BIOGRAPHICAL SKETCH

 

Provide the following information for the key personnel in the order listed on Form page 2.

Photocopy this page or follow this format for each person.

 

NAME

POSITION TITLE

 

 

                      Alexander P. Lin

Graduate Student

 

 

EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

 

 

INSTITUTION AND LOCATION

 

DEGREE

(if applicable)

 

YEAR(s)

 

FIELD OF STUDY

California Institute of Technology, Pasadena, CA

BS

       2003

Biology

California Institute of Technology, Pasadena, CA

MS

 2006

Bioengineering

California Institute of Technology, Pasadena, CA

 Ph.D.

 Current

 Biochem. & Mol. Biophysics
           

                                                                                       

 

Work Experience

                        Senior Scientist/Director of MR Services                                             2003-2005

                        Rudi Schulte Research Institute, Santa Barbara, CA                                

 

                        Research Associate/Clinical Coordinator                                             1997-2003

                        Huntington Medical Research Institutes, Clinical MRS Lab.  Pasadena, CA

 

                        Research Technician                                                                           1994-1995

                        California Institute of Technology, Dept of Electrical Engineering.  Pasadena CA

 

                        Research Assistant                                                                               1993-1994

                        California Institute of Technology, Dept. of Molecular Biology.  Pasadena, CA

 

Professional Activities

                        Visiting Associate, University of Illiniois Chicago, Center for MR Research

                        Member, NIH/NINDS NeuroAIDS Grant Review Committee                     

Course coordinator and lecturer, Clinical MR Spectroscopy, Pasadena (1998-Current)

GE MR Masters Series Course Instructor (1999-Current)

ASRT accredited Course Instructor (sMRT: Spectroscopy for the MR Technologist)

Reviewer for Neuroimage, NMR in Biomedicine, and J Magnetic Resonance

Member of the ISMRM, ESMRB, SCMR, RSNA, and AAN.

 

Awards

American Heart Association Pre-doctoral Fellowship, 2006-Current

Gordon and Betty Moore Discovery Grant Award, 2006

Rudi Schulte Research Institute Fellowship, 2005-Current

Caltech Dean Scholarship, 2005-Current

1st place, Young Investigators Award, European Society of Magnetic Resonance in Medicine and Biology, 2003.

 

Publications (click on PMID for weblink)

1.      Lin AP, Ross BD, Harris K, Wong W.  Efficacy of Proton Magnetic Resonance Spectroscopy in Neurological Diagnosis and Neurotherapeutic Decision-Making.  NeuroRx.  2(2): 197-214 (2005).  PMID: 15897945

2.       Bhattacharya P, Harris K, Lin A, Mansson M, Norton V, Perman W, Weitekamp D, Ross BD.  Ultrafast Three Dimensional Free Precession Imaging.  MAGMA 2005 Oct;18(5):245-56.  PMID: 16320090

3.       England B, Lee A, Tran T, Faw H, Yang P, Lin A, Roth F, Ross BD.  Magnetic Resonance Criteria for Future Trials of Cardiac Resynchronization Therapy.  J Cardiac Magn Reson.  2005; 7(5):827-834. PMID: 16353444

4.       Ross BD, Lin A.  Introduction to Clinical Proton MR Spectroscopy.  Magnetic Resonance Update May 2005.

5.       Haseler LJ, Lin AP, Richardson RS.  Skeletal muscle oxidative metabolism in sedentary humans: 31P MRS assessment of O2 supply and demand limitations.  J Appl Physiol. 2004 Sep;97(3):1077-81. PMID: 15133010

6.     Lin AP, Shic F, Enriquez E, Ross BD.  Reduced glutamate neurotransmission in patients with Alzheimer’s disease – an in vivo 13C magnetic resonance spectroscopy.  MAGMA.  16:29-42 (2003) PMID: 12695884

7.       Ross BD, Lin AP, Harris K.  Clinical Experience with 13C MRS in vivo.  NMR in Biomed.  2003 Oct/Nov; 16(6): 358-369. PMID: 14679500

8.       Ross BD, Lin A.  Neurological Applications of Magnetic Resonance Spectroscopy.  Magnetic Resonance Update 2003.

9.       Lin A, Ross BD.  Virtual Biopsy Becomes Possible with Neurospectroscopy.  Diagnostic Imaging 2002; 24(9):44-48.

10.   Cecil KM, Lin A, Ross BD, Egelhoff JC.  Methylsulfonylmethane Observed by in vivo Proton Magnetic Resonance Spectroscopy in a Five Year Old Child with Developmental Disorder: Effects of Dietary Supplementation.  J Comput Assist Tomogr. 2002 Sep-Oct;26(5):818-20.  PMID: 12439321

11.   Lin AP, Ross BD.  Short-Echo Time Proton MR Spectroscopy in the Presence of Gadolinium JCAT. September/October 2001;25(5):705-713. PMID: 11584229

12.   Lin A, C-H Nguy, F. Shic, BD Ross.  Accumulation of Methylsulfonylmethane (MSM) in the Human Brain: Identification by Magnetic Resonance Spectroscopy. Toxicology Letters, 2001;123:169-177.  PMID: 11641045

13.   Pandit S, Lin A, Gahbauer H, Libertin C R, Erdogan B.  MR spectroscopy in Neurocysticercosis.  J. Comp. Assist. Tomogr. 2001; 26(6):950-952.  PMID: 11711809

14.   Ross BD, Hoang T, Bluml S, Dubowitz D, Kopyov O, Jacques D, Lin A, Seymour KJ and Tan J.  In vivo magnetic resonance spectroscopy of human fetal tissue transplants.  NMR in Biomedicine 12:221-236  (1999). PMID: 10421914

15.   Lin A, Bluml S, Mamelak A. Efficacy of Proton Magnetic Resonance Spectroscopy In Clinical Decision Making for Patients with Suspected Malignant Brain Tumors.  Journal of Neuro-Oncology.  45(1): 69-81, 1999.  PMID: 10728912

 

Book Chapters

16.   Lin AP.  Chapter 1: Acquiring Magnetic Resonance Spectroscopy in Clinical Practice.  Handbook of Modern Magnetic Resonance, Kluwer Academic Publishers, London. Eds. C. Mountford and G.A. Webb. (2006)

17.   Ross BD, Colletti P, Lin A.  Chapter 30: MR Spectroscopy of the Brain.  Clinical Magnetic Resonance Imaging, Third Edition, W.B. Saunders Co, Philadelpha PA.  Eds. Edelman R, Hesselink JR, Zlatkin MB. (2006)

18.   Ross BD, Lin A, Enriquez C. Chapter 41 MRS spectroscopy of hypoxic brain injury.  Physiological MR in Clinical Neuroscience. Cambridge Univ Press, Cambridge UK.  Eds. Gillard, Waldman, and Barker. (2005)

19.   Ross BD, Bluml S, Seymour KJ, Tan J, Hwang JH, Lin A.  Systemically Induced Encephalopathies: Newer Clinical Applications of MRS.  Encyclopedia of Nuclear Magnetic Resonance, J Wiley & Sons, NY Grant DM and Harris RK (1999).

 

Selected Conference Abstracts

20.   Lin A, Bluml S, Caton W, Dumas C, Mamelak A, Rand R, Wiseman C, Ross BD.  Added value of single-voxel, quantitative, short echo-time 1H MRS of brain tumor in patients with indeterminate MRI.  ISMRM Workshop on Magnetic Resonance in Experimental and Clinical Cancer Research.  Nov. 13-15, 1998 p. 74.

21.   Lin A, Bluml S, Seymour KJ, Tan J, Ross BD.  Quantitative proton decoupled 31P MRS of normal brain and treated human brain tumors. ISMRM Workshop on Magnetic Resonance in Experimental and Clinical Cancer Research.  Nov. 13-15, 1998  p. 77.

22.   Lin A, Bluml S, Mamelak A, Ross BD.  Clinical efficacy and added value of quantitative MR spectroscopy  compared with MRI in patients with suspected brain tumors. 67th Annual Meeting of the American Association of Neurological Surgeons.  April 24-29, 1999 p 306.

23.   Lin A, Moreno A, Norfray J, Ross BD.  No impact of Gd-DTPA on quantitative MRS of human brain tumors.   Radiology. 1999. 213(P): 355 85th Annual Meeting of Radiological Society of North America, Chicago (1999)

24.   Lin A, Grossman T, Shriner K, Friedman M, Nguy CH, Ling JF, Bluml S, Ross BD.  Double Blind Trial of 1H MRS Monitoring Antiretroviral  Therapy. Proc of 8th Intl Magn Reson Med (2000).

25.   Lin A, Shic F, Ross BD, Panagiotacopulos N, et .al.  Wavelet Analysis of Brain Tumors in Clinical MRS., 4th World Multiconference on Circuits, Systems, Communications and Computers (CSCC 2000), Vouliagmeni-Athens, Greece , July 10-15, 2000 (paper submitted in this Conference).

26.   Lin A, Shic F, Ross BD.  Differentiating Diffuse Brainstem Neoplasms using Proton Magnetic Resonance Spectroscopy. Proc of 9th Intl Magn Reson Med 2001..

27.   Lin A, Brooks, M, Ross BD.  Cost-effectiveness of MRS in the Management of Recurrent Brain Tumors. Proc of 9th Intl Magn Reson Med 2001.

28.   Lin A, Koyov O, Ross BD, Philipott L, Jacques D.  Monitoring intrahippocampal neurotransplant for Alzheimer's disease.  Amer. Acad. Neurol. 2001.

29.   Lin AP, Tabor J, Ingeholm ML, Eichler F and BD Ross.  S.O.S.: Spectroscopy over-reading service – an online WWW/PACS based teleradiology system for MR spectroscopy readings utilizing internet-2 technology. Radiology 2001; 221(P):730.

30.   Lin A, Huong CN, Shic F, Ross BD.  Identification of Dietary Supplement Methylsulfonyl Methane (MSM) in the Brain by Multinuclear Magnetic Resonance Spectroscopy. Radiology. 2001;221(P):483

31.   Bluml S, Shic F, Lai L, Yahya K, Lin A, Ross BD.  Glutamate-glutamine cycling in epileptic patients on ketogenic diets.  Proceedings, 10th International Society for Magnetic Resonance in Medicine.  2002.

32.   Shic F, Ross BD, Yahya K, Lin A, Lai L, Bluml S.  A protocol for the synchronous assay of in vivo glial and neuronal metabolic rates in man.  Proceedings, 10th International Society for Magnetic Resonance in Medicine.  2002.

33.   Lin A, Shic F, Zapata M, Pang W, Ross BD.  Magnetic Resonance Spectroscopy Diagnosis of Alzheimer Disease: Verification at Autopsy.  Neurobiology of Aging.  2002; 23(1S): S465.

34.   Lin A, Shic F, Enriquez C, Ross BD.  Evidence of reduced glutamate neurotransmission in patients with Alzheimer’s disease – An in vivo 13C MRS study.  MAGMA. 2002; 15(1S): 69-70.  1st place Winner of the Young Investigator Award.

35.   Lin A, Enriquez C, Ross BD.  1H Magnetic Resonance Spectroscopy Detection of Chromosomal Defects in Alzheimer’s Disease and Down Syndrome.  Proceedings, 11th International Society for Magnetic Resonance in Medicine.  2003.

36.   Lin AP, Denham J, Smillie J, Wijesinge A, Enriquez C, Harris K, Shriner K, Ross BD.  Abnormal brain 1H MRS may be predictive of Lipodystrophy in HIV positive patients. ISMRM Workshop on Dynamic Spectroscopy and Measurements of Physiology, Metabolism, and Function 2003. 

37.   Lin AP, Shic F, Enriquez CM, Geschwind M, and Ross BD. Abnormal Glutamate Neurotransmission Observed by 13C MRS in Patients with Adult Polyglucosan Storage Disease. ISMRM Workshop on Dynamic Spectroscopy and Measurements of Physiology, Metabolism, and Function 2003.

38.   Lin A, Lin D, Lin C, Ross BD.  Semi-automated reporting software for clinical proton magnetic resonance spectroscopy exams.  Radiological Society of North America, 2003.

39.   England B, Enriquez C, Lee A, Lin A, Colletti P, Roth F, Rashtian M, Myers M, Ross BD.  Efficacy of MR Indicators for Cardiac Resynchronization Therapy.  Society for Cardiovascular Magnetic Resonance. 2004.

40.   Colletti PM, Berry K, Lin A, Singh M, Ross BD.  Principles of Diffusion Tensor Imaging.  American Roentgen Ray Society.  2004.  Certificate of Merit Award.

41.   Lin AP, Berry KE, Cooper K, Ross BD.  Diffusion Tensor Imaging and MR Spectroscopy in Patients with Hydrocephalus.  International Society of Magnetic Resonance in Medicine 2004  meeting.

42.   Lee A, Lin AP, Enriquez C, England B, Colletti P, Rashtian M, Myers M, Ross B.  Efficacy of MASS and HARP for Cardiac Resynchronization Therapy (CRT).  International Society of Magnetic Resonance in Medicine 2004  meeting.

43.   Lin AP, Berry K, Ross BD.  Virtual Dissections: Non-Invasive Characterization Of Fiber Tracts in Normal Pressure Hydrocephalus with Diffusion Tensor Imaging and MR Spectroscopy. Radiological Society of North America 2004 meeting.

44.   Harris K, Lin AP, Bhattacharya, Ross BD. Apparent glutamate neurotransmitter rate is reduced in shizophrenic humans: A 1-13C glucose MRS study.  European Society of Magnetic Resonance in Medicine and Biology 2004 meeting.

45.   Bhattacharya P, Weitekamp D, Harris K, Lin AP, Ross BD. Towards the Development of Smart Contrast Agents Employing PASADENA.  European Society of Magnetic Resonance in Medicine and Biology 2004 meeting

46.   Tran T, Lee A, Lin A, Ross BD,.  A Quantitative Method for Determining Asynchrony and Asymmetry in Wall Motion by Cardiovascular Magnetic Resonance Imaging and MASS Analysis.  Society of Cardiovascular Magnetic Resonance 2005.  2nd place Technology Award.

47.   Lin A, Kopyov O, Ross BD.  Feasibility, Safety, and Clinical Utility of Proton Magnetic Resonance Spectroscopy in the Presence of Deep Brain Stimulators for Parkinson’s Disease.  International Society of Magnetic Resonance in Medicine 2005 meeting.

48.   Lin A, Harris K, Shic F, Ross BD.  Apparent Rate of NAA Synthesis is Increased in Alzheimer’s Disease.  International Society of Magnetic Resonance in Medicine 2005 meeting.

49.   Bhattacharya P, Weitekamp D, Harris K, Lin A, Ross BD.  Development of Contrast Agents Employing PASADENA.  International Society of Magnetic Resonance in Medicine 2004 meeting.

50.   Harris K, Lin AP, Perman WH, Bhattacharya P, Weitekamp D, Ross BD.  3-D Ehanced Fast Gradient Echo 13C Carbon Imaging in a 1.5T Clinical Scanner.  International Society of Magnetic Resonance in Medicine 2004 meeting.

51.   Bhattacharya P, Norton V, Mansson M, Harris K, Lin A, Ross BD, Weitekamp DP.  Ultra-fast Real Time Imaging Employing PASADENA-PHIP.  Gordon Research Conference in Magnetic Resonance.  June 5-10, 2005.

52.   Lin A, Kopyov O, Ross BD.  Feasibility, Safety, and Clinical Utility of Proton Magnetic Resonance Spectroscopy in the Presence of Deep Brain Stimulators for Parkinson’s Disease.  International Society of Magnetic Resonance in Medicine 2005 meeting.

53.   Lin A, Harris K, Shic F, Ross BD.  Apparent Rate of NAA Synthesis is Increased in Alzheimer’s Disease.  International Society of Magnetic Resonance in Medicine 2005 meeting.

54.   Bhattacharya P, Weitekamp D, Harris K, Lin A, Ross BD.  Development of Contrast Agents Employing PASADENA.  International Society of Magnetic Resonance in Medicine 2005 meeting.

55.   Harris K, Lin AP, Perman WH, Bhattacharya P, Weitekamp D, Ross BD.  3-D Ehanced Fast Gradient Echo 13C Cabron Imaging in a 1.5T Clinical Scanner.  International Society of Magnetic Resonance in Medicine 2005 meeting.

56.   Lin AP, Kohler SJ, Harris K, Mansson M, Bhattacharya P, Ross BD.  Metabolic Imaging of Hyperpolarized 13C Substrates using Echo Planar Chemical Shift Imaging.  European Society of Magnetic Resonance in Medicine and Biology 2005.

57.   Perman WH, Lin AP, Harris K, Bhattacharya P, Kohler SJ, Ross BD.  Comparison of Pulse Sequences for Imaging of Hyperpolarized 13C Reagents.  European Society of Magnetic Resonance in Medicine and Biology 2005.

58.   Wen H, Lin AP, Vignaud A, Bennett E.  Regional Strain Mapping of the Carotid Arterial Wall in Humans using DENSE.  European Society of Magnetic Resonance in Medicine and Biology 2005.

59.   Lin AP, Tyszka JM, Bennett E, Fraser S, Wen H. Preliminary Validation of Circumferential Strain Measurements using DENSE at 1.5T and 3T. in Society for Cardiovascular Magnetic Resonance Ninth Annual Scientific Sessions. 2006. Miami, FL.

60.   Lin AP, Tran T, Bhattacharya P, Harris K, Ross BD.  Fast Chemical Shift Imaging of Hyperpolarized 13C Substrates.  International Society of Magnetic Resonance in Medicine 2006 meeting.

61.   Lin AP, Perman WH, Leupold J, Bhattacharya P, Harris K, Henning J, Ross BD.  13C Pasadena Imaging In Vivo.  International Society of Magnetic Resonance in Medicine 2006 meeting.

62.   Ross BD, Lin AP, Bhattacharya P, Harris K, Kanamori K, Freundlich A, Tran T.  Limits of detection of hyperpolarized 13C in vitro and in vivo.  International Society of Magnetic Resonance in Medicine 2006 meeting.

63.   Bhattacharya P, Norton VA, Lin AP, Harris K, Leupold J, Perman W, Hennig J, Ross BD, Weitekamp D.  Simultaneous Hyperpolarization of Multiple 13C Molecules In Vitro & In Vivo: Towards Rapid Metabolite Mapping By MRS & MRI.  International Society of Magnetic Resonance in Medicine 2006 meeting.

64. Perman WH, Leupold J, Bhattacharya P, Lin A, Harris K, Hennig J, Ross BD.  Fast 4D Metabolite Mapping of Hyperpolarized 13C Compounds using Multiple Echo 3D FIESTA.  International Society of Magnetic Resonance in Medicine 2006 meeting.