Our publications on . .

Neurotransmitter Transporters

All neurotransmitter transporters

 

The GABA transporter GAT1

 

The serotonin transporter SERT

 

These molecules utilize the transmembrane electrochemical gradient for Na+ (and in some cases for other ions) to move neurotransmitter molecules back into the presynaptic cell or into glial cells after the synaptic event. In some cases, this transport actually serves a role in terminating synaptic transmission efficiently. Our laboratory is presently interested in transporters for GABA and for serotonin (5-HT). We study both the detailed physiology of transport, the regulation of transporter density by second messenger pathways, and we are generating knock-in mice with GFP-tagged transporters in order to quantitate membrane densities.

(see annual report).