics. 2011 Feb;187(2):535-51.

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  • Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. Lee G, Wang Z, Sehgal R, Chen CH, Kikuno K, Hay B, Park JH. J Comp Neurol. 2011 Jan 1;519(1):34-48.
2010
  • Inactivation of both foxo and reaper promotes long-term adult neurogenesis in Drosophila. Siegrist SE, Haque NS, Chen CH, Hay BA, Hariharan IK. Curr Biol. 2010 Apr 13;20(7):643-8.

  • Engineering the genomes of wild insect populations: Challenges, and opportunities provided by synthetic Medea selfish genetic elements. Hay BA, Chen CH, Ward CM, Huang H, Su JT, Guo M. J Insect Physiol. 2010 Oct;56(10):1402-13.
2009
  • The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila. Ribaya JP, Ranmuthu M, Copeland J, Boyarskiy S, Blair AP, Hay B, Laski FA. Dev Biol. 2009 May 1;329(1):25-35.
2008
  • Sathyanarayanan S, Zheng X, Kumar S, Chen CH, Chen D, Hay B, Sehgal A. (2008) Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen. Genes Dev. 22(11):1522-33.
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  • Differential requirements for the Pax6(5a) genes eyegone and twin of eyegone during eye development in Drosophila. Yao JG, Weasner BM, Wang LH, Jang CC, Weasner B, Tang CY, Salzer CL, Chen CH, Hay B, Sun YH, Kumar JP. Dev Biol. 2008 Mar 15;315(2):535-51.
2007
  • Shcherbata H.R., Ward E.J., Fischer K.A.,Yu J-A,Reynolds S.H.,
    Chen CH, Xu P,Hay B.A., Ruohola-Baker H. Stage-Specific Differences in the Requirements for Germline Stem Cell Maintenance in the Drosophila Ovary. Cell Stem Cell 1:698–709

  • Copeland JM, Bosdet I, Freeman JD, Guo M, Gorski SM, Hay BA. echinus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with homology to ubiquitin-specific proteases. BMC Dev Biol. 2007 Jul 5;7:82.

  • Chen CH,Huang H,Ward CM,Su JT,Schaeffer LV,Guo M,Hay BA. (2007) A Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila. Science.  2007 Apr 27;316(5824):597-600.
          Comments:


Supplement

  •  Huh JR, Foe I, Muro I, Chen CH, Seol JH, Yoo SJ, Guo M, Park JM, Hay BA. (2007) The Drosophila IAP DIAP2 is dispensable for cell survival, required for the innate immune response to Gram-negative bacterial infection, and can be negatively regulated by the Reaper/Hid/Grim family of IAP-binding apoptosis inducers. J Biol Chem. 282(3):2056-68
2006
  • Chen CH, Guo M, Hay BA. (2006) Identifying microRNA regulators of cell death in Drosophila. Methods Mol Biol. 342:229-40.

  • Muro I, Berry DL, Huh JR, Chen CH, Huang H, Yoo SJ, Guo M, Baehrecke EH, Hay BA. (2006) The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process. Development. 133(17):3305-15.

  • Hay BA, Guo M. (2006) Caspase-dependent cell death in Drosophila. Annu Rev Cell Dev Biol. 22:623-50.

  • Clark IE, Dodson MW, Jiang C, Cao JH, Huh JR, Seol JH, Yoo SJ, Hay BA, Guo M. (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature. 441(7097):1162-6.

  • Yan N, Huh JR, Schirf V, Demeler B, Hay BA, Shi Y.  (2006)  Structure and activation mechanism of the Drosophila initiator caspase Dronc. J Biol Chem. 281(13):8667-74.
2004
  • Hay, B.A., Huh, J.R., and Guo, M. (2004). The genetics of cell death: approaches, insights and opportunities in Drosophila. Nature Reviews Genetics. 5, 911-922.

  • Xu, P., Guo, M., and Hay, B.A. (2004). MicroRNAs and the regulation of cell death. Trends in Genetics. 20, 618-624.

  • Huh JR, Guo M and Hay BA. (2004). "Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Drone in a nonapoptotic role." Curr Biol. 14(14). pp 1262-6

  • Huh, J. R., Vernooy, S. Y., Yu, H., Yan, N., Shi, Y., Guo, M., and Hay, B. A. (2004). Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLOS Biology 2, 43-53.
2003
  • Chai, J., Yan, N., Huh, J.R., Wu, J-W., Li, W., Hay, B.A., and Shi, Y. (2003). Molecular mechanism of Reaper/Grim/Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination. Nature Structural Biology, (10, 892-898).

  • Hay, B.A., and Guo, M. (2003). Coupling cell growth, proliferation and death: Hippo weighs in. Developmental Cell (5, 361-363).

  • Guo, M., Hong, E.J., Fernandez, J., Zipursky, S.L., and Hay, B.A. (2003). A reporter for Amyloid precursor protein ?-secretase in Drosophila. Human Molecular Genetics (12, 2669-2678).

  • Xu, P., Vernooy, S.Y., Guo, M., and Hay, B.A. (2003). The Drosophila microRNA mir-14 suppresses cell death and is required for normal fat metabolism. Current Biology. 13, 790-795.

  • Olson, M.R., Holley, C.L., Yoo, S.J., Huh, J.R., Hay, B.A., and Kornbluth, S. (2003). Reaper is regulated by IAP-mediated ubiquitination. J. Biol. Chem 278, 4028-4034.
2002
  • Muro, I., Hay, B. A. and Clem, R. J. (2002). The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC. J. Biol. Chem. 277, 49644-49650.

  • Huh, J. R. and Hay, B. A. (2002) Sculptures of a fly's head. Nature, 418, 926-927.

  • Dorstyn, L., Read, S., Cakouros, D., Huh, J. R., Hay, B. A., and Kumar, S. (2002). The role of cytochrome c in caspase activation in Drosophila melanogaster cells. J. Cell Biol. 156, 1089-1098.

  • Yoo, S. J., Huh, J. R., Muro, I., Yu, H., Wang, L., Wang, S. L., Feldman, R. M. R., Clem, R. J., Muller, H.-A. J., and Hay, B. A. (2002). Apoptosis inducers Hid, Rpr and Grim negatively regulate levels of the caspase inhibitor DIAP1 by distinct mechanisms. Nature Cell Biol. 4, 416-424.

Supplement

  • Sun-Yun Yu, Yoo, S.J., Yang, L., Zapata, C., Srinivasan, A.,Hay, B. A. and Baker, N.E. (2002). Apathway of signals regulating effector and initiator caspases in the developing Drosophila eye. Development. 129, 3269-3278.

  • Vernooy, S. Y., Chow, V., Su, J., Verbrugghe, K., Yang, J., Cole, S., Olson, M. R., and Hay, B. A. (2002) Drosophila Bruce can potently supress Rpr- and Grim-, but not Hid-dependent cell death. Current Biol. 12, 1164-1168.

Supplement
2001
  • Wu, J-W, Cocina, A.E., Chai, J., Hay, B. A., and Shi, Y. (2001). Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides. Mol. Cell 8, 95-104.
2000
  • Hawkins, C. J., Wang, S. L., and Hay, B. A. (2000). Monitoring the activity of caspases and their regulators in yeast. Methods in Enzymology 322, 162-174.

  • Hay, B. A. (2000) Understanding IAP function and regulation: a view from Drosophila. Cell Death and Differentiation 7, 1045-1056.

  • Vernooy, S. Y., Griffin, E. E., Ghaboosi, N., Copeland J., and Hay, B. A. (2000). Cell death in Drosophila: Conservation of mechanism and unique insights. J. Cell Biol. 150, F69-F75.

  • Hawkins, C. J., Yoo, S. J., Peterson, E. P., Wang, S. L., Vernooy, S. Y., and Hay, B. A. (2000). The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID and GRIM. J. Biol. Chem. 275, 27084-27093.

  • Rubin, G. M., et al., (2000). Comparative genomics of the eukaryotes. Science, 287, 2204-2215.
1999
  • Guo, M, and Hay, B. A. (1999). Emerging links between cell proliferation and apoptosis. Current Opinion in Cell Biology, 11, 745-752.

  • Wang, S.L., Hawkins, C. J., Yoo, S. J., Muller, H.-A. J., and Hay, B. A. (1999). The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell, 98, 453-463.

  • Hawkins, C. J., Wang, S. L., and & Hay, B. A. (1999). A cloning method to identify caspases and their regulators in yeast: Identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1. PNAS, 96, 2885-2890.
1997
  • Hay, B. A., Maile, R., and Rubin, G. M. P element insertion-dependent gene activation in the Drosophila eye. (1997). PNAS , 94, 5195-5200.
1995
  • Hay, B. A., Wassarman, D., and Rubin, G.M. (1995). Drosophila homologs of baculovirus inhibitors of apoptosis proteins function to block death. Cell 83, 1253-1262.
1994
  • Hay, B. A., Wolff, T., and Rubin, G.M. (1994). Expression of baculovirus P35 prevents cell death in Drosophila. Development 120, 2121-2129.
1992
  • Jongens, T.A., Hay, B. A., Jan, L.Y. and Jan, Y.N. (1992). The germ cell-less gene product: A posteriorly localized component necessary for germ cell development in Drosophila. Cell 70, 569-584.
1990
  • Hay, B. A., Jan, L.Y. and Jan, Y.N. (1990). Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity. Development. 109, 425-433.
1988
  • Hay, B. A., Jan, L.Y. and Jan, Y.N. (1988). A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases. Cell. 55, 577-587.

  • Hay, B. A., Ackerman, L., Barbel, S.B., Jan, L.Y. and Jan, Y.N. (1988). Identification of a component of Drosophila polar granules. Development 103, 625-640.
1987
  • Hay, B. A., Prusiner, S.B. and Lingappa, V.R. (1987b). Evidence for a secretory form of the cellular prion protein. Biochemsitry 26, 8110-8115.

  • Hay, B. A., Barry, R.A., Lieberburg, I., Prusiner, S.B. and Lingappa, V. (1987a). Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein. Mol.Cell.Biol. 7, 914-920.

  • McKinley, M.P., Hay, B. A., Lingappa, V.L., Lieberburg, I. and Prusiner, S.B. (1987). Developmental expression of the prion protein in brain. Dev. Biol. 121: 105-110.
1984
  • Woody, C.D., Alkon, D.L., and Hay, B. A. (1984). Depolarization-induced effects of Ca2+-calmodulin-dependent protein kinase injection, in vivo, in single neurons of cat motor cortex. Brain Res. 321: 192-197.

  • Alkon, D.L., Farley, J., Sakakibara, M. and Hay, B. A. (1984). Voltage-dependent calcium and calcium-activated potassium currents of a molluscan photoreceptor. Biophys. J. 46: 605-614.

2014 Caltech