(papers since 1994 have links to Entrez and Medline, where available)
54. Charnet, P., C. Labarca, R. J. Leonard, N. J. Vogelaar, L. Czyzyk, A. Gouin, N. Davidson and H. A. Lester. (1990) An open-channel blocker interacts with adjacent turns of alpha helices in the nicotinic acetylcholine receptor. Neuron 2, 87-95.
55. Auld, V. J., A. L. Goldin, D. S. Krafte, J. Marshall, J. M. Dunn, W. A. Catterall, H. A. Lester, N. Davidson and R. J. Dunn. (1990) A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel. Proc. Natl. Acad. Sci. USA 87, 7629-7633.
56. Snutch, T. P., J. P. Leonard, M. M. Gilbert, H. A. Lester and N. Davidson. (1990) Rat brain expresses a heterogeneous family of calcium channels. Proc. Natl. Acad. Sci. USA 87, 3391-3395.
57. Guastella, J. G., N. Nelson, H. Nelson, L. Czyzyk, S. Keynan, M. C. Miedel, N. Davidson, H. Lester and B. Kanner. (1990) Cloning and expression of a rat brain GABA transporter. Science 249, 1303-1306.
58. Krafte, D. S., A. L. Goldin, V. J. Auld, R. J. Dunn, N. Davidson and H. A. Lester. (1990) Inactivation of cloned Na channels expressed in Xenopus oocytes. J. General Physiol. 96, 689-706.
59. Ahmed, C.M.I., V. J. Auld, H. A. Lester, R. Dunn and N. Davidson. (1990) Both sodium channel II and IIA alpha subunits are expressed in rat brain. Nucl. Acids Res. 18, 5907.
60. Hoger, J. H., B. Rudy, H. A. Lester and N. Davidson. (1991) Characterization of maintained voltage-dependent K channels induced in Xenopus oocytes by rat brain mRNA. Molec. Brain Res. 10, 1-11.
61. Karschin, A., J. Aiyar, A Gouin, N. Davidson and H. Lester. (1991) K channel expression in primary cell cultures mediated by vaccinia virus. FEBS Lett. 278, 229-233.
62. Hoger, J. H., A. E. Walter, D. Vance, L. Yu, H. A. Lester and N. Davidson. (1991) Modulation of a cloned mouse brain potassium channel. Neuron 6, 1-10.
63. Yu, L., R. J. Leonard, N. Davidson and H. A. Lester. (1991) Single-channel properties of mouse-Torpedo acetylcholine receptor hybrids expressed in Xenopus oocytes. Mol. Brain Res. 10, 203-211.
64. Yang, X.-C., A. Karschin, C. Labarca, O. Elroy-Stein, B. Moss, N. Davidson and H. A. Lester. (1991). Expression of ion channels and receptors in Xenopus oocytes using vaccinia virus. FASEB J. 5, 2209-2215.
65. Karschin, A., B. Y. Ho, C. Labarca, O. Elroy-Stein, B. Moss, N. Davidson and H. A. Lester. (1991) Heterologously expressed serotonin 1A receptors couple to muscarinic K+ channels in heart. Proc. Natl. Acad. Sci. USA 88, 5694-5698.
66. Walter, A. E., J. H. Hoger, C. Labarca, L. Yu, N. Davidson and H. A. Lester. (1991) Low molecular weight mRNA encodes a protein(s) that controls the serotonin 5-HT1c and acetylcholine M1 receptor sensitivity in Xenopus oocytes. J. Gen. Physiol. 98, 399-417.
67. Yu, L., H. Nguyen, H. Lee, L. J. Bloem, C. A. Kozak, B. J. Hoffman, T. P. Snutch, H. A. Lester, N. Davidson and H. Lubbert. (1991) The mouse 5-HT1C receptor contains 8 hydrophobic domains and is X-linked. Mol. Brain Res.11, 143-149.
68. Dascal, N., G. Chilcott, and H. A. Lester. (1991) Recording of voltage and Ca2+dependent currents in Xenopus oocytes using an intracellular perfusion method. J. Neurosci. Methods 39, 29-38.
69. Yang, X.-C., Labarca, O. Elroy-Stein, B. Moss, N. Davidson and H. A. Lester. (1992) Cell-specific posttranslational events affect functional expression at the plasma membrane but not tetrodotoxin sensitivity of the rat brain IIA sodium channel a subunit expressed in mammalian cells. J. Neurosci. 12, 268-277.
70. Cohen, B. N., C. Labarca, L. Czyzyk, N. Davidson and H. A. Lester. (1992) TRIS+ Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region. J. Gen Physiol. 99, 545-572.
71. Charnet, P., C. Labarca, B. N. Cohen, N. Davidson, H. A. Lester and G. Pilar. (1992) Pharmacological and kinetic properties of a4b2 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J. Physiol. 450, 375-394.
72. Ho, B. Y., A. Karschin, J. R. Raymond, T. Branchek, H. A. Lester and N. Davidson. (1992) Expression in animal cells of the 5-HT1A receptor by a vaccinia virus vector system. FEBS 301, 303-306.
73. Charnet, P., C. Labarca and H. A. Lester. (1992) Structure of the g-less nicotinic acetylcholine receptor: learning from omission. Mol. Pharm. 41, 708-717.
74. Quick, M. W., J. Naeve, N. Davidson and H. A. Lester. (1992) Incubation with horse serum increases viability and decreases background GABA transport in Xenopus oocytes. Biotechniques 13, 358-362.
75. Cohen, B. N., C. Labarca, N. Davidson and H. A. Lester. (1992) Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and for alkali metal cations. J. Gen. Physiol. 100, 373-400.
76. Ho, B. Y., A. Karschin, T. Branchek, N. Davidson and H. A. Lester. (1992) The role of conserved aspartate and serine residues in ligand binding and in function of the 5-HT1A receptor: a site-directed mutation study. FEBS Lett. 312, 259-262.
77. Guastella, J., N. Brecha, C. Weigmann, H. A. Lester, and N. Davidson. (1992) Cloning, expression and localization of a rat brain high affinity glycine transporter. Proc. Natl. Acad. Sci. USA 89, 7189-7193.
78. Figl, A., B. N. Cohen, M. W. Quick, N. Davidson and H. A. Lester. (1992) Regions of b4 b2 subunit chimeras that contribute to the agonist selectivity of neuronal nicotinic receptors. FEBS Lett. 308, 245-248.
79. Mager, S., J. Naeve, M. Quick, C. Labarca, N. Davidson and H. A. Lester. (1993) Steady states, charge movements and rates for a cloned GABA transporter expressed in Xenopus oocytes. Neuron 10, 177-188.
80. McCarty, N. A., S. McDonough, B. N. Cohen, J. R. Riordan, N. Davidson, and H. A. Lester. (1993) Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates. J. Gen. Physiol. 102, 1-23.
81. Uezono, Y., J. Bradley, C. Min, N. McCarty, M. Quick, J. R. Riordan, C. Chavkin, K. Zinn, H. A. Lester and N. Davidson. (1993) Receptors that couple to two classes of G proteins increase cAMP and activate CFTR expressed in Xenopus oocytes. Receptors and Channels, 1, 233-241.[Medline]
82. Hsu, H., E. Huang, X.-C. Yang, A. Karschin, C. Labarca, A. Figl, B. Ho, N. Davidson, and H. A. Lester. (1993) Slow and incomplete inactivations of voltage-gated channels dominate encoding in synthetic neurons. Biophys. J. 65, 1196-1206.
83. Dascal, N., N. F. Lim, W. Schreibmayer, W. Wang, N. Davidson and H. A. Lester. (1993) Expression of an atrial G-protein-activated potassium channel in Xenopus oocytes. Proc. Natl. Acad. Sci. USA 90, 6596-6600.
84. Slepak, V. Z., M. W. Quick, A. M. Aragay, N. Davidson, H. A. Lester and M. I. Simon. (1993) Random mutagenesis of G protein a subunit Goa: Mutations altering the nucleotide binding. J. Biol. Chem. 268, 21889-21894.
85. Dascal, N., W. Schreibmayer, N. F. Lim, W. Wang, C. Chavkin, L. DiMagno, C. Labarca, B. L. Kieffer, C. Gaveriaux-Ruff, D. Trollinger, H. A. Lester, and N. Davidson. (1993) Atrial G protein-activated K+ channel: Expression cloning and molecular properties. Proc. Natl. Acad. Sci. USA 90, 10235-10239.
86. Corey, J. L., J. Guastella, N. Davidson and H. A. Lester. (1994) GABA uptake and release by a mammalian cell line stably expressing a cloned rat brain GABA transporter. Mol. Memb. Biol. 11, 23-30.[Medline]
87. Corey, J. L., Quick, M. W., Davidson, N., Lester, H. A., and Guastella, J. (1994) A cocaine-sensitive Drosophila serotonin transporter: Cloning, expression, and electrophysiological characterization. Proc. Natl. Acad. Sci. USA 91, 1188-1192.[Medline]
88. Corey, J. L., Davidson, N., Lester, H. A. Brecha, N., and Quick, M. W. (1994) Protein kinase C modulates the activity of a cloned GABA transporter expressed in Xenopus oocytes via regulated subcellular redistribution of the transporter. J. Biol. Chem. 269, 14759-14767.[Medline]
89. Mager, S., Min, C., Henry, D. J., Chavkin, C., Hoffman, B. J., Davidson, N., and Lester, H. A. (1994) Conducting states of a mammalian serotonin transporter. Neuron 12, 1-20.[Medline]
90. Schreibmayer, W., H. A. Lester, and N. Dascal. (1994) Voltage clamping of Xenopus laevis oocytes utilizing agarose-cushion electrodes. Pfügers Arch. 426, 453-458.
91. Bradley, J, Li, J., Davidson, N., Lester, H. A., and Zinn, K. G. (1994) Heteromeric olfactory cyclic nucleotide-gated channels: a new subunit that confers increased sensitivity to cAMP. Proc. Natl. Acad. Sci. USA 91, 8890-8894.[Medline]
92. Karschin, C., Lester, H., Davidson, N., and Karschin, A. (1994) Distribution and localization of a G protein-coupled inwardly rectifying K+ channel in the rat. FEBS Lett. 348, 139-144.[Medline]
93. McDonough, S., Davidson, N., Lester, H. A., and McCarty, N. (1994) Novel pore-lining residues in CFTR that govern permeation and open channel block. Neuron 13, 623-634.[Medline]
94. Karschin, A., Wischmeyer, E., Davidson, N., and Lester, H. A. (1994) Fast inhibition of inwardly rectifying K+ channels by multiple neurotransmitter receptors in oligodendroglia. Eur. J. Neurosci., 6, 1756-1764.
95. Quick. M. W., Simon, M. I., Davidson, N., Lester, H. A., and Aragay, A. (1994) Differential coupling of G protein a subunits to seven-helix receptors expressed in Xenopus oocytes. J. Biol. Chem. 269, 30164-30172.[Medline]
96. Cohen, B. N., Figl, A., Quick, M. W., Labarca, C., Davidson, N., and Lester, H. A. (1995) Regions of b2 and b4 responsible for differences between the equilibrium dose-response relationships of the a3b2 and a3b4 neuronal nicotinic receptors. J. Gen Physiol., 105, 745-754.[Medline]
97. Schreibmayer, W., Frohnwieser, B., Dascal, N., Platzer, D., Spreitzer, B., Zechner, R., Kallen, R. G., and Lester, H. A. (1994) b-adrenergic modulaton of rat cardiac Na+ channels expressed in Xenopus laevis oocytes. Receptors and Channels 2, 339-350.[Medline]
98. Lim, N. F., Dascal, N., Labarca, C., Davidson, N., and Lester, H. A. (1995) A G protein-gated K channel is activated via b2-adrenergic receptors and Gbg subunits in Xenopus oocytes. J. Gen Physiol. 105, 421-439.
99. Henry, D. J., Grandy, D., Lester, H. A., Davidson, N., Lim, N.F., and Chavkin, C. (1995) Kappa opioid receptors couple to inwardly rectifying potassium channels when coexpressed by Xenopus oocytes. Molec. Pharmacol. 47, 551-557.[Medline]
100. Nowak, M. W., Kearney, P. C., Sampson, J. R., Saks, M. E., Labarca, C. G., Silverman, S. K., Zhong, W., Thorson, J., Abelson, J. N., Davidson, N., Schultz, P. G., Dougherty, D. A., and Lester, H. A. (1995) Nicotinic receptor binding site probed with unnatural amino-acid incorporation in intact cells. Science 268, 439-442.
101. Doupnik, C. A., Lim, N. F., Kofuji, P., Davidson, N., and Lester, H. A (1995). Intrinsic gating properties of a cloned G protein-activated inward rectifier K+ channel. J. Gen. Physiol. 105, 1-23.
102. Labarca, C., Nowak, M. W., Zhang, H., Tang, L., Deshpande, P., and Lester, H. A. (1995). Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature 376, 514-516.[Medline]
Dr. Pat Kearney's further analysis
103. Bausch, S. B., Patterson, T. A., Ehrengruber, M. U., Lester, H. A., Davidson, N., and Chavkin, C. (1995) Colocalization of mu opioid receptors with GIRK1 potassium channels in rat brain: An immunocytochemical study. Receptors and Channels, in press.
104. Kofuji, P., Davidson, N., and Lester, H. A. (1995).Evidence that neuronal G protein-gated inwardly rectifying K+ channels are activated by Gbg subunits and function as heteromultimers. Proc. Natl. Acad. Sci. USA 92, 6542-6546.[Medline]
105. Nathan Dascal, Craig A. Doupnik, Tatiana Ivanina, Suzanne Bausch, Weizhen Wang, Catherine Lin, Justine Garvey and Charles Chavkin (1995). Inhibition of function in Xenopus oocytes of the G protein-activated atrial K channel (GIRK1) by over-expression of a membrane attached form of the C-terminal tail. Proc. Natl. Acad. Sci. USA 92, 6758-6762. [Medline]
106. Kofuji, P., Doupnik, C., Davidson, N., and Lester, H. A. (1995). A unique P-region residue is required for slow voltage-dependent gating of a G protein-activated inward rectifier K+ channel. J. Physiol. in press
107.Keshet, G. I., Bendahan, A., Su, H., Mager, S., Lester, H. A. and B. I. Kanner (1995) Glutamate-101 is critical for the function of the sodium and chloride-coupled GABA transporter GAT-1. FEBS Lett 371: 39-42. [Medline]
108. Su, A., Mager, S., Mayo, S. L. and Lester, H. A. (1995) A multi-substrate single-file model for ion-coupled transporters. Biophys. J. 70, 762-777.
109. Figl, A., Labarca, C., Davidson, N., Lester, H. A. and Cohen, B. N. (1995) Voltage-jump relaxation kinetics for wild type and chimeric b subunits of neuronal nicotinic receptors. J. Gen.Physiol., in press.
110. Wolfgang Schreibmayer, Carmen W. Dessauer, Dimitry Vorobiov, Alfred G. Gilman, Henry A. Lester, Norman Davidson, Nathan Dascal. (1996) Antagonistic modulation of an inward rectifier K+ (GIRK) channel by a and bg subunits of G proteins. Nature, in press
17. Leonard, R. J., P. Charnet, C. Labarca, N. J. Vogelaar, L. Czyzyk, A. Gouin, N. Davidson and H. A. Lester. (1991) Reverse pharmacology of the nicotinic acetylcholine receptor: Mapping the local anesthetic binding site. Ann. N.Y. Acad. Sci., Vol. 625, E. Rubin, K. W. Miller and S. H. Roth (Eds.). N.Y. Acad. Sci., pp. 588-599.
18. Lester, H. A. (1991) Strategies for studying permeation at voltage-gated ion channels. Ann. Rev. Physiol. 53, 477-496.
19. Karschin, A., B. A. Thorne, G. Thomas, and H. A. Lester. (1992) Vaccinia virus as a vector to express ion channel genes. Meth. Enzymol., vol. 207, Ion Channels, B. Rudy and L. E. Iverson, Eds., Academic Press, San Diego, pp. 408-422.
20. Krafte, D. S. and H. A. Lester. (1992) Expression of ion currents in small oocytes. Meth. Enzymol., vol. 207, Ion Channels, B. Rudy and L. E. Iverson, Eds., Academic Press, San Diego, pp. 339-344.
21. Dascal, N., G. Chilcott, and H. A. Lester. (1992) Intracellular perfusion of oocytes. Meth. Enzymol., vol. 207, Ion Channels, B. Rudy and L. E. Iverson, Eds., Academic Press, San Diego, pp. 345-352.
22. Lester, H. A. (1992) The permeation pathway of neurotransmitter-gated ion channels. Annu. Rev. Biophys. Biomol. Struct. 21:267-292.
23. Nargeot, J., N. Dascal and H. A. Lester. (1992) Heterologous expression of calcium channels. J. Memb. Biol. 126, 97-108.
24. Quick, M. W., and H. A. Lester (1994) Methods for expression of excitability proteins in Xenopus oocytes. In Ion Channels of Excitable Cells, T. Narahashi, ed. , Academic Press, pp. 261-279.
25. Lester, H. A. and N. Dascal (1993) Potassium channels: the response to vagusstoff. Nature 364, 758-759.
26. Lester, H. A., S. Mager, M. W. Quick, and J. L. Corey. (1994) Permeation properties of neurotransmitter transporters. Ann. Rev. Pharmacol. and Toxicol. 34: 219-249.
27. McDonough, S., and Lester, H. A. An overview of the relationship between structure and function in ion channels. Drug Dev. Res. 33, 190-202.
28. Doupnik, C. A., Davidson, N. and Lester, H. A. (1995) The inward rectifier potassium channel family. Curr. Opin. Neurobiol. 5, 268-277. [Medline]
