LOCUS       NP_056888                526 aa            linear   VRL 08-DEC-2008
DEFINITION  p60 src [Rous sarcoma virus].
ACCESSION   NP_056888
VERSION     NP_056888.1  GI:9626200
DBSOURCE    REFSEQ: accession NC_001407.1
KEYWORDS    .
SOURCE      Rous sarcoma virus
  ORGANISM  Rous sarcoma virus
            Viruses; Retro-transcribing viruses; Retroviridae;
            Orthoretrovirinae; Alpharetrovirus.
REFERENCE   1  (residues 1 to 526)
  AUTHORS   Petropoulos,C.J.
  TITLE     Appendix 2: Retroviral taxonomy, protein structure, sequences, and
            genetic maps
  JOURNAL   (in) Coffin,J.M. (Ed.);
            RETROVIRUSES: 757;
            Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York,
            NY, USA (1997)
REFERENCE   2  (residues 1 to 526)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (03-SEP-2004) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 526)
  AUTHORS   Chappey,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-NOV-1997) NIH, NLM, Rockville Pike, Bethesda, MD
            20894, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AAC82563.
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Rous sarcoma virus"
                     /db_xref="taxon:11886"
     Protein         1..526
                     /product="p60 src"
                     /name="p60-SRC phosphoprotein"
                     /calculated_mol_wt=58999
     mat_peptide     2..526
                     /product="pp60 SRC"
                     /protein_id="NP_955616.1"
                     /db_xref="GI:40796163"
                     /calculated_mol_wt=58999
     Region          85..139
                     /region_name="SH3"
                     /note="Src homology 3 domains; SH3 domains bind to
                     proline-rich ligands with moderate affinity and
                     selectivity, preferentially to PxxP motifs; they play a
                     role in the regulation of enzymes by intramolecular
                     interactions, changing the subcellular localization...;
                     cd00174"
                     /db_xref="CDD:29136"
     Site            order(90,92,99,118,133,136)
                     /site_type="other"
                     /note="proline-rich ligand binding site"
                     /db_xref="CDD:29136"
     Site            order(95..96,98..99,110..111,116..117)
                     /site_type="other"
                     /note="RTand n-Src loops"
                     /db_xref="CDD:29136"
     Region          147..245
                     /region_name="SH2"
                     /note="Src homology 2 domains; Signal transduction,
                     involved in recognition of phosphorylated tyrosine (pTyr).
                     SH2 domains typically bind pTyr-containing ligands via two
                     surface pockets, a pTyr and hydrophobic binding pocket,
                     allowing proteins with SH2...; cd00173"
                     /db_xref="CDD:29135"
     Site            order(155,175,201,203)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket"
                     /db_xref="CDD:29135"
     Site            order(202,230)
                     /site_type="other"
                     /note="hydrophobic binding pocket"
                     /db_xref="CDD:29135"
     Region          260..516
                     /region_name="PKc_like"
                     /note="Protein Kinases, catalytic domain; cl09925"
                     /db_xref="CDD:127277"
     Region          267..516
                     /region_name="Pkinase_Tyr"
                     /note="Protein tyrosine kinase; pfam07714"
                     /db_xref="CDD:116328"
     Site            order(273..277,281,293,295,338..341,344..345,386,390..391,
                     393,404,421..425,434,468)
                     /site_type="active"
                     /db_xref="CDD:88314"
     Site            order(273..274,276..277,281,293,295,338..341,344..345,
                     390..391,393,404)
                     /site_type="other"
                     /note="ATP binding site"
                     /db_xref="CDD:88314"
     Site            order(386,390,421..425,434,468)
                     /site_type="other"
                     /note="substrate binding site"
                     /db_xref="CDD:88314"
     Site            order(403..410,421..423)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:88314"
     CDS             1..526
                     /gene="src"
                     /locus_tag="RSVgp4"
                     /coded_by="NC_001407.1:7129..8709"
                     /db_xref="GeneID:1491925"
ORIGIN      
        1 mgsskskpkd psqrrhslep pdsthhggfp asqtpdetaa pdahrnpsrs fgtvatepkl
       61 fwgfntsdtv tspqragala ggvttfvaly dyeswtetdl sfkkgerlqi vnntegdwwl
      121 ahslttgqtg yipsnyvaps dsiqaeewyf gkitrreser lllnpenprg tflvrkseta
      181 kgayclsvsd fdnakgpnvk hykiyklysg gfyitsrtqf gslqqlvayy skhadglchr
      241 lanvcptskp qtqglakdaw eipreslrle aklgqgcfge vwmgtwndtt rvaiktlkpg
      301 tmspeaflqe aqvmkklrhe klvqlyavvs eepiyiviey mskgslldfl kgemgkylrl
      361 pqlvdmaaqi asgmayverm nyvhrdlraa nilvgenlvc kvadfglarl iedneytarq
      421 gakfpikwta peaalygrft iksdvwsfgi lltelttkgr vpypgmvnre vldqvergyr
      481 mpcppecpes lhdlmcqcwr kdpeerptfk ylqaqllpac vlevae
//