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Selected Publications:

  • Photoactivation of an Acid-Sensitive Ion Channel Associated with Vision and Pain, O.S. Shafaat, J.R. Winkler, H.B. Gray, D.A. Dougherty, ChemBioChem, 2016, 17, 1323-1327
  • Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity alpha 4 beta 2, and Increases alpha 5 alpha 4 beta 2, Nicotinic Receptor Surface Expression, W.A. Nichols, B.J. Henderson, C.B. Marotta, C.Y. Yu, C. Richards, D.A. Dougherty, H.A. Lester, and B.N. Cohen, PLOS ONE, 2016, 11, e0158032
  • Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports Conserved Gating Motions among Cys-loop Receptors. M. Rienzo, A.R. Rocchi, S.D. Threatt, D.A. Dougherty, S.C. Lummis, J Biol Chem., 2016, 12, 6272-80.
  • Caton-pi interactions: computational analyses of the aromatic box motif and the fluorination strategy for experimental evaluation. M.R. Davis, D.A. Dougherty, Phys Chem Chem Phys., 2015, 43, 29262-70.
  • An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors. C.B. Marotta, H.A. Lester, D.A. Dougherty, Chem Biol., 2015, 8, 1063-73.
  • Ketamine inside neurons? H.A. Lester, L.D. Lavis, D.A. Dougherty, Am J Psychiatry, 2015, 11, 1064-6.
  • Heterologous Expression and Nonsense Suppression Probe Agonist Behaviors at α6β2 Nicotinic Receptors, M.R Post, W. Limapichat, H. A Lester, D. A Dougherty, Neuropharm., 2015, 97, 376-382.
  • The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors, J.S. Wieskopf, J. Mathur, W. Limapichat, M.R. Post, M. Al-Qazzaz, R.E. Sorge, L.J. Martin, D.V. Zaykin, S.B. Smith, K. Freitas, J-S Austin, F. Dai, J. Zhang, J. Marcovitz, A.H. Tuttle, P.M. Slepian, S. Clarke, R.M. Drenan, J. Janes, S. Al Sharari, S.K. Segall, E.K. Aasvang, W. Lai, R. Bittner, C.I. Richards, G.D. Slade, H. Kehlet, J. Walker, U. Maskos, J-P. Changeux, M. Devor, W. Maixner, L. Diatchenko, I. Belfer, D.A. Dougherty, A.I. Su, S.C.R. Lummis, M.I. Damaj, H.A. Lester, A. Patapoutian, J.S. Mogil, Sci Transl Med , 2015, 7, 287ra72.
  • Allosteric activation of the 5-HT3AB receptor by mCPBG, T.F. Miles, H.A. Lester, D.A. Dougherty, Neuropharm., 2015, 97, 103-108; PMCID:PMC4312754
  • Structural Requirements in the Transmembrane Domain of GLIC Revealed by Incorporation of Noncanonical Histidine Analogs, M. Rienzo, S.C. Lummis, D.A. Dougherty, ACS Chem Biol., 2014, 21, 1700-6.
  • Functional Evaluation of Key Interactions Evident in the Structure of the Eukaryotic Cys-Loop Receptor GluCl, K.N. Daeffler, H.A. Lester, D.A. Dougherty, ACS Chem Biol., 2014, 9, 2283-90.
  • In vivo incorporation of non-canonical amino acids by using the chemical aminoacylation strategy: a broadly applicable mechanistic tool, D.A. Dougherty, E.B. Van Arnam, Chembiochem., 2014, 15, 1710-20.
  • Subtype-specific mechanisms for functional interaction between α6β4* nicotinic acetylcholine receptors and P2X receptors, W. Limapichat, D.A. Dougherty, H.A. Lester, Mol Pharmacol., 2014, 86, 263-74. DOI: 10.1124/mol.114.093179
  • Functional probes of drug-receptor interactions implicated by structural studies: Cys-loop receptors provide a fertile testing ground, E.B. Van Arnam, D.A. Dougherty, J Med Chem., 2014, 57, 6289-300.
  • Selective ligand behaviors provide new insights into agonist activation of nicotinic acetylcholine receptors, C.B. Marotta, I. Rreza, H.A. Lester, D.A. Dougherty, ACS Chem Biol., 2014, 9, 1153-9.
  • Probing the Non-Canonical Interface for Agonist Interaction with an α5 Containing Nicotinic Acetylcholine Receptor, C.B. Marotta, C.N. Dilworth, H.A. Lester, D.A. Dougherty, Neuropharm., 2013, 77, 342-349.
  • The 5-HT3AB receptor shows an A3B2 stoichiometry at the plasma membrane, T. F. Miles, D. A. Dougherty, and H. A. Lester, Biophys. J., 2013, 105, 887-898.
  • An unusual pattern of ligand-receptor interactions for the α7 nicotinic acetylcholine receptor, with implications for the binding of varenicline, E. B. Van Arnam, E. E. Blythe, H. A. Lester, and D. A. Dougherty, Mol. Pharm., 2013, 84, 201-207. PMCID:PMC3716316
  • Binding Interactions To The Complementary Subunit Of Nicotinic Receptors A. P. Blum, E. B. Van Arnam, L. A. German, H. A. Lester, and D. A. Dougherty, J. Biol. Chem., 2013, 288, 6991-6997. PMCID: PMC3591609
  • The Cation-π Interaction, D.A. Dougherty, Accts. Chem. Res., 2013, 46, 885-893.
  • Key Binding Interactions for Memantine in the NMDA Receptor, W. Limapichat, W. Yu, E. Branigan, H. A. Lester, D. A. Dougherty, ACS Chem. Neurosci., 2013, 4, 255-260.
  • GABA Binding to an Insect GABA Receptor: A Molecular Dynamics and Mutagenesis Study, J. A. Ashby, I. V. McGonigle, K. L. Price, N. Cohen, F. Comatini, D. A. Dougherty, C. Molteni, S. C. R. Lummis, Biophys. J., 2012, 103, 2071-2081. PMCID: PMC3512037
  • Forster Resonance Energy Transfer (FRET) correlates of altered subunit stoichiometry in Cys-loop receptors, exemplified by nicotinic α4β2 R. Srinivasan, C. I. Richards, C. Dilworth, F. J. Moss, D. A. Dougherty, and H. A. Lester, Int. J. Mol. Sci., 2012, 13, 10022-10040. PMCID: PMC3431844
  • Live-Cell Imaging of Single Receptor Composition Using Zero-Mode Waveguide Nanostructures, C. Richards, K. Luong, R. Srinivasan, S. Turner, D. A. Dougherty, H. A. Lester, Nano Lett., 2012, 12, 3690-3694. PMCID: PMC3397148
  • Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines, D. Bertrand, H. Nury, S. Lummis, D. A. Dougherty, M. Veheij, P. Legrand, J. Ramerstorfer, R. Spurny, Proc. Natl. Acad. Sci., 2012, 109, E3028-E3034. PMCID:PMC3497736
  • Functionally Important Aromatic-Aromatic and Sulfur-π Interactions in the D2 Dopamine Receptor, K. N. M. Daeffler, H. A. Lester, D. A. Dougherty, J. Am. Chem. Soc., 2012, 134, 14890-14896. PMCID: PMC3461201
  • Ondansetron and Granisetron Binding Orientation in the 5-HT3 Receptor Determined by Unnatural Amino Acid Mutagenesis, N. H. Duffy, H. A. Lester, D. A. Dougherty, ACS Chem. Biol., 2012, 7, 1738-1745. DOI: 10.1021/cb300246j. PMCID: PMC:3477246
  • A Coupled Array Of Noncovalent Interactions Impacts The Function Of The 5-HT3A Serotonin Receptor In An Agonist-Specific Way, T. F. Miles, K. S. Bower, H. A. Lester, D. A. Dougherty, ACS Chem. Neurosci., 2012, 3, 753-760. DOI: 10.1021/cn3000586. PMCID: PMC3474281
  • Variations in Binding Among Several Agonists at Two Stoichiometries of the Neuronal, α4β2 Nicotinic Receptor, X. Da Silva Tavares, A. P. Blum, D. T. Nakamura, N. L. Puskar, J. A. P. Shanata, H. A. Lester, D. A. Dougherty, J. Am Chem. Soc., 2012, 134, 11474-11480. PMCID: PMC3399941
  • Pharmacological Chaperoning of Nicotinic Acetylcholine Receptors Reduces the ER Stress Response. R. Srinivasan, C. I. Richards, D. Rhee, R. Pantoja, D. A. Dougherty, J. M. Miwa, H. A. Lester, Mol. Pharmacol., 2012, 81, 759-769. PMCID: PMC3362896
  • Probing the Effects of Residues Located Outside the Agonist Binding Site on Drug-Receptor Selectivity in the Nicotinic Receptor, N. L. Puskar, H. A. Lester, D. A. Dougherty, ACS Chem. Biol., 2012, 7, 841-846. PMCID: PMC3356501
  • Multiple Tyrosine Residues Contribute To GABA Binding In The GABAC Receptor Binding Pocket, S. C. R. Lummis., N. J Harrison, J. Wang, J. A. Ashby, K. S. Millen, D. L. Beene and D. A. Dougherty, ACS Chem. Neurosci., 2012, 3 (3), 186-192. PMCID: PMC3309607
  • Using Mutant Cycle Analysis to Elucidate Long-Range Functional Coupling in Allosteric Receptors, J. A. P. Shanata, S. J. Frazier, H. A. Lester, and D.A. Dougherty, in Allostery, Methods and Protocols, A. W. Fenton, Ed., 2012, Springer, New York, pp 97-113. doi: 10.1007/978-1-61779-334-9_6.
  • Dissecting the functions of conserved prolines within transmembrane helices of the D2 dopamine receptor, E. B. Van Arnam, H. A. Lester, D. A. Dougherty, ACS Chem. Biol., 2011, 6, 1063-1068. PMCID: PMC3199346
  • Evidence for an Extended Hydrogen Bond Network in the Binding Site of the Nicotinic Receptor: Concerning the Role of the Vicinal Disulfide of the α1 Subunit, A. P. Blum, K. R. Gleitsman, H. A. Lester, and D. A. Dougherty, J. Biol. Chem., 2011, 286, 32251-32258. PMCID: PMC3173184
  • Two amino acid residues contribute to a Cation-π Binding Interaction in the Binding Site of an insect GABA receptor, S.C.R. Lummis, I. McGonigle, J.A. Ashby and D.A. Dougherty, J. Neurosci., 2011, 31, 12371-12376. PMCID: PMC3233689
  • Two Neuronal Nicotinic Acetylcholine Receptors – α4β4 and α7 – Show Differential Ligand Binding Modes, N.L. Puskar, X. Xiu, H.A. Lester, D.A. Dougherty, J. Biol. Chem., 2011, 286, 14618-14627. PMCID PMC3077659
  • A Cation-π Interaction at a Phenylalanine Residue in the Glycine Receptor Binding Site is Conserved for Different Agonists, S.A. Pless, A.P. Hanek, K.L. Price, J.W. Lynch, H.A. Lester, D.A. Dougherty, and S.C.R. Lummis, Mol. Pharm., 2011, 79, 742-748. PMCID PMC3063724
  • A Room-Temperature Alternative to the Arbuzov Reaction: the Reductive Deoxygenation of Acyl Phosphonates, S.M.A. Kedrowski, D.A. Dougherty, Org. Lett., 2010, 12, 3990-3993. PMCID: PMC2941390
  • Preparation of Translationally Competent tRNA by Direct Chemical Acylation, N.H. Duffy, D.A. Dougherty, Org. Lett.,2010, 12, 3776-3779. PMCID: PMC2929286
  • The nicotinic pharmacophore: The polar groups of ACh and nicotine hydrogen bond across a subunit interface to a backbone NH, A. P. Blum, H. A. Lester, D. A. Dougherty, Proc. Natl. Acad. Sci., 2010, 107, 13206-13211.
  • A Gating Charge Transfer Center in Voltage Sensors X. Tao, A. L. MacKinnon, W. Limapichat, D. A. Dougherty, R. MacKinnon,*, Science, 2010, 328, 67-73.
  • Chemical-Scale Studies of the Phe-Pro Conserved Motif in the Cys-loop of Cys-loop Receptors, W. Limapichat, H.A. Lester, D.A. Dougherty, J. Biol. Chem., 2010, 285, 8976-8984.
  • Photochemical Proteolysis of an Unstructured Linker of the GABAAR Extracellular Domain prevents GABA but not Pentobarbital Activation, A.P. Hanek, H.A. Lester, D.A. Dougherty, Mol. Pharm. 2010, 78, 29-35.
  • Nicotine Binding to Brain Receptors Requires a Strong Cation-π Interaction X. Xiu*, N.L. Puskar*, J.A.P. Shanata, H.A. Lester, and D.A. Dougherty, Nature, 2009, 458, 534-537.
  • An Electrostatic Interaction between TEA and an Introduced Pore Aromatic drives Spring-in-the-Door Inactivation in Shaker Potassium Channels, C.A. Ahern, A.L. Eastwood, D.A. Dougherty, R. Horn, J. Gen. Phys. 2009, 134, 461-469.
  • Probing the Role of the Cation-π Interaction in the Binding Sites of GPCRs Using Unnatural Amino Acids, M.M. Torrice, K.S. Bower, H.A. Lester, D.A. Dougherty, Proc. Natl. Acad. Sci., 2009, 106, 11919-11924.
  • Probing the Role of Backbone Hydrogen Bonding in a Critical β-sheet of the Extracellular Domain of a Cys-loop Receptor, K.R. Gleitsman, H.A. Lester, D.A. Dougherty, ChemBioChem, 2009, 10, 1385-1391.
  • Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery, H.A. Lester, C. Xiao, R. Srinivasan, C. Son, J. Miwa, R. Pantoja, D.A. Dougherty, M. R. Banghart, A. M. Goate, J. C. Wang, and L. J. Bierut, AAPS Journal, 2009, 11, 167-177.
  • A Selenide-Based Approach to Photochemical Cleavage of Peptide and Protein Backbones at Engineered Backbone Esters, A.L. Eastwood*, A.P. Blum*, N.M. Zacharias, D.A. Dougherty, J. Org.Chem., 2009, 74, 9241-9244.
  • An Intersubunit Hydrogen Bond in the Nicotinic Acetylcholine Receptor that Contributes to Channel Gating, K.R. Gleitsman*, S.M.A. Kedrowski*, H.A. Lester and D.A. Dougherty, J. Biol. Chem, 2008, 283, 35638-35643.
  • Long-Range Coupling in an Allosteric Receptor Reveals a Residue’s Function, K.R. Gleitsman*, J.A.P. Shanata*, S.J. Frazier, H.A. Lester, and D.A. Dougherty, Biophys.J., 2009, 96, 3168-3178.
  • A Cation-π Interaction in The Binding Site of The Glycine Receptor Mediated by a Phenylalanine Residue, S.A. Pless, K.S. Millen, A.P. Hanek, J.W. Lynch, H.A. Lester, S.C.R. Lummis, and D.A. Dougherty, J. Neurosci., 2008, 28, 10937-10942.
  • Single-molecule Imaging of a Fluorescent Unnatural Amino Acid Incorporated into Functional Nicotinic Acetylcholine Receptors, R. Pantoja, E. A. Rodriguez, M.I. Dibas, D.A. Dougherty, and H.A. Lester Biophys. J., 2009, 96, 226-237.
  • Long-Range Coupling in an Allosteric Receptor Reveals a Residue’s Function, K. R. Gleitsman*, J. A. P. Shanata*, S. J. Frazier, H. A. Lester, and D. A. Dougherty, Biophys.J., 2009, 96, 3168-3178.
  • A Stereochemical Test of a Proposed Mechanism for Nicotinic Receptor Gating, A. P. Hanek, H. A. Lester and D. A. Dougherty, J. Am. Chem. Soc., 2008, 130, 13216-13218.
  • An Intersubunit Hydrogen Bond in the Nicotinic Acetylcholine Receptor that Contributes to Channel Gating, K.R. Gleitsman*, S.M.A. Kedrowski*, H.A. Lester and D.A. Dougherty, J. Biol. Chem, 2008, 283, 35638-35643.
  • A hydrogen bond in Loop A is critical for binding and function of the 5-HT3 receptor. K. L. Price, K.S. Bower, A.J. Thompson, H.A. Lester, D.A. Dougherty, and S.C.R. Lummis, Biochemistry, 2008, 47, 6370-6377.
  • Physical Organic Chemistry on the Brain, D.A. Dougherty, J. Org. Chem. 2008, 73, 3667-3673.
  • Cys-loop Neuroreceptors: Structure to the Rescue?, D.A. Dougherty, Chem. Rev., 2008, 108, 1642-1653.
  • Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-gated Sodium Channels, C.A. Ahern, A.L. Eastwood, D.A. Dougherty, and R. Horn, Circulation Res., 2008, 102, 86-94.
  • Confirming the Revised C-terminal Domain of the MscL Crystal Structure, J.A. Maurer, D.E. Elmore, D. Clayton, H.A. Lester, D.A. Dougherty, Biophys.J., 2008, 94, 4662–4667.
  • Improved Amber and Opal Suppressor tRNAs for Incorporation of Unnatural Amino Acids In Vivo, Part 2: Evaluating Suppression Efficiency, E. A. Rodriguez, H. A. Lester, D. A. Dougherty, RNA, 2007, 13, 1715-1722.
  • Improved Amber and Opal Suppressor tRNAs for Incorporation of Unnatural Amino Acids In Vivo, Part 1: Minimizing Misacylation, E. A. Rodriguez, H. A. Lester, D. A. Dougherty, RNA, 2007, 13, 1703-1714.
  • 1-Oxo-5-hydroxytryptamine: A Surprisingly Potent Agonist of the 5-HT3 (Serotonin) Receptor. S.M.A. Kedrowski, K.S. Bower, D.A. Dougherty, Org. Lett., 2007, 9, 3205-3207.
  • 5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function. K.S. Bower, K.L.Price, L.E. Sturdee, D.A. Dougherty, S.C.R. Lummis, Eur. J. Pharm., 2008, 580, 291-297.
  • Reconstitution of Ion Channels in Agarose-Supported Silicon Orifices, J.A. Maurer, V.E. White, D.A. Dougherty, J.L. Nadeau, Biosensors Bioelectronics, 2007, 22, 2577-2584.
  • Calcium Block of Single Sodium Channels. Role of a Pore-lining Aromatic Residue, V.P. Santarelli, A.L. Eastwood, D.A. Dougherty, C.A. Ahern, R. Horn, Biophys. J., 2007, 93, 2341-2349.
  • Establishing an Ion Pair in the GABAC Receptor that Contributes to the Gating Pathway, J. Wang, H.A. Lester, D.A. Dougherty, J. Biol. Chem., 2007, 282, 26210-26216.
  • A Cation-π Interaction Discriminates Among Sodium Channels that are either Sensitive or Resistant to Tetrodotoxin Block, V.P. Santarelli, A.L. Eastwood, D.A. Dougherty, R. Horn, C.A. Ahern, J. Biol. Chem., 2007, 282, 8044-8051.
  • Chemical-Scale Studies on the Role of a Conserved Aspartate in Preorganizing the Agonist Binding Site of the Nicotinic Acetylcholine Receptor. A.L. Cashin, M.M. Torrice, K.A. McMenimen, H.A. Lester, D.A. Dougherty, Biochemistry, 2007, 46, 630-639.
  • Unnatural Amino Acid Mutagenesis of the GABAA Receptor Binding Site Residues Reveals a Novel Cation-π Interaction Between GABA and b2 Tyr97. Padgett C.L., Hanek A.P., Lester H.A., Dougherty D.A. and Lummis S.C.R., J. Neurosci., 2007, 27, 886-892.
  • A Cation-π Interaction between Extracellular TEA and an Aromatic Residue in Potassium Channels, C.A. Ahern, A.L. Eastwood, H.A. Lester and D.A. Dougherty and R. Horn, J. Gen. Phys. 2006, 128, 649-657.
  • Probing the Mg2+ Blockade Site of an NMDA Receptor with Unnatural Amino Acid Mutagenesis, K.A. McMenimen, E.J. Petersson, H.A. Lester, D.A. Dougherty, ACS Chem. Biol., 2006, 1, 227-234.
  • Voltage-Dependent Hydration and Conduction Properties of the Hydrophobic Pore of the MscS Channel. S.A. Spronk, D.E. Elmore, D.A. Dougherty, Biophys. J., 2006, 90, 3555-3569.
  • In Vivo Incorporation of Multiple Unnatural Amino Acids Using Nonsense and Frameshift Suppression. E. A. Rodriguez, H. A. Lester, and D. A. Dougherty, Proc. Natl. Acad. Sci. (USA), 2006, 103, 8650-8655.
  • A Unified View of the Role of Electrostatic Interactions in Modulating the Gating of Cys Loop Receptors. X. Xiu, A.P. Hanek, J. Wang, H.A. Lester, and D.A. Dougherty, J. Biol. Chem., 2005, 280, 41655-41666.
  • A Cation-pi Binding Interaction with a Tyrosine in the Binding Site of the GABAC Receptor. S.C.R. Lummis, D.L. Beene, N.J. Harrison, H.A. Lester, and D.A. Dougherty, Chem. Biol. 2005, 12, 993-997.
  • Cis-trans Isomerization at a Proline Opens the Pore of a Neurotransmitter-gated Ion Channel. S.C.R. Lummis, D.L. Beene, L.W. Lee, H.A. Lester, R. William Broadhurst, and D.A. Dougherty, Nature, 2005, 438, 248-252.
  • Caged Phosphoproteins. D.M. Rothman, E.J. Petersson, M.E. Vázquez, G.S. Brandt, D.A. Dougherty*, B. Imperiali* J. Am. Chem. Soc., 2005, 127, 846-847.
  • Using Physical Chemistry to Differentiate Nicotinic from Cholinergic Agonists at the Nicotinic Acetylcholine Receptor. A.L. Cashin, E.J. Petersson, H.A. Lester, and D.A. Dougherty J. Am. Chem. Soc., 2005, 127, 350-356.
  • Cys-loop Receptors: New Twists and Turns H.A. Lester, M.I. Dibas, D.S. Dahan, J.F. Leite, and D.A. Dougherty Trends Neurosci., 2004, 27, 329-336.
  • Tyrosine Residues That Control Binding and Gating in the 5-Hydroxytryptamine3 Receptor Revealed by Unnatural Amino Acid Mutagenesis. D.L. Beene, K.L. Price, H.A. Lester, D.A. Dougherty, and S.C.R. Lummis, J. Neurosci., 2004, 24, 9097-9104.
  • A fluorophore attached to nicotinic acetylcholine receptor bM2 detects productive binding of agonist to the ad site. D.S. Dahan, V.A. Auyeung, D.A. Dougherty, and H.A. Lester, Proc. Natl. Acad. Sci. (USA), 2004, 101, 10195-10200.
  • Total chemical synthesis, vesicle-reconstitution and electrophysiological characterization of the mechanosensitive channels of large conductance from Escherichia coli and Mycobacterium Tuberculosis. D. Clayton, G. Shapovalov, J. A. Maurer, D. A. Dougherty, H. A. Lester and G. Kochendoerfer, Proc. Natl. Acad. Sci. (USA), 2004, 101, 4764-4769.
  • Investigation of Apparent Mass Deviations in Electrospray Ionization Tandem Mass Spectrometry of a Benzophenone Labeled Peptide. J.F. Leite, D.A. Dougherty, H.A. Lester, and M. Shahgholi, Rapid Comm. Mass Spect., 2003, 17, 1677-1684.
  • Identification of Nicotinic Acetylcholine Receptor a1 Gating-Dependent Molecular Motions Using Electrophysiology-Coordinated Photochemistry and Mass Spectrometry. J.F. Leite, M.P. Blanton, M. Shahgholi, D.A. Dougherty, and H.A. Lester, Proc. Natl. Acad. Sci. USA, 2003, 100, 13054-13059.
  • Investigating Lipid Composition Effects on the Mechanosensitive Channel of Large Conductance (MscL) Using Molecular Dynamics Simulations. D.E. Elmore and D.A. Dougherty, Biophysical J., 2003, 85, 1512-1524.
  • Unnatural Amino Acid Mutagenesis in Mapping Ion Channel Function. D.L. Beene, D.A. Dougherty, and H.A. Lester, Curr. Opin. Neurobiol. 2003, 13, 264-270.
  • Site-specific Incorporation of Unnatural Amino Acids into Receptors Expressed in Mammalian Cells. S. L. Monahan, H.A. Lester, and D.A. Dougherty, Chem. Biol., 2003, 10, 573-580.
  • Different Binding Orientations for the Same Agonist at Homologous Receptors: A Lock and Key or a Simple Wedge? T. W. Mu, H. A. Lester, and D. A. Dougherty, J. Am. Chem. Soc., 2003, 125, 6850-6851.
  • Generation and Evaluation of a Large Mutational Library from the Escherichia coli Mechanosensitive Channel of Large Conductance, MscL: Implications for Channel Gating and Evolutionary Design. J.A. Maurer and D.A. Dougherty, J. Biol. Chem., 2003, 278, 21076-21082.
  • Caging Proteins Through Unnatural Amino Acid Mutagenesis. E. J. Petersson, G. S. Brandt, N. M. Zacharias, D. A. Dougherty, and H. A. Lester, Methods in Enzymololgy, 2003, 360, 258-73.
  • A Perturbed pKa at the Binding Site of the Nicotinic Acetylcholine Receptor: Implications for Nicotine Binding. E.J. Petersson, A. Choi, D.S. Dahan, H.A. Lester, and D.A. Dougherty, J. Am. Chem. Soc., 2002, 124, 12662-12663.
  • Cation-pi Interactions in Ligand Recognition at Serotonergic (5-HT3A) and Nicotine Acetylcholine Receptors. The Anomalous Binding Properties of Nicotine. D.L. Beene, G.S. Brandt, W. Zhong, N.M. Zacharias, H.A. Lester, and D.A. Dougherty, Biochemistry, 2002, 41, 10262-10269.
  • Cation-pi Interactions in Ligand Recognition and Catalysis. N. Zacharias and D. A. Dougherty, Trends Pharmacol. Sci., 2002, 23 (6), 281-287.
  • MALDI-TOF Mass Spectrometry Methods for Evaluation of in vitro Aminoacyl tRNA Production. E.J. Petersson, M. Shahgholi, H. A. Lester, and D. A. Dougherty, RNA, 2002, 8, 542-547.
  • A High-Throughput Screen for MscL Channel Activity and Mutational Phenotyping. J.A. Maurer and D.A. Dougherty, Biochim. Biophys. Acta, 2001, 1514, 165-169.
  • Incorporation of Caged Cysteine and Caged Tyrosine into a Transmembrane Segment of the Nicotinic Acetylcholine Receptor. K.D. Philipson, J.P. Gallivan, G.S. Brandt, D.A. Dougherty, and H.A. Lester. Am. J. Physiol Cell Physiol, 2001, 281, C195-C206.
  • Molecular Dynamics Simulations of Wild type and Mutant Forms of the M. tuberculosis MscL Channel. D. E. Elmore and D. A. Dougherty, Biophys. J., 2001, 81, 1345-1359.
  • Tyrosine Decaging Leads to Substantial Membrane Trafficking during Modulation of an Inward Rectifier Potassium Channel. Y. Tong, G. S. Brandt, M. Li, G. Shapovalov, E. Slimko, A. Karschin, D. A. Dougherty, and H. A. Lester, J. Gen. Phys., 2001, 117, 103-118.
  • The Tethered Agonist Approach to Mapping Ion Channel Proteins — Toward a Structural Model for the Agonist Binding Site of Nicotinic Acetylcholine Receptor. L. Li, W. Zhong, N. Zacharias, C. Gibbs, H. A. Lester, and D. A. Dougherty, Chem. Biol., 2001, 8, 47-58.
  • Comparing and Contrasting Escherichia coli and Mycobacterium tuberculosis Mechanosensitive Channels (MscL). New Gain of Function Mutations in the Loop Region. J. A. Maurer, D. E. Elmore, H. A. Lester, and D. A. Dougherty, J. Biol. Chem., 2000, 275 (29), 22238-22244.
  • A Computational Study of Nicotine Conformations in the Gas Phase and in Water. D. E. Elmore and D. A. Dougherty, J. Org. Chem., 2000, 65 (3), 742-747.
  • Probing the Role of a Conserved M1 Proline Residue in 5-Hydroxytryptamine3 Receptor Gating. H. Dong, P.M. England, S.S. Farivar, D.A. Dougherty, and H. A. Lester, Mol. Pharmacol., 2000, 57, 1114-1122.
  • Mapping Disulfide Connectivity Using Backbone Ester Hydrolysis. P.M. England, H.A. Lester, and D.A. Dougherty, Biochemistry, 1999, 38, 14409-14415.
  • A Computational Study of Cation-pi Int Interactions vs. Salt Bridges in Aqueous Media: Implications for Protein Engineering. J.P. Gallivan and D.A. Dougherty, J. Am. Chem. Soc., 2000, 122 (5), 870-874.
  • Cation-pi Interactions in Structural Biology. J.P. Gallivan and D.A. Dougherty, Proc. Natl. Acad. Sci. USA, 1999, 96, 9459-9464.
  • Incorporation of Esters into Proteins: Improved Synthesis of Hydroxyacyl tRNAs. P.M. England, H.A. Lester, D.A. Dougherty, Tetrahedron Lett.,1999, 40, 6189-6192.
  • Backbone Mutations in Transmembrane Domains of a Ligand-Gated Ion Channel: Implications for the Mechanism of Gating. P. M. England, Y. Zhang, D.A. Dougherty, and H.A. Lester, Cell, 1999, 96, 89-98.
  • A Selective Receptor for Arginine Derivatives in Aqueous Media. Energetic Consequences of Salt Bridges that are Highly Exposed to Water. S.M. Ngola, P.C. Kearney, S. Mecozzi, K. Russell, and D.A. Dougherty, J. Am. Chem. Soc., 1999, 121, 1192-1201.
  • From Ab Initio Quantum Mechanics to Molecular Neurobiology: A Cation-pi Binding Site in the Nicotinic Receptor. W. Zhong, J.P. Gallivan, Y. Zhang, L. Li, H.A. Lester, and D.A. Dougherty, Proc. Natl. Acad. Sci. (USA), 1998, 95, 12088-12093.
  • Flash Decaging of Tyrosine Sidechains in an Ion Channel. J. C. Miller, S. K. Silverman, P.M. England, D.A. Dougherty, and H.A. Lester, Neuron, 1998, 20, 619-624.
  • In Vivo Incorporation of Unnatural Amino Acids into Ion Channels in a Xenopus Oocyte Expression System. M.W. Nowak, J.P. Gallivan, S.K. Silverman, C.G. Labarca, D.A. Dougherty, and H.A. Lester, in Methods in Enzymology, 1998, 293, Ion Channels, Part B, E. P. Conn, Ed., Academic Press: San Diego, pp. 504-529.
  • Site-Specific Incorporation of Biotinylated Amino Acids as a Means to Identify Surface Exposed Residues in Integral Membrane Proteins. J.P. Gallivan, H.A. Lester, and D.A. Dougherty, Chem. Biol., 1997, 4, 739-749.
  • Is the Brain Ready for Physical Organic Chemistry? D.A. Dougherty, J. Phys. Org. Chem., 1998, 11, 334-340.
  • Site-Specific, Photochemical Proteolysis Applied to Ion Channels In Vivo. P.M. England, H.A. Lester, N. Davidson, and D. A. Dougherty, Proc. Natl. Acad. Sci. (USA), 1997, 94, 11025-11030.
  • The Cation-pi Interaction. J.C. Ma and D.A. Dougherty, Chem. Rev., 1997, 97, 1303-1324.
  • Determinants of Nicotinic Receptor Gating in Natural and Unnatural Side Chain Structures at the M2 9’ Position. P.C. Kearney, H. Zhang, W. Zhong, D.A. Dougherty, and H.A. Lester, Neuron, 1996,17, 1221-1229.
  • Cation-pi Interactions in Aromatics of Biological and Medicinal Interest: Electrostatic Potential Surfaces as a Useful Qualitative Guide. S. Mecozzi, A.P. West, Jr., and D.A. Dougherty, Proc. Natl. Acad. Sci. USA, 1996, 93, 10566-10571.
  • Evidence for the Importance of Polarizability in Biomimetic Catalysis Involving Cyclophane Receptors. S.M. Ngola and D. A. Dougherty, J. Org. Chem., 1996, 61, 4355-4360.
  • Cation-pi Interactions in Simple Aromatics. Electrostatics Provide a Predictive Tool. S. Mecozzi, A.P. West, Jr., and D.A. Dougherty, J. Am. Chem. Soc., 1996, 118, 2307-2308.
  • Cation-pi Interactions in Chemistry and Biology. A New View of Benzene, Phe, Tyr, and Trp. D.A. Dougherty, Science, 1996, 271, 163-168.
  • Nicotinic Receptor Binding Site Probed with Unnatural Amino-Acid Incorporation in Intact Cells. M.W. Nowak, P.C. Kearney, J.R. Sampson, M.E. Saks, C.G. Labarca, S.K. Silverman, W. Zhong, J. Thorson, J.N. Abelson, N. Davidson, P.G. Schultz, D.A. Dougherty, and H.A. Lester, Science, 1995, 268, 439-442.