The next offering of Bi 145 will be in fall term, 1998-99. The format will be basically similar to the 1997 offering, but it will not assume that students have taken Bi 11.
Bi/Ch 110 and Bi 150 will make the course easier, but are not required prerequisites.
Texts for the course will be: "Eckert Animal Physiology", Randall et al., 1996, and "The Pathway for Oxygen", Weibel, 1984.
As in past years, grading will be primarily based on completion of problem sets.
Bi 145 Animal Physiology 1998 Preliminary outline of lectures
wk 1) (Sept. 29, Oct. 1) Introduction: common molecular components.
Physiology of spermatozoa -- respiration, energetics and ~P transport.
Muscle: basic ideas, using frog fast twitch muscle as example
wk 2) (Oct. 6,8) Activation of contraction in fast twitch muscle. Excitation-contraction
coupling in skeletal muscle.
Thermodynamic constraints and models of muscle cross-bridge behavior;
Specialization of striated muscle: comparison of slow and fast fibers; efficiency;
sarcomere length specialization.
wk 3) (Oct. 13,15) Oscillatory properties: insect fibrillar muscle
Problems of stability in multisarcomere systems
wk 4) (Oct. 20,22) Cardiac muscle; energetics and overview.
Channels of cardiac muscle cells; origin of cardiac rhythmicity;
and some pharmacology
wk 5) (Oct 27,29) .Regulation of cardiac muscle contractility.
Introduction to "Smooth" muscle
neural and hormonal controls of gastrointestinal tract
wk 6) (Nov. 3,5) Oxygen transport by the mammalian circulatory system. Overview
and energetics. Microcirculation and local
controls. Design of distribution systems: arteries and airways.
wk 7) (Nov. 10,12)
Energetics of respiration: resistance and surface tension.
Control of respiration.
Physiology of mammalian erythrocytes. Cell volume regulatory
wk 8) (Nov. 17,19)
Epithelial transport: Frog skin transport as a historical item and introduction.
Membrane channels and transport systems of epithelial cells.
Chloride channels and secretory epithelia.
The mammalian kidney and other excretory systems
wk 9) (Nov. 24) Epithelial transport in mammalian kidney
wk 10) (Dec. 1,3)
Regulation of body fluid volume and composition.
Global controls and the response to exercise and other stresses.
Last update 5/22/98