Selected Publications:
·
Charge-Transfer Heptamethine Dyes for NIR
Singlet Oxygen Generation. J. B. Jarman and D. A. Dougherty, ChemComm. 2019, 55, 551-5514.
·
A General Strategy for Visible-Light Decaging
Based on the Quinone Cis-Alkenyl Lock, D. P. Walton and D. A. Dougherty, ChemComm. 2019, 55, 4965-4968.
- Determining the
Pharmacokinetics of Nicotinic Drugs in the Endoplasmic Reticulum Using Biosensors,
A. V. Shivange, P. M. Borden, A. K. Muthusamy, A. L. Nichols, K. Bera, H.
Bao, I. Bishara, J. Leon, M. J. Mulcahy, B. N. Cohen, S. L. O’Riordan, C.
H. Kim, D. A. Dougherty, E. R. Chapman, J. S. Marvin, L. L. Looger, H. A.
Lester, J. Gen. Physiol., in press.
- Probing proline residues in
the prokaryotic ligand-gated ion channel, ELIC, R. Mosesso, D. A.
Dougherty, S. C. R. Lummis, Biochemistry, 2018, 57, 4036-4043.
- A Triad of Residues is
Functionally Transferrable Between 5-HT3 Serotonin Receptors and Nicotinic
Acetylcholine Receptors, R. Mosesso, D. A. Dougherty, J. Biol. Chem. 2018,
293, 2903-2914;
doi:10.1074/jbc.M117.810432.
- The Cation-π Interaction, D.
A. Dougherty, in Intermolecular Interactions in Crystals: Fundamentals of
Crystal Engineering, J. J. Novoa, Ed., Royal Society of Chemistry Press,
2018, 516-529.
- A General Strategy for
Visible-Light Decaging Based on the Quinone Trimethyl Lock, D. P. Walton,
D. A. Dougherty, J. Am. Chem. Soc., 2017, 139, 4655-4658. DOI:
10.1021/jacs.7b01548
- Probing for and Quantifying
Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors, M. R.
Post, H. A. Lester, D. A. Dougherty, Biochemistry, 2017, 56,
1836-1840. DOI: 10.1021/acs.biochem.7b00213
- Secondary Ammonium Agonists
Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors, M. R. Post,
G. S. Tender, H. A. Lester, D. A. Dougherty, eNeuro,.
March/April 2017, 4(2) e0032-17.2017 1–8; DOI:http://dx.doi.org/10.1523/-ENEURO.0032-17.2017
- Mechanistic Studies of the
Photoinduced Quinone Trimethyl Lock Decaging Process, C. J. Regan, D. P.
Walton, O. S. Shafaat, D. A. Dougherty, J. Am. Chem. Soc., 2017, 139,
4729-4736. DOI: 10.1021/jacs.6b12007
- Photoactivation of an
Acid-Sensitive Ion Channel Associated with Vision and Pain, O.S. Shafaat,
J.R. Winkler, H.B. Gray, D.A. Dougherty, ChemBioChem, 2016, 17,
1323-1327
- Mutation Linked to Autosomal
Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity alpha 4
beta 2, and Increases alpha 5 alpha 4 beta 2, Nicotinic Receptor Surface
Expression, W.A. Nichols, B.J. Henderson, C.B. Marotta, C.Y. Yu, C.
Richards, D.A. Dougherty, H.A. Lester, and B.N. Cohen, PLOS ONE, 2016,
11, e0158032
- Perturbation of Critical
Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports
Conserved Gating Motions among Cys-loop Receptors. M. Rienzo, A.R. Rocchi,
S.D. Threatt, D.A. Dougherty, S.C. Lummis, J Biol Chem., 2016,
12, 6272-80.
- Cation-π interactions:
computational analyses of the aromatic box motif and the fluorination
strategy for experimental evaluation. M.R. Davis, D.A. Dougherty, Phys
Chem Chem Phys., 2015, 43, 29262-70.
- An Unaltered Orthosteric Site
and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7
Nicotinic Acetylcholine Receptors. C.B. Marotta, H.A. Lester, D.A.
Dougherty, Chem Biol., 2015, 8, 1063-73.
- Ketamine inside neurons? H.A.
Lester, L.D. Lavis, D.A. Dougherty, Am J Psychiatry, 2015, 11,
1064-6.
- Heterologous Expression and
Nonsense Suppression Probe Agonist Behaviors at α6β2 Nicotinic Receptors,
M.R Post, W. Limapichat, H. A Lester, D. A Dougherty, Neuropharm., 2015,
97, 376-382.
- The nicotinic α6 subunit gene
determines variability in chronic pain sensitivity via cross-inhibition of
P2X2/3 receptors, J.S. Wieskopf, J. Mathur, W. Limapichat, M.R. Post, M.
Al-Qazzaz, R.E. Sorge, L.J. Martin, D.V. Zaykin, S.B. Smith, K. Freitas,
J-S Austin, F. Dai, J. Zhang, J. Marcovitz, A.H. Tuttle, P.M. Slepian, S.
Clarke, R.M. Drenan, J. Janes, S. Al Sharari, S.K. Segall, E.K. Aasvang,
W. Lai, R. Bittner, C.I. Richards, G.D. Slade, H. Kehlet, J. Walker, U.
Maskos, J-P. Changeux, M. Devor, W. Maixner, L. Diatchenko, I. Belfer,
D.A. Dougherty, A.I. Su, S.C.R. Lummis, M.I. Damaj, H.A. Lester, A.
Patapoutian, J.S. Mogil, Sci Transl Med , 2015, 7,
287ra72.
- Allosteric activation of the
5-HT3AB receptor by mCPBG, T.F. Miles, H.A. Lester, D.A.
Dougherty, Neuropharm., 2015, 97, 103-108; PMCID:PMC4312754
- Structural Requirements in
the Transmembrane Domain of GLIC Revealed by Incorporation of Noncanonical
Histidine Analogs, M. Rienzo, S.C. Lummis, D.A. Dougherty, ACS Chem
Biol., 2014, 21, 1700-6.
- Functional Evaluation of Key
Interactions Evident in the Structure of the Eukaryotic Cys-Loop Receptor
GluCl, K.N. Daeffler, H.A. Lester, D.A. Dougherty, ACS Chem Biol., 2014,
9, 2283-90.
- In vivo incorporation of
non-canonical amino acids by using the chemical aminoacylation strategy: a
broadly applicable mechanistic tool, D.A. Dougherty, E.B. Van Arnam, Chembiochem.,
2014, 15, 1710-20.
- Subtype-specific mechanisms
for functional interaction between α6β4* nicotinic acetylcholine receptors
and P2X receptors, W. Limapichat, D.A. Dougherty, H.A. Lester, Mol
Pharmacol., 2014, 86, 263-74. DOI:
10.1124/mol.114.093179
- Functional probes of
drug-receptor interactions implicated by structural studies: Cys-loop
receptors provide a fertile testing ground, E.B. Van Arnam, D.A.
Dougherty, J Med Chem., 2014, 57, 6289-300.
- Selective ligand behaviors
provide new insights into agonist activation of nicotinic acetylcholine
receptors, C.B. Marotta, I. Rreza, H.A. Lester, D.A. Dougherty, ACS
Chem Biol., 2014, 9, 1153-9.
- Probing the Non-Canonical
Interface for Agonist Interaction with an α5 Containing Nicotinic Acetylcholine
Receptor, C.B. Marotta, C.N. Dilworth, H.A. Lester, D.A. Dougherty, Neuropharm.,
2013, 77, 342-349.
- The 5-HT3AB receptor shows an
A3B2 stoichiometry at the plasma membrane, T. F. Miles, D. A. Dougherty,
and H. A. Lester, Biophys. J., 2013, 105, 887-898.
- An unusual pattern of
ligand-receptor interactions for the α7 nicotinic acetylcholine receptor,
with implications for the binding of varenicline, E. B. Van Arnam, E. E.
Blythe, H. A. Lester, and D. A. Dougherty, Mol. Pharm., 2013,
84, 201-207. PMCID:PMC3716316
- Binding Interactions To The Complementary Subunit Of Nicotinic Receptors A.
P. Blum, E. B. Van Arnam, L. A. German, H. A. Lester, and D. A. Dougherty,
J. Biol. Chem., 2013, 288, 6991-6997. PMCID:
PMC3591609
- The Cation-π Interaction,
D.A. Dougherty, Accts. Chem. Res., 2013, 46, 885-893.
- Key Binding Interactions for
Memantine in the NMDA Receptor, W. Limapichat, W. Yu, E. Branigan, H. A.
Lester, D. A. Dougherty, ACS Chem. Neurosci., 2013, 4,
255-260.
- GABA Binding to an Insect
GABA Receptor: A Molecular Dynamics and Mutagenesis Study, J. A. Ashby, I.
V. McGonigle, K. L. Price, N. Cohen, F. Comatini, D. A. Dougherty, C.
Molteni, S. C. R. Lummis, Biophys. J., 2012, 103,
2071-2081. PMCID: PMC3512037
- Forster Resonance Energy
Transfer (FRET) correlates of altered subunit stoichiometry in Cys-loop
receptors, exemplified by nicotinic α4β2 R. Srinivasan, C. I. Richards, C.
Dilworth, F. J. Moss, D. A. Dougherty, and H. A. Lester, Int. J. Mol.
Sci., 2012, 13, 10022-10040. PMCID: PMC3431844
- Live-Cell Imaging of Single
Receptor Composition Using Zero-Mode Waveguide Nanostructures, C.
Richards, K. Luong, R. Srinivasan, S. Turner, D. A. Dougherty, H. A.
Lester, Nano Lett., 2012, 12, 3690-3694. PMCID:
PMC3397148
- Pentameric ligand-gated ion
channel ELIC is activated by GABA and modulated by benzodiazepines, D.
Bertrand, H. Nury, S. Lummis, D. A. Dougherty, M. Veheij, P. Legrand, J.
Ramerstorfer, R. Spurny, Proc. Natl. Acad. Sci., 2012, 109,
E3028-E3034. PMCID:PMC3497736
- Functionally Important
Aromatic-Aromatic and Sulfur-π Interactions in the D2 Dopamine Receptor,
K. N. M. Daeffler, H. A. Lester, D. A. Dougherty, J. Am. Chem. Soc.,
2012, 134, 14890-14896. PMCID: PMC3461201
- Ondansetron and Granisetron
Binding Orientation in the 5-HT3 Receptor Determined by Unnatural Amino
Acid Mutagenesis, N. H. Duffy, H. A. Lester, D. A. Dougherty, ACS Chem.
Biol., 2012, 7, 1738-1745. DOI: 10.1021/cb300246j.
PMCID: PMC:3477246
- A Coupled Array Of Noncovalent Interactions Impacts The Function Of The
5-HT3A Serotonin Receptor In An Agonist-Specific Way, T. F. Miles, K. S.
Bower, H. A. Lester, D. A. Dougherty, ACS Chem. Neurosci., 2012,
3, 753-760. DOI: 10.1021/cn3000586. PMCID: PMC3474281
- Variations in Binding Among
Several Agonists at Two Stoichiometries of the Neuronal, α4β2 Nicotinic
Receptor, X. Da Silva Tavares, A. P. Blum, D. T. Nakamura, N. L. Puskar,
J. A. P. Shanata, H. A. Lester, D. A. Dougherty, J. Am Chem. Soc., 2012,
134, 11474-11480. PMCID: PMC3399941
- Pharmacological Chaperoning
of Nicotinic Acetylcholine Receptors Reduces the ER Stress Response. R.
Srinivasan, C. I. Richards, D. Rhee, R. Pantoja, D. A. Dougherty, J. M.
Miwa, H. A. Lester, Mol. Pharmacol., 2012, 81,
759-769. PMCID: PMC3362896
- Probing the Effects of
Residues Located Outside the Agonist Binding Site on Drug-Receptor
Selectivity in the Nicotinic Receptor, N. L. Puskar, H. A. Lester, D. A.
Dougherty, ACS Chem. Biol., 2012, 7, 841-846. PMCID:
PMC3356501
- Multiple Tyrosine Residues Contribute
To GABA Binding In The GABAC Receptor Binding
Pocket, S. C. R. Lummis., N. J Harrison, J. Wang, J. A. Ashby, K. S.
Millen, D. L. Beene and D. A. Dougherty, ACS Chem. Neurosci., 2012,
3 (3), 186-192. PMCID: PMC3309607
- Using Mutant Cycle Analysis to
Elucidate Long-Range Functional Coupling in Allosteric Receptors, J. A. P.
Shanata, S. J. Frazier, H. A. Lester, and D.A. Dougherty, in Allostery,
Methods and Protocols, A. W. Fenton, Ed., 2012, Springer, New
York, pp 97-113. doi: 10.1007/978-1-61779-334-9_6.
- Dissecting the functions of
conserved prolines within transmembrane helices of the D2 dopamine
receptor, E. B. Van Arnam, H. A. Lester, D. A. Dougherty, ACS Chem.
Biol., 2011, 6, 1063-1068. PMCID: PMC3199346
- Evidence for an Extended
Hydrogen Bond Network in the Binding Site of the Nicotinic Receptor:
Concerning the Role of the Vicinal Disulfide of the α1 Subunit, A. P.
Blum, K. R. Gleitsman, H. A. Lester, and D. A. Dougherty, J. Biol.
Chem., 2011, 286, 32251-32258. PMCID: PMC3173184
- Two amino acid residues
contribute to a Cation-π Binding Interaction in the Binding Site of an
insect GABA receptor, S.C.R. Lummis, I. McGonigle, J.A. Ashby and D.A.
Dougherty, J. Neurosci., 2011, 31, 12371-12376.
PMCID: PMC3233689
- Two Neuronal Nicotinic
Acetylcholine Receptors – α4β4 and α7 – Show Differential Ligand Binding
Modes, N.L. Puskar, X. Xiu, H.A. Lester, D.A. Dougherty, J. Biol. Chem.,
2011, 286, 14618-14627. PMCID PMC3077659
- A Cation-π Interaction at a
Phenylalanine Residue in the Glycine Receptor Binding Site is Conserved
for Different Agonists, S.A. Pless, A.P. Hanek, K.L. Price, J.W. Lynch,
H.A. Lester, D.A. Dougherty, and S.C.R. Lummis, Mol. Pharm., 2011,
79, 742-748. PMCID PMC3063724
- A Room-Temperature
Alternative to the Arbuzov Reaction: the
Reductive Deoxygenation of Acyl Phosphonates, S.M.A. Kedrowski, D.A.
Dougherty, Org. Lett., 2010, 12, 3990-3993. PMCID:
PMC2941390
- Preparation of
Translationally Competent tRNA by Direct Chemical Acylation, N.H. Duffy,
D.A. Dougherty, Org. Lett.,2010, 12, 3776-3779. PMCID:
PMC2929286
- The nicotinic pharmacophore:
The polar groups of ACh and nicotine hydrogen bond across a subunit
interface to a backbone NH, A. P. Blum, H. A. Lester, D. A. Dougherty, Proc.
Natl. Acad. Sci., 2010, 107, 13206-13211.
- A Gating Charge Transfer Center
in Voltage Sensors X. Tao, A. L. MacKinnon, W. Limapichat, D. A.
Dougherty, R. MacKinnon,*, Science, 2010,
328, 67-73.
- Chemical-Scale Studies of the
Phe-Pro Conserved Motif in the Cys-loop of Cys-loop Receptors, W.
Limapichat, H.A. Lester, D.A. Dougherty, J. Biol. Chem., 2010,
285, 8976-8984.
- Photochemical Proteolysis of
an Unstructured Linker of the GABAAR Extracellular Domain prevents GABA
but not Pentobarbital Activation, A.P. Hanek, H.A. Lester, D.A. Dougherty,
Mol. Pharm. 2010, 78, 29-35.
- Nicotine Binding to Brain
Receptors Requires a Strong Cation-π Interaction X. Xiu*, N.L. Puskar*,
J.A.P. Shanata, H.A. Lester, and D.A. Dougherty, Nature, 2009,
458, 534-537.
- An Electrostatic Interaction
between TEA and an Introduced Pore Aromatic drives
Spring-in-the-Door Inactivation in Shaker Potassium Channels, C.A. Ahern,
A.L. Eastwood, D.A. Dougherty, R. Horn, J. Gen. Phys. 2009, 134,
461-469.
- Probing the Role of the Cation-π
Interaction in the Binding Sites of GPCRs Using Unnatural Amino Acids,
M.M. Torrice, K.S. Bower, H.A. Lester, D.A. Dougherty, Proc. Natl.
Acad. Sci., 2009, 106, 11919-11924.
- Probing the Role of Backbone
Hydrogen Bonding in a Critical β-sheet of the Extracellular Domain of a
Cys-loop Receptor, K.R. Gleitsman, H.A. Lester, D.A. Dougherty, ChemBioChem,
2009, 10, 1385-1391.
- Nicotine is a Selective Pharmacological
Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications
for Drug Discovery, H.A. Lester, C. Xiao, R. Srinivasan, C. Son, J. Miwa,
R. Pantoja, D.A. Dougherty, M. R. Banghart, A. M. Goate, J. C. Wang, and
L. J. Bierut, AAPS Journal, 2009, 11, 167-177.
- A Selenide-Based Approach to
Photochemical Cleavage of Peptide and Protein Backbones at Engineered
Backbone Esters, A.L. Eastwood*, A.P. Blum*, N.M. Zacharias, D.A.
Dougherty, J. Org.Chem., 2009, 74, 9241-9244.
- An Intersubunit Hydrogen Bond
in the Nicotinic Acetylcholine Receptor that Contributes to Channel
Gating, K.R. Gleitsman*, S.M.A. Kedrowski*, H.A. Lester and D.A.
Dougherty, J. Biol. Chem, 2008, 283, 35638-35643.
- Long-Range Coupling in an
Allosteric Receptor Reveals a Residue’s Function, K.R. Gleitsman*, J.A.P.
Shanata*, S.J. Frazier, H.A. Lester, and D.A. Dougherty, Biophys.J.,
2009, 96, 3168-3178.
- A Cation-π Interaction in The
Binding Site of The Glycine Receptor Mediated by a Phenylalanine Residue,
S.A. Pless, K.S. Millen, A.P. Hanek, J.W. Lynch, H.A. Lester, S.C.R.
Lummis, and D.A. Dougherty, J. Neurosci., 2008, 28,
10937-10942.
- Single-molecule Imaging of a
Fluorescent Unnatural Amino Acid Incorporated into Functional Nicotinic
Acetylcholine Receptors, R. Pantoja, E. A. Rodriguez, M.I. Dibas, D.A.
Dougherty, and H.A. Lester Biophys. J., 2009, 96,
226-237.
- Long-Range Coupling in an
Allosteric Receptor Reveals a Residue’s Function, K. R. Gleitsman*, J. A.
P. Shanata*, S. J. Frazier, H. A. Lester, and D. A. Dougherty, Biophys.J.,
2009, 96, 3168-3178.
- A Stereochemical Test of a
Proposed Mechanism for Nicotinic Receptor Gating, A. P. Hanek, H. A.
Lester and D. A. Dougherty, J. Am. Chem. Soc., 2008, 130,
13216-13218.
- An Intersubunit Hydrogen Bond
in the Nicotinic Acetylcholine Receptor that Contributes to Channel
Gating, K.R. Gleitsman*, S.M.A. Kedrowski*, H.A. Lester and D.A.
Dougherty, J. Biol. Chem, 2008, 283, 35638-35643.
- A hydrogen bond in Loop A is
critical for binding and function of the 5-HT3 receptor. K. L.
Price, K.S. Bower, A.J. Thompson, H.A. Lester, D.A. Dougherty, and S.C.R.
Lummis, Biochemistry, 2008, 47, 6370-6377.
- Physical Organic Chemistry on
the Brain, D.A. Dougherty, J. Org. Chem. 2008, 73, 3667-3673.
- Cys-loop Neuroreceptors:
Structure to the Rescue?, D.A. Dougherty, Chem.
Rev., 2008, 108, 1642-1653.
- Electrostatic Contributions
of Aromatic Residues in the Local Anesthetic Receptor of Voltage-gated
Sodium Channels, C.A. Ahern, A.L. Eastwood, D.A. Dougherty, and R. Horn, Circulation
Res., 2008, 102, 86-94.
- Confirming the Revised
C-terminal Domain of the MscL Crystal Structure, J.A. Maurer, D.E. Elmore,
D. Clayton, H.A. Lester, D.A. Dougherty, Biophys.J., 2008,
94, 4662–4667.
- Improved Amber and Opal
Suppressor tRNAs for Incorporation of Unnatural Amino Acids In Vivo, Part
2: Evaluating Suppression Efficiency, E. A. Rodriguez, H. A. Lester, D. A.
Dougherty, RNA, 2007, 13, 1715-1722.
- Improved Amber and Opal
Suppressor tRNAs for Incorporation of Unnatural Amino Acids In Vivo, Part
1: Minimizing Misacylation, E. A. Rodriguez, H. A. Lester, D. A.
Dougherty, RNA, 2007, 13, 1703-1714.
- 1-Oxo-5-hydroxytryptamine: A
Surprisingly Potent Agonist of the 5-HT3 (Serotonin) Receptor. S.M.A.
Kedrowski, K.S. Bower, D.A. Dougherty, Org. Lett., 2007, 9,
3205-3207.
- 5-Fluorotryptamine is a
partial agonist at 5-HT3 receptors, and reveals
that size and electronegativity at the 5 position of tryptamine are
critical for efficient receptor function. K.S. Bower, K.L.Price,
L.E. Sturdee, D.A. Dougherty, S.C.R. Lummis, Eur. J. Pharm., 2008,
580, 291-297.
- Reconstitution of Ion
Channels in Agarose-Supported Silicon Orifices, J.A. Maurer, V.E. White,
D.A. Dougherty, J.L. Nadeau, Biosensors Bioelectronics, 2007,
22, 2577-2584.
- Calcium Block of Single
Sodium Channels. Role of a Pore-lining Aromatic Residue, V.P. Santarelli,
A.L. Eastwood, D.A. Dougherty, C.A. Ahern, R. Horn, Biophys. J., 2007,
93, 2341-2349.
- Establishing an Ion Pair in
the GABAC Receptor that Contributes to the Gating Pathway, J.
Wang, H.A. Lester, D.A. Dougherty, J. Biol. Chem., 2007, 282,
26210-26216.
- A Cation-π Interaction
Discriminates Among Sodium Channels that are either Sensitive or Resistant
to Tetrodotoxin Block, V.P. Santarelli, A.L. Eastwood, D.A. Dougherty, R.
Horn, C.A. Ahern, J. Biol. Chem., 2007, 282, 8044-8051.
- Chemical-Scale Studies on the
Role of a Conserved Aspartate in Preorganizing the Agonist Binding Site of
the Nicotinic Acetylcholine Receptor. A.L. Cashin, M.M. Torrice, K.A.
McMenimen, H.A. Lester, D.A. Dougherty, Biochemistry, 2007, 46,
630-639.
- Unnatural Amino Acid
Mutagenesis of the GABAA Receptor Binding Site Residues Reveals
a Novel Cation-π Interaction Between GABA and b2 Tyr97. Padgett C.L.,
Hanek A.P., Lester H.A., Dougherty D.A. and Lummis S.C.R., J. Neurosci.,
2007, 27, 886-892.
- A Cation-π Interaction
between Extracellular TEA and an Aromatic Residue in Potassium Channels,
C.A. Ahern, A.L. Eastwood, H.A. Lester and D.A. Dougherty and R. Horn, J.
Gen. Phys. 2006, 128, 649-657.
- Probing the Mg2+
Blockade Site of an NMDA Receptor with Unnatural Amino Acid Mutagenesis,
K.A. McMenimen, E.J. Petersson, H.A. Lester, D.A. Dougherty, ACS Chem.
Biol., 2006, 1, 227-234.
- Voltage-Dependent Hydration and
Conduction Properties of the Hydrophobic Pore of the MscS Channel. S.A.
Spronk, D.E. Elmore, D.A. Dougherty, Biophys. J., 2006, 90,
3555-3569.
- In Vivo Incorporation
of Multiple Unnatural Amino Acids Using Nonsense and Frameshift
Suppression. E. A. Rodriguez, H. A. Lester, and D. A. Dougherty, Proc.
Natl. Acad. Sci. (USA), 2006, 103, 8650-8655.
- A Unified View of the Role of
Electrostatic Interactions in Modulating the Gating of Cys Loop Receptors.
X. Xiu, A.P. Hanek, J. Wang, H.A. Lester, and D.A. Dougherty, J. Biol.
Chem., 2005, 280, 41655-41666.
- A Cation-pi Binding
Interaction with a Tyrosine in the Binding Site of the GABAC Receptor.
S.C.R. Lummis, D.L. Beene, N.J. Harrison, H.A. Lester, and D.A. Dougherty,
Chem. Biol. 2005, 12, 993-997.
- Cis-trans Isomerization at a
Proline Opens the Pore of a Neurotransmitter-gated Ion Channel. S.C.R.
Lummis, D.L. Beene, L.W. Lee, H.A. Lester, R. William Broadhurst, and D.A.
Dougherty, Nature, 2005, 438, 248-252.
- Caged Phosphoproteins. D.M.
Rothman, E.J. Petersson, M.E. Vázquez, G.S. Brandt, D.A. Dougherty*, B.
Imperiali* J. Am. Chem. Soc., 2005, 127, 846-847.
- Using Physical Chemistry to
Differentiate Nicotinic from Cholinergic Agonists at the Nicotinic
Acetylcholine Receptor. A.L. Cashin, E.J. Petersson, H.A. Lester, and D.A.
Dougherty J. Am. Chem. Soc., 2005, 127, 350-356.
- Cys-loop Receptors: New
Twists and Turns H.A. Lester, M.I. Dibas, D.S. Dahan, J.F. Leite, and D.A.
Dougherty Trends Neurosci., 2004, 27, 329-336.
- Tyrosine Residues That Control
Binding and Gating in the 5-Hydroxytryptamine3 Receptor Revealed by
Unnatural Amino Acid Mutagenesis. D.L. Beene, K.L. Price, H.A. Lester,
D.A. Dougherty, and S.C.R. Lummis, J. Neurosci., 2004, 24,
9097-9104.
- A fluorophore attached to
nicotinic acetylcholine receptor bM2 detects productive binding of agonist
to the ad site. D.S. Dahan, V.A. Auyeung, D.A. Dougherty, and H.A. Lester,
Proc. Natl. Acad. Sci. (USA), 2004, 101, 10195-10200.
- Total chemical synthesis,
vesicle-reconstitution and electrophysiological characterization of the
mechanosensitive channels of large conductance from Escherichia coli and
Mycobacterium Tuberculosis. D. Clayton, G. Shapovalov, J. A. Maurer, D. A.
Dougherty, H. A. Lester and G. Kochendoerfer, Proc. Natl. Acad. Sci.
(USA), 2004, 101, 4764-4769.
- Investigation of Apparent
Mass Deviations in Electrospray Ionization Tandem Mass Spectrometry of a
Benzophenone Labeled Peptide. J.F. Leite, D.A. Dougherty, H.A. Lester, and
M. Shahgholi, Rapid Comm. Mass Spect., 2003, 17, 1677-1684.
- Identification of Nicotinic
Acetylcholine Receptor a1 Gating-Dependent Molecular Motions Using
Electrophysiology-Coordinated Photochemistry and Mass Spectrometry. J.F.
Leite, M.P. Blanton, M. Shahgholi, D.A. Dougherty, and H.A. Lester, Proc.
Natl. Acad. Sci. USA, 2003, 100, 13054-13059.
- Investigating Lipid
Composition Effects on the Mechanosensitive Channel of Large Conductance
(MscL) Using Molecular Dynamics Simulations. D.E. Elmore and D.A.
Dougherty, Biophysical J., 2003, 85, 1512-1524.
- Unnatural Amino Acid
Mutagenesis in Mapping Ion Channel Function. D.L. Beene, D.A. Dougherty,
and H.A. Lester, Curr. Opin. Neurobiol. 2003, 13,
264-270.
- Site-specific Incorporation
of Unnatural Amino Acids into Receptors Expressed in Mammalian Cells. S.
L. Monahan, H.A. Lester, and D.A. Dougherty, Chem. Biol., 2003,
10, 573-580.
- Different Binding
Orientations for the Same Agonist at Homologous Receptors: A Lock and Key
or a Simple Wedge? T. W. Mu, H. A. Lester, and D. A. Dougherty, J. Am.
Chem. Soc., 2003, 125, 6850-6851.
- Generation and Evaluation of
a Large Mutational Library from the Escherichia coli Mechanosensitive
Channel of Large Conductance, MscL: Implications for Channel Gating and
Evolutionary Design. J.A. Maurer and D.A. Dougherty, J. Biol. Chem.,
2003, 278, 21076-21082.
- Caging Proteins Through
Unnatural Amino Acid Mutagenesis. E. J. Petersson, G. S. Brandt, N. M.
Zacharias, D. A. Dougherty, and H. A. Lester, Methods in Enzymololgy,
2003, 360, 258-73.
- A Perturbed pKa at the
Binding Site of the Nicotinic Acetylcholine Receptor: Implications for
Nicotine Binding. E.J. Petersson, A. Choi, D.S. Dahan, H.A. Lester, and
D.A. Dougherty, J. Am. Chem. Soc., 2002, 124,
12662-12663.
- Cation-pi Interactions in
Ligand Recognition at Serotonergic (5-HT3A) and Nicotine Acetylcholine
Receptors. The Anomalous Binding Properties of Nicotine. D.L. Beene, G.S.
Brandt, W. Zhong, N.M. Zacharias, H.A. Lester, and D.A. Dougherty, Biochemistry,
2002, 41, 10262-10269.
- Cation-pi Interactions in
Ligand Recognition and Catalysis. N. Zacharias and D. A. Dougherty, Trends
Pharmacol. Sci., 2002, 23 (6), 281-287.
- MALDI-TOF Mass Spectrometry
Methods for Evaluation of in vitro Aminoacyl tRNA Production. E.J.
Petersson, M. Shahgholi, H. A. Lester, and D. A. Dougherty, RNA, 2002,
8, 542-547.
- A High-Throughput Screen for
MscL Channel Activity and Mutational Phenotyping. J.A. Maurer and D.A.
Dougherty, Biochim. Biophys. Acta, 2001, 1514,
165-169.
- Incorporation of Caged Cysteine
and Caged Tyrosine into a Transmembrane Segment of the Nicotinic
Acetylcholine Receptor. K.D. Philipson, J.P. Gallivan, G.S. Brandt, D.A.
Dougherty, and H.A. Lester. Am. J. Physiol Cell Physiol, 2001,
281, C195-C206.
- Molecular Dynamics
Simulations of Wild type and Mutant Forms of the M. tuberculosis
MscL Channel. D. E. Elmore and D. A. Dougherty, Biophys. J., 2001,
81, 1345-1359.
- Tyrosine Decaging Leads to
Substantial Membrane Trafficking during Modulation of an Inward Rectifier
Potassium Channel. Y. Tong, G. S. Brandt, M. Li, G. Shapovalov, E. Slimko,
A. Karschin, D. A. Dougherty, and H. A. Lester, J. Gen. Phys., 2001,
117, 103-118.
- The Tethered Agonist Approach
to Mapping Ion Channel Proteins — Toward a Structural Model for the
Agonist Binding Site of Nicotinic Acetylcholine Receptor. L. Li, W. Zhong,
N. Zacharias, C. Gibbs, H. A. Lester, and D. A. Dougherty, Chem. Biol.,
2001, 8, 47-58.
- Comparing and Contrasting Escherichia
coli and Mycobacterium tuberculosis Mechanosensitive Channels
(MscL). New Gain of Function Mutations in the Loop Region. J. A. Maurer,
D. E. Elmore, H. A. Lester, and D. A. Dougherty, J. Biol. Chem., 2000,
275 (29), 22238-22244.
- A Computational Study of
Nicotine Conformations in the Gas Phase and in Water. D. E. Elmore and D.
A. Dougherty, J. Org. Chem., 2000, 65 (3), 742-747.
- Probing the Role of a
Conserved M1 Proline Residue in 5-Hydroxytryptamine3 Receptor Gating. H.
Dong, P.M. England, S.S. Farivar, D.A. Dougherty, and H. A. Lester, Mol.
Pharmacol., 2000, 57, 1114-1122.
- Mapping Disulfide
Connectivity Using Backbone Ester Hydrolysis. P.M. England, H.A. Lester,
and D.A. Dougherty, Biochemistry, 1999, 38,
14409-14415.
- A Computational Study of
Cation-pi Int Interactions vs. Salt Bridges in Aqueous Media: Implications
for Protein Engineering. J.P. Gallivan and D.A. Dougherty, J. Am. Chem.
Soc., 2000, 122 (5), 870-874.
- Cation-pi Interactions in
Structural Biology. J.P. Gallivan and D.A. Dougherty, Proc. Natl. Acad.
Sci. USA, 1999, 96, 9459-9464.
- Incorporation of Esters into
Proteins: Improved Synthesis of Hydroxyacyl tRNAs. P.M. England, H.A.
Lester, D.A. Dougherty, Tetrahedron Lett.,1999, 40,
6189-6192.
- Backbone Mutations in
Transmembrane Domains of a Ligand-Gated Ion Channel: Implications for the
Mechanism of Gating. P. M. England, Y. Zhang, D.A. Dougherty, and H.A.
Lester, Cell, 1999, 96, 89-98.
- A Selective Receptor for
Arginine Derivatives in Aqueous Media. Energetic Consequences of Salt
Bridges that are Highly Exposed to Water. S.M. Ngola, P.C. Kearney, S.
Mecozzi, K. Russell, and D.A. Dougherty, J. Am. Chem. Soc., 1999,
121, 1192-1201.
- From Ab Initio Quantum
Mechanics to Molecular Neurobiology: A Cation-pi Binding Site in the
Nicotinic Receptor. W. Zhong, J.P. Gallivan, Y. Zhang, L. Li, H.A. Lester,
and D.A. Dougherty, Proc. Natl. Acad. Sci. (USA), 1998, 95,
12088-12093.
- Flash Decaging of Tyrosine
Sidechains in an Ion Channel. J. C. Miller, S. K. Silverman, P.M. England,
D.A. Dougherty, and H.A. Lester, Neuron, 1998, 20,
619-624.
- In Vivo Incorporation of
Unnatural Amino Acids into Ion Channels in a Xenopus Oocyte
Expression System. M.W. Nowak, J.P. Gallivan, S.K. Silverman, C.G.
Labarca, D.A. Dougherty, and H.A. Lester, in Methods in Enzymology,
1998, 293, Ion Channels, Part B, E. P. Conn, Ed.,
Academic Press: San Diego, pp. 504-529.
- Site-Specific Incorporation
of Biotinylated Amino Acids as a Means to Identify Surface Exposed
Residues in Integral Membrane Proteins. J.P. Gallivan, H.A. Lester, and
D.A. Dougherty, Chem. Biol., 1997, 4, 739-749.
- Is the Brain Ready for
Physical Organic Chemistry? D.A. Dougherty, J. Phys. Org. Chem., 1998,
11, 334-340.
- Site-Specific, Photochemical
Proteolysis Applied to Ion Channels In Vivo. P.M. England, H.A. Lester, N.
Davidson, and D. A. Dougherty, Proc. Natl. Acad. Sci. (USA), 1997,
94, 11025-11030.
- The Cation-pi Interaction.
J.C. Ma and D.A. Dougherty, Chem. Rev., 1997, 97,
1303-1324.
- Determinants of Nicotinic
Receptor Gating in Natural and Unnatural Side Chain Structures at the M2
9’ Position. P.C. Kearney, H. Zhang, W. Zhong, D.A. Dougherty, and H.A.
Lester, Neuron, 1996,17, 1221-1229.
- Cation-pi Interactions in
Aromatics of Biological and Medicinal Interest: Electrostatic Potential
Surfaces as a Useful Qualitative Guide. S. Mecozzi, A.P. West, Jr., and
D.A. Dougherty, Proc. Natl. Acad. Sci. USA, 1996, 93,
10566-10571.
- Evidence for the Importance
of Polarizability in Biomimetic Catalysis Involving Cyclophane Receptors.
S.M. Ngola and D. A. Dougherty, J. Org. Chem., 1996, 61,
4355-4360.
- Cation-pi Interactions in
Simple Aromatics. Electrostatics Provide a Predictive Tool. S. Mecozzi,
A.P. West, Jr., and D.A. Dougherty, J. Am. Chem. Soc., 1996,
118, 2307-2308.
- Cation-pi Interactions in
Chemistry and Biology. A New View of Benzene, Phe, Tyr, and Trp. D.A.
Dougherty, Science, 1996, 271, 163-168.
- Nicotinic Receptor Binding
Site Probed with Unnatural Amino-Acid Incorporation in Intact Cells. M.W.
Nowak, P.C. Kearney, J.R. Sampson, M.E. Saks, C.G. Labarca, S.K.
Silverman, W. Zhong, J. Thorson, J.N. Abelson, N. Davidson, P.G. Schultz,
D.A. Dougherty, and H.A. Lester, Science, 1995, 268,
439-442.