Cell adhesion at the synapse

Morphological changes at synapses are one mechanism to achieve long-term synaptic plasticity. Activity-dependent changes at synapses are likely orchestrated by cell adhesion molecules (CAMs), which mediate synaptic connections and interact with the cytoskeleton. Cadherins are a family of CAMs, present at synaptic sites and involved in long-term potentiation. We are studying how cadherins and their cytoplasmic signaling partner, beta-catenin, modify and maintain synaptic connections.

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